Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C

Endothelial nitric oxide synthase deficient mice: a model of spontaneous cerebral small vessel disease

(2021) Francesca-Fang Liao et al.   AMERICAN JOURNAL OF PATHOLOGY

Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function

(2020) Ying Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated protein C and PAR1‐derived and PAR3‐derived peptides are anti‐inflammatory by suppressing macrophage NLRP3 inflammasomes

(2020) Laura D. Healy et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

(2019) Divna Lazic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small vessel disease: mechanisms and clinical implications

(2019) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Promoting Neuro‐Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels

(2019) Su Jing Chan et al.   Stem Cells Translational Medicine

White Matter Stroke Induces a Unique Oligo-Astrocyte Niche That Inhibits Recovery

(2019) Elif G. Sozmen et al.   JOURNAL OF NEUROSCIENCE

Cerebral small vessel disease and the risk of dementia: A systematic review and meta-analysis of population-based evidence

(2018) Daniel Bos et al.   Alzheimers & Dementia

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

(2018) Ranjeet K. Sinha et al.   BLOOD

Activated protein C, protease activated receptor 1, and neuroprotection

(2018) John H. Griffin et al.   BLOOD

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Mechanisms of demyelination and remyelination in the young and aged brain following white matter stroke

(2018) Miguel Alejandro Marin et al.   NEUROBIOLOGY OF DISEASE

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Cerebrovascular Alterations in Alzheimer Disease

(2018) Costantino Iadecola et al.   CIRCULATION RESEARCH

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Stroke in CNS white matter: Models and mechanisms

(2018) Miguel Alejandro Marin et al.   NEUROSCIENCE LETTERS

Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activ

(2018) Patrick Lyden et al.   ANNALS OF NEUROLOGY

Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood–brain barrier permeability in the corpus callosum

(2017) Qinghai Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier StabilizationSignificance

(2016) Ranjeet K. Sinha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in ThrombosisHighlights

(2016) John H. Griffin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activated protein C binds directly to Tie2: possible beneficial effects on endothelial barrier function

(2016) Nikita Minhas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

3K3A–activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice

(2016) Yaoming Wang et al.   NATURE MEDICINE

Disruptions of network connectivity predict impairment in multiple behavioral domains after stroke

(2016) Joshua Sarfaty Siegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice

(2016) Elif G. Sozmen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

White matter injury in ischemic stroke

(2016) Yuan Wang et al.   PROGRESS IN NEUROBIOLOGY

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

(2015) Mitrajit Ghosh et al.   ANNALS OF NEUROLOGY

Activated protein C: biased for translation

(2015) J. H. Griffin et al.   BLOOD

Experimental model of small subcortical infarcts in mice with long-lasting functional disabilities

(2015) Hiroki Uchida et al.   BRAIN RESEARCH

CNS Myelin Wrapping Is Driven by Actin Disassembly

(2015) J. Bradley Zuchero et al.   DEVELOPMENTAL CELL

The thrombin receptor is a critical extracellular switch controlling myelination

(2015) Hyesook Yoon et al.   GLIA

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

What are White Matter Hyperintensities Made of? Relevance to Vascular Cognitive Impairment

(2015) Joanna M. Wardlaw et al.   Journal of the American Heart Association

Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats

(2015) Madelaine Daianu et al.   PLoS One

Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity

(2014) F. Stavenuiter et al.   BLOOD

Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

(2014) Patrick Lyden et al.   CURRENT PHARMACEUTICAL DESIGN

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

(2013) L. Burnier et al.   BLOOD

An Activated Protein C Analog Stimulates Neuronal Production by Human Neural Progenitor Cells via a PAR1-PAR3-S1PR1-Akt Pathway

(2013) H. Guo et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Exacerbation of White Matter Stroke Outcomes

(2013) Shira Rosenzweig et al.   STROKE

Activated Protein C Analog Protects From Ischemic Stroke and Extends the Therapeutic Window of Tissue-Type Plasminogen Activator in Aged Female Mice and Hypertensive Rats

(2013) Yaoming Wang et al.   STROKE

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke

(2012) Patricia D. Williams et al.   CURRENT PHARMACEUTICAL DESIGN

Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects

(2012) R. A. SCHUEPBACH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

An Activated Protein C Analog With Reduced Anticoagulant Activity Extends the Therapeutic Window of Tissue Plasminogen Activator for Ischemic Stroke in Rodents

(2012) Yaoming Wang et al.   STROKE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Protecting White Matter From Stroke Injury

(2012) Carlos Matute et al.   STROKE

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of White Matter Lesions on Physical Functioning and Fall Risk in Older People

(2011) Jacqueline J.J. Zheng et al.   STROKE

Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact

(2010) Corey T. Walker et al.   BRAIN RESEARCH

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

(2010) Chunzhang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

(2009) Huang Guo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

(2009) Zhihui Zhong et al.   JOURNAL OF CLINICAL INVESTIGATION

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity

(2009) Huang Guo et al.   JOURNAL OF NEUROCHEMISTRY

A white matter stroke model in the mouse: Axonal damage, progenitor responses and MRI correlates

(2009) Elif G. Sozmen et al.   JOURNAL OF NEUROSCIENCE METHODS

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE