Physiological blood–brain transport is impaired with age by a shift in transcytosis

The blood–brain barrier in health and disease: Important unanswered questions

(2020) Caterina P. Profaci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

(2020) Michelle B. Chen et al.   Cell Reports

Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response

(2019) Yvette Zarb et al.   BRAIN

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

(2019) Hanadie Yousef et al.   NATURE MEDICINE

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

11C-DPA-713 versus18F-GE-180: A preclinical comparison of TSPO-PET tracers to visualize acute and chronic neuroinflammation in a mouse model of ischemic stroke

(2018) Aisling Chaney et al.   JOURNAL OF NUCLEAR MEDICINE

Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain

(2018) Norman R. Saunders et al.   JOURNAL OF PHYSIOLOGY-LONDON

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics

(2018) Andrew C. Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

(2018) Mark F Sabbagh et al.   eLife

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma

(2018) Kévin Contrepois et al.   Scientific Reports

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipidomic characterization and localization of phospholipids in the human lung

(2017) Karin A. Zemski Berry et al.   JOURNAL OF LIPID RESEARCH

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore

(2016) Xiao-Dong Zhang et al.   ADVANCED MATERIALS

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

(2016) Y. Joy Yu Zuchero et al.   NEURON

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

GeneAnalytics: An Integrative Gene Set Analysis Tool for Next Generation Sequencing, RNAseq and Microarray Data

(2016) Shani Ben-Ari Fuchs et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Incorporation of non-canonical amino acids into the developing murine proteome

(2016) Sarah Calve et al.   Scientific Reports

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Internalization of targeted quantum dots by brain capillary endothelial cells in vivo

(2015) Sarah Paris-Robidas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping

(2015) Jennifer B Treweek et al.   Nature Protocols

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Development and Validation of an Immuno-PET Tracer as a Companion Diagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6 Epitope

(2015) Ohad Ilovich et al.   RADIOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Transcriptome analyses of adult mouse brain reveal enrichment of lncRNAs in specific brain regions and neuronal populations

(2015) Beena M. Kadakkuzha et al.   Frontiers in Cellular Neuroscience

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Non-invasive in vivo measurement of cardiac output in C57BL/6 mice using high frequency transthoracic ultrasound: evaluation of gender and body weight effects

(2014) Elisabet Domínguez et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Ultrasensitive proteome analysis using paramagnetic bead technology

(2014) C. S. Hughes et al.   Molecular Systems Biology

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

(2014) Norman R. Saunders et al.   Frontiers in Neuroscience

Transporters of the blood–brain and blood–CSF interfaces in development and in the adult

(2013) Norman R. Saunders et al.   MOLECULAR ASPECTS OF MEDICINE

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

(2013) Annika Keller et al.   NATURE GENETICS

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Quantitative assessment of single-cell RNA-sequencing methods

(2013) Angela R Wu et al.   NATURE METHODS

Developing Therapeutic Antibodies for Neurodegenerative Disease

(2013) Y. Joy Yu et al.   Neurotherapeutics

Binding, Transcytosis and Biodistribution of Anti-PECAM-1 Iron Oxide Nanoparticles for Brain-Targeted Delivery

(2013) Mo Dan et al.   PLoS One

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

(2013) Itender Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Positron Emission Tomography (PET) Radioligand for Imaging σ-1 Receptors in Living Subjects

(2012) Michelle L. James et al.   JOURNAL OF MEDICINAL CHEMISTRY

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Validation of Noninvasive Measurements of Cardiac Output in Mice Using Echocardiography

(2011) François Tournoux et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Alkaline Phosphatase Is Increased in both Brain and Plasma in Alzheimer’s Disease

(2011) Emma R.L.C. Vardy et al.   Neurodegenerative Diseases

Comparison of bifunctional chelates for 64Cu antibody imaging

(2010) Cara L. Ferreira et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Local clustering of transferrin receptors promotes clathrin-coated pit initiation

(2010) Allen P. Liu et al.   JOURNAL OF CELL BIOLOGY

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells

(2010) Joseph D. Dougherty et al.   NUCLEIC ACIDS RESEARCH

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Discovery and Validation of a Series of Aryl Sulfonamides as Selective Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP)

(2009) Russell Dahl et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY