Revisiting the neurovascular unit

CNS fibroblasts form a fibrotic scar in response to immune cell infiltration

(2021) Cayce E. Dorrier et al.   NATURE NEUROSCIENCE

Brain capillary pericytes exert a substantial but slow influence on blood flow

(2021) David A. Hartmann et al.   NATURE NEUROSCIENCE

Brain endothelial cell TRPA1 channels initiate neurovascular coupling

(2021) Pratish Thakore et al.   eLife

REGULATION OF CEREBRAL BLOOD FLOW IN HUMANS: PHYSIOLOGY AND CLINICAL IMPLICATIONS OF AUTOREGULATION

(2021) Jurgen A.H.R. Claassen et al.   PHYSIOLOGICAL REVIEWS

Continuous cerebrovascular reactivity monitoring in moderate/severe traumatic brain injury: a narrative review of advances in neurocritical care

(2020) Frederick A. Zeiler et al.   BRITISH JOURNAL OF ANAESTHESIA

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

The association between resting‐state functional magnetic resonance imaging and aortic pulse‐wave velocity in healthy adults

(2020) Ahmad Hussein et al.   HUMAN BRAIN MAPPING

Association of Blood Pressure With Outcomes in Acute Stroke Thrombectomy

(2020) Konark Malhotra et al.   HYPERTENSION

Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFRβ+/− mice

(2020) Ashley N Watson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alzheimer’s Disease and Vascular Aging

(2020) Marta Cortes-Canteli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Caveolae in CNS arterioles mediate neurovascular coupling

(2020) Brian W. Chow et al.   NATURE

Perivascular spaces in the brain: anatomy, physiology and pathology

(2020) Joanna M. Wardlaw et al.   Nature Reviews Neurology

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Precapillary sphincters maintain perfusion in the cerebral cortex

(2020) Søren Grubb et al.   Nature Communications

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

(2020) Kalil Alves de Lima et al.   Annual Review of Immunology

Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development

(2020) Sebastian G. Utz et al.   CELL

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

(2020) Aliza P. Wingo et al.   NATURE NEUROSCIENCE

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

(2020) Michelle B. Chen et al.   Cell Reports

Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia

(2020) Maiko T. Uemura et al.   Frontiers in Aging Neuroscience

In vitro modeling of the neurovascular unit: advances in the field

(2020) Aditya Bhalerao et al.   Fluids and Barriers of the CNS

Nitric oxide is fundamental to neurovascular coupling in humans

(2020) Ryan L. Hoiland et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice

(2020) Julie Ouellette et al.   NATURE NEUROSCIENCE

Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration

(2020) Laibaik Park et al.   NATURE NEUROSCIENCE

Neuronal regulation of the blood–brain barrier and neurovascular coupling

(2020) Luke Kaplan et al.   NATURE REVIEWS NEUROSCIENCE

Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds

(2020) Patrick J. Drew et al.   NEURON

Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension

(2020) Monica M. Santisteban et al.   HYPERTENSION

Blood flow, capillary transit times, and tissue oxygenation. The centennial of capillary recruitment

(2020) Leif Østergaard   JOURNAL OF APPLIED PHYSIOLOGY

REM sleep behavior disorder (RBD)

(2020) Michele T. Hu   NEUROBIOLOGY OF DISEASE

Contractile pericytes determine the direction of blood flow at capillary junctions

(2020) Albert L. Gonzales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalent and sex-biased breathing patterns modify functional connectivity MRI in young adults

(2020) Charles J. Lynch et al.   Nature Communications

nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice

(2020) Christina T Echagarruga et al.   eLife

Orthostatic Hypotension Is Associated With Cognitive Decline in Parkinson Disease

(2020) Katherine Longardner et al.   Frontiers in Neurology

Functional hyperemia drives fluid exchange in the paravascular space

(2020) Ravi Teja Kedarasetti et al.   Fluids and Barriers of the CNS

Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow

(2020) Aniruddha Das et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes

(2020) Ashwini Hariharan et al.   Frontiers in Cellular Neuroscience

Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4

(2019) Chao Tan et al.   NEURON

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

(2019) Jean C. Cruz Hernández et al.   NATURE NEUROSCIENCE

Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice

(2019) Adam D. Hogan-Cann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Macrophages at CNS interfaces: ontogeny and function in health and disease

(2019) Katrin Kierdorf et al.   NATURE REVIEWS NEUROSCIENCE

Neurovascular Coupling in the Dentate Gyrus Regulates Adult Hippocampal Neurogenesis

(2019) Jia Shen et al.   NEURON

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses

(2019) Frank M Faraci et al.   CIRCULATION RESEARCH

Optogenetic assessment of VIP, PV, SOM and NOS inhibitory neuron activity and cerebral blood flow regulation in mouse somato-sensory cortex

(2019) Michael B Krawchuk et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas

(2019) Jaime Grutzendler et al.   TRENDS IN NEUROSCIENCES

Spatial Patterns of Decreased Cerebral Blood Flow and Functional Connectivity in Multiple System Atrophy (Cerebellar-Type): A Combined Arterial Spin Labeling Perfusion and Resting State Functional Magnetic Resonance Imaging Study

(2019) Weimin Zheng et al.   Frontiers in Neuroscience

Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons

(2019) L Lee et al.   CEREBRAL CORTEX

Emerging links between cerebrovascular and neurodegenerative diseases—a special role for pericytes

(2019) Urban Lendahl et al.   EMBO REPORTS

Dietary salt promotes cognitive impairment through tau phosphorylation

(2019) Giuseppe Faraco et al.   NATURE

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

(2019) Nina E. Fultz et al.   SCIENCE

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

(2019) Mette Mathiesen Janiurek et al.   eLife

Intercellular Conduction Optimizes Arterial Network Function and Conserves Blood Flow Homeostasis During Cerebrovascular Challenges

(2019) Anil Zechariah et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cerebrovascular function during cognition in Parkinson's disease: A functional transcranial Doppler sonography study

(2019) Daria S. Gutteridge et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

(2019) Susanne J. van Veluw et al.   NEURON

Cerebral oxygenation during locomotion is modulated by respiration

(2019) Qingguang Zhang et al.   Nature Communications

Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia

(2019) Takashi Koizumi et al.   Frontiers in Neuroscience

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS

(2018) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Neurovascular Communication during CNS Development

(2018) Isidora Paredes et al.   DEVELOPMENTAL CELL

The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease

(2018) Andreia G. Andrade et al.   JOURNAL OF ALZHEIMERS DISEASE

The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia

(2018) Mourad Belkhelfa et al.   JOURNAL OF NEUROIMMUNOLOGY

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Contribution of systemic vascular effects to fMRI activity in white matter

(2018) Pinar S. Özbay et al.   NEUROIMAGE

Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia

(2018) Ravi L. Rungta et al.   NEURON

Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

(2018) Changsi Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Inhibitory Neuron Activity Contributions to Hemodynamic Responses and Metabolic Load Examined Using an Inhibitory Optogenetic Mouse Model

(2018) Alberto L Vazquez et al.   CEREBRAL CORTEX

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Regulation of cerebral blood flow and metabolism during exercise

(2017) Kurt J. Smith et al.   EXPERIMENTAL PHYSIOLOGY

Molecular characterization of perivascular drainage pathways in the murine brain

(2017) Melanie-Jane Hannocks et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral artery myogenic reactivity: The next frontier in developing effective interventions for subarachnoid hemorrhage

(2017) Darcy Lidington et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

(2017) Roger I Grant et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex

(2017) Sinisa Hrvatin et al.   NATURE NEUROSCIENCE

Neural Circuitry of Wakefulness and Sleep

(2017) Thomas E. Scammell et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli

(2017) Daniel J. Green et al.   PHYSIOLOGICAL REVIEWS

Depth-dependent flow and pressure characteristics in cortical microvascular networks

(2017) Franca Schmid et al.   PLoS Computational Biology

Inflammation and vascular remodeling in the ventral hippocampus contributes to vulnerability to stress

(2017) J Pearson-Leary et al.   Translational Psychiatry

Neurovascular Coupling in Parkinson's Disease Patients: Effects of Dementia and Acetylcholinesterase Inhibitor Treatment

(2017) Bernhard Rosengarten et al.   JOURNAL OF ALZHEIMERS DISEASE

The capillary bed offers the largest hemodynamic resistance to the cortical blood supply

(2016) Ian Gopal Gould et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Orthostatic hypotension and cognitive impairment in Parkinson's disease: Causation or association?

(2016) Claire McDonald et al.   MOVEMENT DISORDERS

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

(2016) Helen Shinru Wei et al.   NEURON

Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states

(2016) C. Lecrux et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons

(2016) Ying Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

(2016) H.-H. Tsai et al.   SCIENCE

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Optogenetic Stimulation of GABA Neurons can Decrease Local Neuronal Activity While Increasing Cortical Blood Flow

(2015) Eitan Anenberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex

(2015) A. Lacroix et al.   JOURNAL OF NEUROSCIENCE

The impact of age on cerebral perfusion, oxygenation and metabolism during exercise in humans

(2015) Igor D. Braz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity

(2014) Nia C. S. Lewis et al.   JOURNAL OF APPLIED PHYSIOLOGY

Integrative regulation of human brain blood flow

(2014) Christopher K. Willie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

SPECT-imaging of activity-dependent changes in regional cerebral blood flow induced by electrical and optogenetic self-stimulation in mice

(2014) Angela Kolodziej et al.   NEUROIMAGE

Predictors of dementia in Parkinson disease: A prospective cohort study

(2014) J. B. M. Anang et al.   NEUROLOGY

Locus Coeruleus Stimulation Recruits a Broad Cortical Neuronal Network and Increases Cortical Perfusion

(2013) X. Toussay et al.   JOURNAL OF NEUROSCIENCE

Resolving the transition from negative to positive blood oxygen level-dependent responses in the developing brain

(2013) Mariel G. Kozberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast cells on the mind: new insights and opportunities

(2013) Rae Silver et al.   TRENDS IN NEUROSCIENCES

Endothelin 1–Dependent Neurovascular Dysfunction in Chronic Intermittent Hypoxia

(2012) Carmen Capone et al.   HYPERTENSION

The Locus Coeruleus-Norepinephrine Network Optimizes Coupling of Cerebral Blood Volume with Oxygen Demand

(2012) Lane K Bekar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regional brain blood flow in man during acute changes in arterial blood gases

(2012) C. K. Willie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neurovascular coupling and distribution of cerebral blood flow during exercise

(2011) C.K. Willie et al.   JOURNAL OF NEUROSCIENCE METHODS

Diurnal blood pressure variation and related behavioral factors

(2010) Yuhei Kawano   HYPERTENSION RESEARCH

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

(2010) Jin Hyung Lee et al.   NATURE

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

(2010) F. Fernandez-Klett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Body and brain temperature coupling: the critical role of cerebral blood flow

(2009) Mingming Zhu et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Anticipatory Changes in Regional Cerebral Hemodynamics: A New Role for Dopamine?

(2009) Can Ozan Tan   JOURNAL OF NEUROPHYSIOLOGY

Stimulus-Induced Changes in Blood Flow and 2-Deoxyglucose Uptake Dissociate in Ipsilateral Somatosensory Cortex

(2009) A. Devor et al.   JOURNAL OF NEUROSCIENCE

Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity

(2009) Yevgeniy B. Sirotin et al.   NATURE

Acute Hypertensive Response in Patients With Stroke

(2008) Adnan I. Qureshi   CIRCULATION

Theoretical Models for Regulation of Blood Flow

(2008) Timothy W. Secomb   MICROCIRCULATION