CSF, blood-brain barrier, and brain drug delivery

A balanced view of choroid plexus structure and function: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

(2015) William M Pardridge   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeted delivery of protein and gene medicines through the blood-brain barrier

(2015) WM Pardridge   CLINICAL PHARMACOLOGY & THERAPEUTICS

Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB

(2014) S.-h. Kan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

(2014) Norman R. Saunders et al.   Frontiers in Neuroscience

Effects of baclofen on mechanical noxious and innocuous transmission in the spinal dorsal horn of the adult rat:in vivopatch-clamp analysis

(2013) Kaori Fukuhara et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

N- and L-Type Voltage-Dependent Ca2+ Channels Contribute to the Generation of After-Discharges in the Spinal Ventral Root After Cessation of Noxious Mechanical Stimulation

(2012) Shohei Yamamoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder

(2012) Pericles Calias et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion

(2011) Robin J. Ziegler et al.   EXPERIMENTAL NEUROLOGY

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

(2010) M. Friden et al.   DRUG METABOLISM AND DISPOSITION

Morphometry of the human cerebral cortex microcirculation: General characteristics and space-related profiles

(2007) Frederic Lauwers et al.   NEUROIMAGE