To be or not to be: endothelial cell plasticity in development, repair, and disease

Discovering New Progenitor Cell Populations through Lineage Tracing and In Vivo Imaging

(2020) Rudra Nayan Das et al.   Cold Spring Harbor Perspectives in Biology

Adult human vein grafts retain plasticity of vessel identity

(2020) Hualong Bai et al.   ANNALS OF VASCULAR SURGERY

Nfatc1 Promotes Interstitial Cell Formation During Cardiac Valve Development in Zebrafish

(2020) Felix Gunawan et al.   CIRCULATION RESEARCH

Live Imaging of Intracranial Lymphatics in the Zebrafish

(2020) Daniel Castranova et al.   CIRCULATION RESEARCH

Live imaging of angiogenesis during cutaneous wound healing in adult zebrafish

(2019) Chikage Noishiki et al.   ANGIOGENESIS

Impaired meningeal lymphatic vessel development worsens stroke outcome

(2019) Pavel Yanev et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Venous identity requires BMP signalling through ALK3

(2019) Alice Neal et al.   Nature Communications

Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom-Up versus Top-Down

(2019) Kristy Red-Horse et al.   BIOESSAYS

Cerebrovascular Injuries Induce Lymphatic Invasion into Brain Parenchyma to Guide Vascular Regeneration in Zebrafish

(2019) Jingying Chen et al.   DEVELOPMENTAL CELL

Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases

(2019) Sonsoles Piera-Velazquez et al.   PHYSIOLOGICAL REVIEWS

Cellular Plasticity in Cancer

(2019) Salina Yuan et al.   Cancer Discovery

Endothelial-to-Mesenchymal Transition (EndoMT): Roles in Tumorigenesis, Metastatic Extravasation and Therapy Resistance

(2019) Valentin Platel et al.   Journal of Oncology

TGF-β Signaling Promotes Tissue Formation during Cardiac Valve Regeneration in Adult Zebrafish

(2019) Anabela Bensimon-Brito et al.   DEVELOPMENTAL CELL

Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation

(2019) Rubén Marín-Juez et al.   DEVELOPMENTAL CELL

In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium

(2019) Laurent Yvernogeau et al.   NATURE CELL BIOLOGY

Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration

(2019) Michael RM Harrison et al.   eLife

Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration

(2019) Dana Gancz et al.   eLife

The Zebrafish Xenograft Platform—A Novel Tool for Modeling KSHV-Associated Diseases

(2019) Eric S. Pringle et al.   Viruses-Basel

Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult HeartNovelty and Significance

(2018) Juan Tang et al.   CIRCULATION RESEARCH

Meta-Analysis of Cell Therapy Studies in Heart Failure and Acute Myocardial Infarction

(2018) Mariann Gyöngyösi et al.   CIRCULATION RESEARCH

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

(2018) David B Gurevich et al.   EMBO JOURNAL

The zebrafish: A fintastic model for hematopoietic development and disease

(2018) Aniket V. Gore et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

(2018) Cécile Otten et al.   EMBO Molecular Medicine

Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos

(2018) Bart Weijts et al.   Nature Communications

Preexisting endothelial cells mediate cardiac neovascularization after injury

(2017) Lingjuan He et al.   JOURNAL OF CLINICAL INVESTIGATION

The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells

(2017) Ye Tian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish

(2017) Chao Liu et al.   JOURNAL OF LIPID RESEARCH

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues

(2017) Wade W. Sugden et al.   NATURE CELL BIOLOGY

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

(2017) Neil I Bower et al.   NATURE NEUROSCIENCE

NOTCH1 is a mechanosensor in adult arteries

(2017) Julia J. Mack et al.   Nature Communications

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

(2017) Jennifer S. Fang et al.   Nature Communications

The molecular basis of endothelial cell plasticity

(2017) Elisabetta Dejana et al.   Nature Communications

A novel perivascular cell population in the zebrafish brain

(2017) Marina Venero Galanternik et al.   eLife

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development

(2017) Max van Lessen et al.   eLife

Hemodynamic Control of Endothelial Cell Fates in Development

(2016) Guillermo García-Cardeña et al.   Annual Review of Cell and Developmental Biology

Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial InfarctionCLINICAL PERSPECTIVE

(2016) Orianne Henri et al.   CIRCULATION

Significance and therapeutic implications of endothelial progenitor cells in angiogenic-mediated tumour metastasis

(2016) Valentina Flamini et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Cellular plasticity: 1712 to the present day

(2016) Purushothama Rao Tata et al.   CURRENT OPINION IN CELL BIOLOGY

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

(2016) Sven Reischauer et al.   NATURE

Fast revascularization of the injured area is essential to support zebrafish heart regeneration

(2016) Rubén Marín-Juez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition

(2016) Luca Bravi et al.   STROKE

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Epithelial-to-endothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumors

(2016) Baocun Sun et al.   Oncotarget

Epigenetic regulation of hematopoiesis by DNA methylation

(2016) Aniket V Gore et al.   eLife

Endothelial Plasticity Drives Arterial Remodeling Within the Endocardium After Myocardial Infarction

(2015) L. Miquerol et al.   CIRCULATION RESEARCH

Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo

(2015) E. Butko et al.   DEVELOPMENT

Chemokine-Guided Angiogenesis Directs Coronary Vasculature Formation in Zebrafish

(2015) Michael R.M. Harrison et al.   DEVELOPMENTAL CELL

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

(2015) C. Liu et al.   Disease Models & Mechanisms

Notch signaling regulates venous arterialization during zebrafish fin regeneration

(2015) Yoshiko Kametani et al.   GENES TO CELLS

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Cardiac lymphatics are heterogeneous in origin and respond to injury

(2015) Linda Klotz et al.   NATURE

Lymphatic vessels arise from specialized angioblasts within a venous niche

(2015) J. Nicenboim et al.   NATURE

Notch signal strength controls cell fate in the haemogenic endothelium

(2015) Leonor Gama-Norton et al.   Nature Communications

Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish

(2015) Katarzyna Koltowska et al.   Cell Reports

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease

(2015) Fabian A. Mendoza et al.   Arthritis & Rheumatology

The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

(2014) H. I. Chen et al.   DEVELOPMENT

Divergence of zebrafish and mouse lymphatic cell fate specification pathways

(2014) A. van Impel et al.   DEVELOPMENT

SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish

(2014) Matthew R. Swift et al.   DEVELOPMENTAL BIOLOGY

The Prox1–Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors

(2014) R. Sathish Srinivasan et al.   GENES & DEVELOPMENT

Mesenchymal–endothelial transition contributes to cardiac neovascularization

(2014) Eric Ubil et al.   NATURE

Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels

(2014) Patrick A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration

(2014) L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arteries are formed by vein-derived endothelial tip cells

(2014) Cong Xu et al.   Nature Communications

Vascular development and hemodynamic force in the mouse yolk sac

(2014) Monica D. Garcia et al.   Frontiers in Physiology

Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development

(2013) Bhaskar Chanda et al.   CELL

Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish

(2013) Y. Albert Pan et al.   DEVELOPMENT

Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control

(2013) Kathrina L. Marcelo et al.   DEVELOPMENTAL CELL

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

‘Cancer associated fibroblasts’ – more than meets the eye

(2013) Shalom Madar et al.   TRENDS IN MOLECULAR MEDICINE

Arteriovenous Malformations and Other Vascular Malformation Syndromes

(2013) K. J. Whitehead et al.   Cold Spring Harbor Perspectives in Medicine

Vascular Development in the Zebrafish

(2013) A. V. Gore et al.   Cold Spring Harbor Perspectives in Medicine

Transdifferentiation of Fast Skeletal Muscle Into Functional Endothelium in Vivo by Transcription Factor Etv2

(2013) Matthew B. Veldman et al.   PLOS BIOLOGY

PRSS23 is essential for the Snail-dependent endothelial-to-mesenchymal transition during valvulogenesis in zebrafish

(2012) I-Hui Chen et al.   CARDIOVASCULAR RESEARCH

Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development

(2012) Victoria C. Garside et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish

(2012) K. S. Okuda et al.   DEVELOPMENT

Blood flow reprograms lymphatic vessels to blood vessels

(2012) Chiu-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis

(2011) Y. Zhang et al.   BLOOD

Circulating endothelial progenitor cells do not contribute to regeneration of endothelium after murine arterial injury

(2011) Mette K. Hagensen et al.   CARDIOVASCULAR RESEARCH

Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation

(2011) Bingruo Wu et al.   CIRCULATION RESEARCH

Distinct Cellular Mechanisms of Blood Vessel Fusion in the Zebrafish Embryo

(2011) Lukas Herwig et al.   CURRENT BIOLOGY

Interaction between alk1 and blood flow in the development of arteriovenous malformations

(2011) P. Corti et al.   DEVELOPMENT

Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling

(2011) J. Bussmann et al.   DEVELOPMENT

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

(2011) Bilge Yoruk et al.   DEVELOPMENTAL BIOLOGY

Progenitor Cells Confer Plasticity to Cardiac Valve Endothelium

(2011) Joyce Bischoff et al.   Journal of Cardiovascular Translational Research

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

(2010) E. Y. N. Lam et al.   BLOOD

Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish

(2010) C. Mosimann et al.   DEVELOPMENT

Notch1activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants

(2010) Luke T. Krebs et al.   GENESIS

CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

(2010) Xiangjian Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved

(2010) C. Soza-Ried et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autologous stem cell therapy for peripheral arterial disease

(2009) Gian Paolo Fadini et al.   ATHEROSCLEROSIS

Bone marrow-derived cells are not involved in reendothelialized endothelium as endothelial cells after simple endothelial denudation in mice

(2009) Michitaka Tsuzuki   BASIC RESEARCH IN CARDIOLOGY

Active Adaptation of the Tethered Mitral Valve

(2009) Jacob P. Dal-Bianco et al.   CIRCULATION

Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish

(2009) Konstantin Stoletov et al.   CIRCULATION RESEARCH

Vascular morphogenesis in the zebrafish embryo

(2009) Elín Ellertsdóttir et al.   DEVELOPMENTAL BIOLOGY

Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development

(2009) Mohamad Azhar et al.   DEVELOPMENTAL DYNAMICS

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation

(2009) Y. K. Lieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis

(2008) L. C. Goldie et al.   BLOOD

Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors

(2008) Sarah De Val et al.   CELL

ER71 Acts Downstream of BMP, Notch, and Wnt Signaling in Blood and Vessel Progenitor Specification

(2008) Dongjun Lee et al.   Cell Stem Cell

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1

(2008) Àlex Robert-Moreno et al.   EMBO JOURNAL

Oncogenic KRAS Induces Progenitor Cell Expansion and Malignant Transformation in Zebrafish Exocrine Pancreas

(2008) Seung Woo Park et al.   GASTROENTEROLOGY

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity

(2008) N. C. Johnson et al.   GENES & DEVELOPMENT

Activation of Akt through gp130 Receptor Signaling Is Required for Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphatic Reprogramming of Endothelial Cells

(2008) V. A. Morris et al.   JOURNAL OF VIROLOGY