Historical and current perspectives on blood endothelial cell heterogeneity in the brain

Single-cell dissection of the human brain vasculature

(2022) Francisco J. Garcia et al.   NATURE

A paradigm shift in structural biology

(2022) Sriram Subramaniam et al.   NATURE METHODS

A single-cell atlas of the normal and malformed human brain vasculature

(2022) Ethan A. Winkler et al.   SCIENCE

Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders

(2022) Maud Martin et al.   SCIENCE

Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier

(2022) Swathi Ayloo et al.   NEURON

Endothelial Unc5B controls blood-brain barrier integrity

(2022) Kevin Boyé et al.   Nature Communications

To be or not to be: endothelial cell plasticity in development, repair, and disease

(2021) Leah J. Greenspan et al.   ANGIOGENESIS

Blood–Brain Barrier Dynamics to Maintain Brain Homeostasis

(2021) Marta Segarra et al.   TRENDS IN NEUROSCIENCES

A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

(2021) Shirley L. Zhang et al.   Nature Communications

A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

(2021) François Kroll et al.   eLife

Endothelial cell type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain

(2021) Sweta Parab et al.   eLife

Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease

(2021) Afshin Rahbarghazi et al.   Journal of Inflammation-London

Developmental regulation of barrier‐ and non‐barrier blood vessels in the CNS

(2021) A. Ben‐Zvi et al.   JOURNAL OF INTERNAL MEDICINE

Strategies for delivering therapeutics across the blood–brain barrier

(2021) Georg C. Terstappen et al.   NATURE REVIEWS DRUG DISCOVERY

Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas

(2021) Francesco Girolamo et al.   Fluids and Barriers of the CNS

Endothelial ontogeny and the establishment of vascular heterogeneity

(2021) Oliver A. Stone et al.   BIOESSAYS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Revisiting the neurovascular unit

(2021) Samantha Schaeffer et al.   NATURE NEUROSCIENCE

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

(2021) M. Grunewald et al.   SCIENCE

Integrated molecular analysis identifies a conserved pericyte gene signature in zebrafish

(2021) Yu-Huan Shih et al.   DEVELOPMENT

Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development

(2021) Koji Ando et al.   DEVELOPMENTAL BIOLOGY

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C

(2021) Mikko T. Huuskonen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-related immune alterations and cerebrovascular inflammation

(2021) Carson E. Finger et al.   MOLECULAR PSYCHIATRY

Emerging roles for CNS fibroblasts in health, injury and disease

(2021) Cayce E. Dorrier et al.   NATURE REVIEWS NEUROSCIENCE

Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

(2021) Benjamin D Gastfriend et al.   eLife

Highly Efficient Synthetic CRISPR RNA/Cas9-Based Mutagenesis for Rapid Cardiovascular Phenotypic Screening in F0 Zebrafish

(2021) Rachael E. Quick et al.   Frontiers in Cell and Developmental Biology

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

(2020) Mark F Sabbagh et al.   eLife

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

(2020) Ankit Jambusaria et al.   eLife

Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain

(2020) Sara I. Graves et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

(2020) Koen Veys et al.   CIRCULATION RESEARCH

The blood–brain barrier in health and disease: Important unanswered questions

(2020) Caterina P. Profaci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transferrin receptor 1 targeted optical imaging for identifying glioma margin in mouse models

(2020) Xiang-Rong Ni et al.   JOURNAL OF NEURO-ONCOLOGY

MCH Neurons Regulate Permeability of the Median Eminence Barrier

(2020) Hong Jiang et al.   NEURON

Recent advances in human iPSC-derived models of the blood–brain barrier

(2020) Michael J. Workman et al.   Fluids and Barriers of the CNS

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function

(2020) John DeSisto et al.   DEVELOPMENTAL CELL

Physiological blood–brain transport is impaired with age by a shift in transcytosis

(2020) Andrew C. Yang et al.   NATURE

Neuronal regulation of the blood–brain barrier and neurovascular coupling

(2020) Luke Kaplan et al.   NATURE REVIEWS NEUROSCIENCE

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

(2020) Kevin R. Parker et al.   CELL

Single-Cell RNA-seq Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells

(2020) David T. Paik et al.   CIRCULATION

No Evidence for Erythro-Myeloid Progenitor-Derived Vascular Endothelial Cells in Multiple Organs

(2020) Teng Feng et al.   CIRCULATION RESEARCH

Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain

(2020) Benjamin P. Heithoff et al.   GLIA

Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes

(2020) Robert S. Pulido et al.   NEURON

Aging of the Vascular System and Neural Diseases

(2020) Chisato Watanabe et al.   Frontiers in Aging Neuroscience

Light-sheet fluorescence imaging charts the gastrula origin of vascular endothelial cells in early zebrafish embryos

(2020) Meijun Pang et al.   Cell Discovery

Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance

(2020) Sylvaine Guérit et al.   PROGRESS IN NEUROBIOLOGY

Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood–brain barrier

(2020) Manuel Zeitelhofer et al.   Scientific Reports

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

(2019) Divna Lazic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution

(2019) Samuel G. Rodriques et al.   SCIENCE

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Development of the brain vasculature and the blood-brain barrier in zebrafish

(2019) Claudia Quiñonez-Silvero et al.   DEVELOPMENTAL BIOLOGY

Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium

(2019) Oliver A. Stone et al.   DEVELOPMENTAL CELL

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

(2019) Yanshu Wang et al.   eLife

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

(2019) Fabienne Benz et al.   eLife

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Targeting the transferrin receptor for brain drug delivery

(2019) Kasper Bendix Johnsen et al.   PROGRESS IN NEUROBIOLOGY

Regulation of the Blood–Brain Barrier by Circadian Rhythms and Sleep

(2019) Vishnu Anand Cuddapah et al.   TRENDS IN NEUROSCIENCES

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

(2019) Lachlan S. Brown et al.   Frontiers in Cellular Neuroscience

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes

(2019) Rodrigo Diéguez-Hurtado et al.   Nature Communications

Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression

(2019) Agnieszka Martowicz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transcytosis at the blood–brain barrier

(2019) Swathi Ayloo et al.   CURRENT OPINION IN NEUROBIOLOGY

High-definition spatial transcriptomics for in situ tissue profiling

(2019) Sanja Vickovic et al.   NATURE METHODS

Suppression of transcytosis regulates zebrafish blood-brain barrier function

(2019) Natasha M O'Brown et al.   eLife

The fenestrae-associated protein Plvap regulates the rate of blood-borne protein passage into the hypophysis

(2019) Ludmila Gordon et al.   DEVELOPMENT

Emerging links between cerebrovascular and neurodegenerative diseases—a special role for pericytes

(2019) Urban Lendahl et al.   EMBO REPORTS

Probabilistic cell typing enables fine mapping of closely related cell types in situ

(2019) Xiaoyan Qian et al.   NATURE METHODS

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

(2019) Vladimir V. Senatorov et al.   Science Translational Medicine

Activated protein C, protease activated receptor 1, and neuroprotection

(2018) John H. Griffin et al.   BLOOD

A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux

(2018) Shirley L. Zhang et al.   CELL

Recent insights into vascular development from studies in zebrafish

(2018) Ryota L. Matsuoka et al.   CURRENT OPINION IN HEMATOLOGY

Bridging barriers: a comparative look at the blood–brain barrier across organisms

(2018) Natasha M. O'Brown et al.   GENES & DEVELOPMENT

Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain

(2018) Norman R. Saunders et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

A molecular mechanism for Wnt ligand-specific signaling

(2018) Marie Eubelen et al.   SCIENCE

A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5

(2018) Lisanne Martine van Leeuwen et al.   Biology Open

The physiology of endocrine systems with ageing

(2018) Annewieke W van den Beld et al.   Lancet Diabetes & Endocrinology

Targeting pericytes for therapeutic approaches to neurological disorders

(2018) Jinping Cheng et al.   ACTA NEUROPATHOLOGICA

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Erythro-myeloid progenitors contribute endothelial cells to blood vessels

(2018) Alice Plein et al.   NATURE

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system

(2018) Marta Segarra et al.   SCIENCE

Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain

(2018) Stéphanie Chasseigneaux et al.   Scientific Reports

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

(2018) Mark F Sabbagh et al.   eLife

Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces

(2018) Savani Anbalagan et al.   DEVELOPMENTAL CELL

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

(2018) Sonja Bergmann et al.   Nature Protocols

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood–brain barrier and blood–retina barrier development and maintenance

(2018) Yanshu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoic Acid Regulates Endothelial β-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature

(2018) Stephanie Bonney et al.   Frontiers in Cellular Neuroscience

Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

(2018) Kathleen Hübner et al.   Nature Communications

Endocytosis at the Drosophila blood–brain barrier as a function for sleep

(2018) Gregory Artiushin et al.   eLife

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

(2017) Roger I Grant et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Gpr124 is essential for blood–brain barrier integrity in central nervous system disease

(2017) Junlei Chang et al.   NATURE MEDICINE

Vascular heterogeneity and specialization in development and disease

(2017) Michael Potente et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

(2017) Chris Cho et al.   NEURON

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

CNS-resident progenitors direct the vascularization of neighboring tissues

(2017) Ryota L. Matsuoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD146 coordinates brain endothelial cell–pericyte communication for blood–brain barrier development

(2017) Jianan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms regulating angiogenesis underlie seasonal control of pituitary function

(2017) Jennifer Castle-Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Brain Pericytes As Mediators of Neuroinflammation

(2017) Justin Rustenhoven et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein

(2017) Maoxue Tang et al.   Nature Communications

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

The molecular basis of endothelial cell plasticity

(2017) Elisabetta Dejana et al.   Nature Communications

Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature

(2017) Tomoko Yamazaki et al.   Cell Reports

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control

(2017) Roberta Haddad-Tóvolli et al.   Frontiers in Neuroscience

A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS

(2017) Seiji Yamamoto et al.   Scientific Reports

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

(2016) Justin Rustenhoven et al.   Journal of Neuroinflammation

Diverse Functions of Retinoic Acid in Brain Vascular Development

(2016) S. Bonney et al.   JOURNAL OF NEUROSCIENCE

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

(2016) Sven Reischauer et al.   NATURE

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Pharmacological targeting of the PDGF-CC signaling pathway for blood–brain barrier restoration in neurological disorders

(2016) Sebastian A. Lewandowski et al.   PHARMACOLOGY & THERAPEUTICS

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

(2016) Yu Yamazaki et al.   STROKE

Plasmalemma vesicle-associated protein: A crucial component of vascular homeostasis

(2016) Ling Guo et al.   Experimental and Therapeutic Medicine

Radial glia regulate vascular patterning around the developing spinal cord

(2016) Ryota L Matsuoka et al.   eLife

Netrin 1 regulates blood–brain barrier function and neuroinflammation

(2015) Cornelia Podjaski et al.   BRAIN

Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain

(2015) Shoko Morita et al.   CELL AND TISSUE RESEARCH

Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System HomeostasisCLINICAL PERSPECTIVE

(2015) Khiem A. Tran et al.   CIRCULATION

Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas

(2015) Suraj Dixit et al.   MOLECULAR PHARMACEUTICS

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Wiring the Vascular Network with Neural Cues: A CNS Perspective

(2015) Thomas Wälchli et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Chamber identity programs drive early functional partitioning of the heart

(2015) Christian Mosimann et al.   Nature Communications

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS

(2015) Bettina Schreiner et al.   Cell Reports

Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

(2015) Benoit Vanhollebeke et al.   eLife

New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains

(2015) Seiji Miyata   Frontiers in Neuroscience

Gpr124 Controls CNS Angiogenesis and Blood-Brain Barrier Integrity by Promoting Ligand-Specific Canonical Wnt Signaling

(2014) Yulian Zhou et al.   DEVELOPMENTAL CELL

Canonical WNT signaling components in vascular development and barrier formation

(2014) Yulian Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

VEGF-dependent and PDGF-dependent dynamic neurovascular reconstruction in the neurohypophysis of adult mice

(2014) Eriko Furube et al.   JOURNAL OF ENDOCRINOLOGY

Sleep Restriction Impairs Blood-Brain Barrier Function

(2014) J. He et al.   JOURNAL OF NEUROSCIENCE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1

(2014) Phong Dang Nguyen et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transferrin Receptor 2 Is Frequently and Highly Expressed in Glioblastomas

(2014) Alessia Calzolari et al.   Translational Oncology

The Drosophila blood-brain barrier: development and function of a glial endothelium

(2014) Stefanie Limmer et al.   Frontiers in Neuroscience

Accessibility of low-molecular-mass molecules to the median eminence and arcuate hypothalamic nucleus of adult mouse

(2013) Shoko Morita et al.   CELL BIOCHEMISTRY AND FUNCTION

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

(2013) Fanny Langlet et al.   Cell Metabolism

Neurovascular development and links to disease

(2013) Christiana Ruhrberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Notch3 establishes brain vascular integrity by regulating pericyte number

(2013) Y. Wang et al.   DEVELOPMENT

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

Retinoic Acid Induces Blood-Brain Barrier Development

(2013) M. R. Mizee et al.   JOURNAL OF NEUROSCIENCE

Transporters of the blood–brain and blood–CSF interfaces in development and in the adult

(2013) Norman R. Saunders et al.   MOLECULAR ASPECTS OF MEDICINE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-Brain Barrier Integrity and by Modulating the Peripheral Immune Response

(2013) Milena Z. Adzemovic et al.   PLoS One

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Impaired blood–brain/spinal cord barrier in ALS patients

(2012) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

Different vascular permeability between the sensory and secretory circumventricular organs of adult mouse brain

(2012) Shoko Morita et al.   CELL AND TISSUE RESEARCH

The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition

(2012) Radu V. Stan et al.   DEVELOPMENTAL CELL

VEGF-dependent continuous angiogenesis in the median eminence of adult mice

(2012) S. Morita et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Claudin-5 expression in the vasculature of the developing chick embryo

(2012) Michelle M. Collins et al.   GENE EXPRESSION PATTERNS

Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice

(2012) Leonie Herrnberger et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage

(2011) Qingyi Ma et al.   ANNALS OF NEUROLOGY

The Hypothalamic Neuropeptide Oxytocin Is Required for Formation of the Neurovascular Interface of the Pituitary

(2011) Amos Gutnick et al.   DEVELOPMENTAL CELL

Sox10-iCreERT2: A mouse line to inducibly trace the neural crest and oligodendrocyte lineage

(2011) Christiane Simon et al.   GENESIS

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Cranial vasculature in zebrafish forms by angioblast cluster-derived angiogenesis

(2010) Kira Proulx et al.   DEVELOPMENTAL BIOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

(2010) Takeshi Nishijima et al.   NEURON

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Review: Cerebral microvascular pathology in ageing and neurodegeneration

(2010) W. R. Brown et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

(2009) Harald J. Junge et al.   CELL

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

(2009) Xin Ye et al.   CELL

Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for  -catenin

(2009) D. A. Hutcheson et al.   GENES & DEVELOPMENT

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmalemmal Vesicle Associated Protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models

(2008) Eveline H Shue et al.   BMC NEUROSCIENCE

Developmental origin of smooth muscle cells in the descending aorta in mice

(2008) P. Wasteson et al.   DEVELOPMENT

All vertebrates started out with a glial blood-brain barrier 4-500 million years ago

(2008) Magnus Bundgaard et al.   GLIA

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma

(2008) Arindel S.R. Maharaj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Organization and Function of the Blood Brain Barrier in Drosophila

(2008) T. Stork et al.   JOURNAL OF NEUROSCIENCE

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE

Functional and developmental analysis of the blood–brain barrier in zebrafish

(2007) Jae-Yeon Jeong et al.   BRAIN RESEARCH BULLETIN