Intrathecal delivery and its applications in leptomeningeal disease

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

(2022) Mehmet Sait Albayram et al.   Nature Communications

Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics

(2021) Steven T. Proulx   CELLULAR AND MOLECULAR LIFE SCIENCES

Harnessing Cerebrospinal Fluid Circulation for Drug Delivery to Brain Tissues

(2021) Ghazal Naseri Kouzehgarani et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular mechanisms of brain water transport

(2021) Nanna MacAulay   NATURE REVIEWS NEUROSCIENCE

Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis

(2021) Mootaz M. Salman et al.   NATURE REVIEWS NEUROSCIENCE

Prophylaxis with intrathecal or high-dose methotrexate in diffuse large B-cell lymphoma and high risk of CNS relapse

(2021) Sabela Bobillo et al.   Blood Cancer Journal

Intrathecal drug delivery in the era of nanomedicine

(2020) M. Fowler et al.   ADVANCED DRUG DELIVERY REVIEWS

Meningeal lymphatic vessels regulate brain tumor drainage and immunity

(2020) Xueting Hu et al.   CELL RESEARCH

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Perivascular spaces in the brain: anatomy, physiology and pathology

(2020) Joanna M. Wardlaw et al.   Nature Reviews Neurology

Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy

(2020) Diane E. Frank et al.   NEUROLOGY

Single-center phase I/Ib study of concurrent intrathecal (IT) and intravenous (IV) nivolumab (N) for metastatic melanoma (MM) patients (pts) with leptomeningeal disease (LMD).

(2020) Isabella Claudia Glitza et al.   JOURNAL OF CLINICAL ONCOLOGY

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

(2020) Johanna Theruvath et al.   NATURE MEDICINE

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

(2020) Laura K. Donovan et al.   NATURE MEDICINE

The Brain’s Glymphatic System: Current Controversies

(2020) Humberto Mestre et al.   TRENDS IN NEUROSCIENCES

Comparison of high-dose intracisterna magna and lumbar puncture intrathecal delivery of AAV9 in mice to treat neuropathies

(2020) Rachel M. Bailey et al.   BRAIN RESEARCH

Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

(2020) Jenna M. Sullivan et al.   Journal of Translational Medicine

Circadian control of brain glymphatic and lymphatic fluid flow

(2020) Lauren M. Hablitz et al.   Nature Communications

Direct Measurement of Cerebrospinal Fluid Production in Mice

(2020) Guojun Liu et al.   Cell Reports

Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells

(2019) Martin Hsu et al.   Nature Communications

Characterization of intrathecal cerebrospinal fluid geometry and dynamics in cynomolgus monkeys (macaca fascicularis) by magnetic resonance imaging

(2019) Mohammadreza Khani et al.   PLoS One

Glymphatic System Function in Relation to Anesthesia and Sleep States

(2019) Helene Benveniste et al.   ANESTHESIA AND ANALGESIA

Intrathecal enzyme replacement for Hurler syndrome: biomarker association with neurocognitive outcomes

(2019) Julie B. Eisengart et al.   GENETICS IN MEDICINE

Guest Editorial: Physician Guidance on the Use of Off‐Labeled Drugs in Intrathecal Drug Delivery Systems for Chronic Pain

(2019) Timothy Deer et al.   NEUROMODULATION

Targeting Huntingtin Expression in Patients with Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Configuration of the Perivascular System Transporting Macromolecules in the CNS

(2019) Beata Durcanova et al.   Frontiers in Neuroscience

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

Hydraulic resistance of periarterial spaces in the brain

(2019) Jeffrey Tithof et al.   Fluids and Barriers of the CNS

An Integrated Safety Analysis of Infants and Children with Symptomatic Spinal Muscular Atrophy (SMA) Treated with Nusinersen in Seven Clinical Trials

(2019) Basil T. Darras et al.   CNS DRUGS

Biodistribution and Dosimetry of Intraventricularly Administered 124I-Omburtamab in Patients with Metastatic Leptomeningeal Tumors

(2019) Neeta Pandit-Taskar et al.   JOURNAL OF NUCLEAR MEDICINE

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

(2019) Julia F. Alterman et al.   NATURE BIOTECHNOLOGY

Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study

(2019) Darryl C. De Vivo et al.   NEUROMUSCULAR DISORDERS

Fluid dynamics of cerebrospinal fluid flow in perivascular spaces

(2019) John H. Thomas   Journal of the Royal Society Interface

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

(2019) Paulina D. Ramírez-García et al.   Nature Nanotechnology

Anatomy and function of the vertebral column lymphatic network in mice

(2019) Laurent Jacob et al.   Nature Communications

Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice

(2019) K. T. Householder et al.   Scientific Reports

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

Leptomeningeal Metastases

(2018) Jerome J. Graber et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

The Glymphatic System and Waste Clearance with Brain Aging: A Review

(2018) Helene Benveniste et al.   GERONTOLOGY

Evaluation of Intrathecal Routes of Administration for Adeno-Associated Viral Vectors in Large Animals

(2018) Christian Hinderer et al.   HUMAN GENE THERAPY

Anthropomorphic Model of Intrathecal Cerebrospinal Fluid Dynamics Within the Spinal Subarachnoid Space: Spinal Cord Nerve Roots Increase Steady-Streaming

(2018) Mohammadreza Khani et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Study of Intraventricular Cerliponase Alfa for CLN2 Disease

(2018) Angela Schulz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides

(2018) Shiyu Wang et al.   NUCLEIC ACIDS RESEARCH

Advances in Meningeal Immunity

(2018) Rejane Rua et al.   TRENDS IN MOLECULAR MEDICINE

Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells

(2018) Anandani Nellan et al.   Journal for ImmunoTherapy of Cancer

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Leptomeningeal metastasis from solid tumors: clinical features and its diagnostic implication

(2018) Zhenyu Pan et al.   Scientific Reports

Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI

(2018) Ian F Harrison et al.   eLife

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

CMET-39. INTRA-CSF LIPOSOMAL CYTARABINE PLUS SYSTEMIC THERAPY AS INITIAL TREATMENT OF BREAST CANCER LEPTOMENINGEAL METASTASIS: A RANDOMISED, OPEN-LABEL TRIAL

(2018) Emilie Le Rhun et al.   NEURO-ONCOLOGY

Intrathecal treatment trial of rituximab in progressive MS

(2018) Joakim Bergman et al.   NEUROLOGY

The Meningeal Lymphatic System: A New Player in Neurophysiology

(2018) Sandro Da Mesquita et al.   NEURON

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

(2018) Amber L. Southwell et al.   Science Translational Medicine

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system

(2017) Huixia Ren et al.   FASEB JOURNAL

Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disorders

(2017) K Bey et al.   GENE THERAPY

Direct numerical simulation of transitional hydrodynamics of the cerebrospinal fluid in Chiari I malformation: The role of cranio-vertebral junction

(2017) Kartik Jain et al.   International Journal for Numerical Methods in Biomedical Engineering

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and plasticity of meningeal lymphatic vessels

(2017) Salli Antila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bypassing the barrier: new routes for delivery of macromolecules to the central nervous system

(2017) Shane Liddelow   JOURNAL OF PHYSIOLOGY-LONDON

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacokinetics of an intracerebroventricularly administered antibody in rats

(2017) Yuki Noguchi et al.   mAbs

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Leptomeningeal disease: current diagnostic and therapeutic strategies

(2017) Gautam Nayar et al.   Oncotarget

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma

(2017) Nabil Ahmed et al.   JAMA Oncology

A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space

(2017) Per Thomas Haga et al.   PLoS One

CCR7 deficient inflammatory Dendritic Cells are retained in the Central Nervous System

(2017) Benjamin D. Clarkson et al.   Scientific Reports

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

(2016) Matthew J. Simon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

Concurrent radiotherapy and intrathecal methotrexate for treating leptomeningeal metastasis from solid tumors with adverse prognostic factors: A prospective and single-arm study

(2016) Zhenyu Pan et al.   INTERNATIONAL JOURNAL OF CANCER

Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

(2016) Richard S Finkel et al.   LANCET

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

(2016) Thiyagaragan M. Achariyar et al.   Molecular Neurodegeneration

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

(2016) Christine E. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cerebrospinal fluid secretion by the choroid plexus?

(2016) Darko Orešković et al.   PHYSIOLOGICAL REVIEWS

Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system

(2016) Maosheng Xia et al.   PSYCHOPHARMACOLOGY

Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control

(2016) C Luo et al.   Cell Death & Disease

Intrathecal chemotherapy as a treatment for leptomeningeal metastasis of non-small cell lung cancer: A pooled analysis

(2016) Ya-Lan Wu et al.   Oncology Letters

Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices

(2016) Juan A. Varela et al.   Nature Communications

Cerebellomedullary Cistern Delivery for AAV-Based Gene Therapy: A Technical Note for Nonhuman Primates

(2016) Lluis Samaranch et al.   Human Gene Therapy Methods

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

Efficient central nervous system AAVrh10-mediated intrathecal gene transfer in adult and neonate rats

(2015) J Hordeaux et al.   GENE THERAPY

A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II

(2015) Joseph Muenzer et al.   GENETICS IN MEDICINE

CNS wide simulation of flow resistance and drug transport due to spinal microanatomy

(2015) Kevin M. Tangen et al.   JOURNAL OF BIOMECHANICS

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inspiration Is the Major Regulator of Human CSF Flow

(2015) S. Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

A novel method to study cerebrospinal fluid dynamics in rats

(2015) Jason K. Karimy et al.   JOURNAL OF NEUROSCIENCE METHODS

Novel Polymeric Bioerodable Microparticles for Prolonged-Release Intrathecal Delivery of Analgesic Agents for Relief of Intractable Cancer-Related Pain

(2015) Felicity Y. Han et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Determination of the role of injection site on the efficacy of intra-CSF enzyme replacement therapy in MPS IIIA mice

(2015) Helen Beard et al.   MOLECULAR GENETICS AND METABOLISM

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages

(2015) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Translational Fidelity of Intrathecal Delivery of Self-Complementary AAV9–Survival Motor Neuron 1 for Spinal Muscular Atrophy

(2014) Marco A. Passini et al.   HUMAN GENE THERAPY

Numerical simulations of the pulsating flow of cerebrospinal fluid flow in the cervical spinal canal of a Chiari patient

(2014) Anders Helgeland et al.   JOURNAL OF BIOMECHANICS

Safety of Ommaya reservoirs in children with brain tumors: a 20-year experience with 5472 intraventricular drug administrations in 98 patients

(2014) Andreas Peyrl et al.   JOURNAL OF NEURO-ONCOLOGY

Intrathecal delivery of protein therapeutics to the brain: A critical reassessment

(2014) Pericles Calias et al.   PHARMACOLOGY & THERAPEUTICS

Immunophenotyping of Cerebrospinal Fluid Cells in Multiple Sclerosis

(2014) Sascha Alvermann et al.   JAMA Neurology

Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer: a systematic review and pooled analysis

(2013) Flora Zagouri et al.   BREAST CANCER RESEARCH AND TREATMENT

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

(2013) S J Gray et al.   GENE THERAPY

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Ommaya reservoir infections: A 16-year retrospective analysis

(2013) Peter A. Mead et al.   JOURNAL OF INFECTION

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

(2013) Lijun Yang et al.   Journal of Translational Medicine

Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS

(2013) Mikhail I. Papisov et al.   MOLECULAR PHARMACEUTICS

The Frequency and Magnitude of Cerebrospinal Fluid Pulsations Influence Intrathecal Drug Distribution

(2012) Ying Hsu et al.   ANESTHESIA AND ANALGESIA

Surprising outcome of ommaya reservoir in treating cystic craniopharyngioma: a retrospective study

(2012) A. H. Moussa et al.   BRITISH JOURNAL OF NEUROSURGERY

Migration of monocytes after intracerebral injection at entorhinal cortex lesion site

(2012) Miriam Kaminski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In Vivo Distribution and Toxicity of PAMAM Dendrimers in the Central Nervous System Depend on Their Surface Chemistry

(2012) Lorenzo Albertazzi et al.   MOLECULAR PHARMACEUTICS

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

(2012) Holly B. Kordasiewicz et al.   NEURON

Intracisternal enzyme replacement therapy in lysosomal storage diseases: dispersal pathways, regional enzyme concentrations and the effect of posttreatment posture

(2012) R. D. Jolly et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder

(2012) Pericles Calias et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Outcome after whole brain radiotherapy alone in intracranial leptomeningeal carcinomatosis from solid tumors

(2012) C. Gani et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Complete response in HER2+ leptomeningeal carcinomatosis from breast cancer with intrathecal trastuzumab

(2011) Mafalda Oliveira et al.   BREAST CANCER RESEARCH AND TREATMENT

Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs

(2011) T Federici et al.   GENE THERAPY

Comparison of Adeno-Associated Viral Vector Serotypes for Spinal Cord and Motor Neuron Gene Delivery

(2011) Brooke R. Snyder et al.   HUMAN GENE THERAPY

Leptomeningeal Metastasis from Non-small Cell Lung Cancer: Survival and the Impact of Whole Brain Radiotherapy

(2011) Patrick G. Morris et al.   Journal of Thoracic Oncology

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular Atrophy

(2011) M. A. Passini et al.   Science Translational Medicine

Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice

(2010) Noel C. Derecki et al.   BRAIN BEHAVIOR AND IMMUNITY

Microvascular fluid exchange and the revised Starling principle

(2010) J. Rodney Levick et al.   CARDIOVASCULAR RESEARCH

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrathecal gene therapy for treatment of leptomeningeal carcinomatosis

(2010) John D. Heiss et al.   JOURNAL OF NEURO-ONCOLOGY

Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs

(2010) Andreas Kuttler et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Cerebrospinal fluid dynamics in the human cranial subarachnoid space: an overlooked mediator of cerebral disease. I. Computational model

(2010) S. Gupta et al.   Journal of the Royal Society Interface

Intrathecal chemotherapy for treatment of leptomeningeal dissemination of metastatic tumours

(2010) Patrick Beauchesne   LANCET ONCOLOGY

Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I

(2010) Patricia I. Dickson et al.   MOLECULAR GENETICS AND METABOLISM

Leptomeningeal metastases in the MRI era

(2010) J. L. Clarke et al.   NEUROLOGY

Intracisternal enzyme replacement therapy in lysosomal storage diseases: routes of absorption into brain

(2010) R. D. Jolly et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Epithelial Pathways in Choroid Plexus Electrolyte Transport

(2010) Helle H. Damkier et al.   PHYSIOLOGY

Gene transfer using self-assembled ternary complexes of cationic magnetic nanoparticles, plasmid DNA and cell-penetrating Tat peptide

(2009) Hai Peng Song et al.   BIOMATERIALS

A Phase-Contrast MRI Study of Physiologic Cerebral Venous Flow

(2009) Souraya Stoquart-ElSankari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Compartmental intrathecal radioimmunotherapy: results for treatment for metastatic CNS neuroblastoma

(2009) Kim Kramer et al.   JOURNAL OF NEURO-ONCOLOGY

DNA-Based MRI Probes for Specific Detection of Chronic Exposure to Amphetamine in Living Brains

(2009) C. H. Liu et al.   JOURNAL OF NEUROSCIENCE

Effect of cisternal sulfamidase delivery in MPS IIIA Huntaway dogs—A proof of principle study

(2009) Kim M. Hemsley et al.   MOLECULAR GENETICS AND METABOLISM

Targeting activated microglia in Alzheimer's pathology by intraventricular delivery of a phagocytosable MRI contrast agent in APP23 transgenic mice

(2009) Adrian P. Mundt et al.   NEUROIMAGE

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Intrathecal trastuzumab (Herceptin) and methotrexate for meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer: a case report

(2008) Hans-Joachim Stemmler et al.   ANTI-CANCER DRUGS

In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: Quantification of labeled cell phenotype

(2008) James P. Sumner et al.   NEUROIMAGE