A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space

Poro-elastic modeling of Syringomyelia – a systematic study of the effects of pia mater, central canal, median fissure, white and gray matter on pressure wave propagation and fluid movement within the cervical spinal cord

(2015) Karen H. Støverud et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

CNS wide simulation of flow resistance and drug transport due to spinal microanatomy

(2015) Kevin M. Tangen et al.   JOURNAL OF BIOMECHANICS

Inspiration Is the Major Regulator of Human CSF Flow

(2015) S. Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

$1-million price tag set for Glybera gene therapy

(2015) Chris Morrison   NATURE BIOTECHNOLOGY

Pharmacokinetics and Bioavailability of a Therapeutic Enzyme (Idursulfase) in Cynomolgus Monkeys after Intrathecal and Intravenous Administration

(2015) Hongsheng Xie et al.   PLoS One

Clinical Relevance of Pharmacological and Physiological Data in Intrathecal Baclofen Therapy

(2014) Herre W. Heetla et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Developments in treatments for amyotrophic lateral sclerosis via intracerebroventricular or intrathecal delivery

(2014) Philip Van Damme et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effects of fluid structure interaction in a three dimensional model of the spinal subarachnoid space

(2014) Shaokoon Cheng et al.   JOURNAL OF BIOMECHANICS

The Impact of Spinal Cord Nerve Roots and Denticulate Ligaments on Cerebrospinal Fluid Dynamics in the Cervical Spine

(2014) Soroush Heidari Pahlavian et al.   PLoS One

Pulsatile Viscous Flows in Elliptical Vessels and Annuli: Solution to the Inverse Problem, with Application to Blood and Cerebrospinal Fluid Flow

(2014) Luigi C. Berselli et al.   SIAM JOURNAL ON APPLIED MATHEMATICS

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

(2013) S J Gray et al.   GENE THERAPY

Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS

(2013) Mikhail I. Papisov et al.   MOLECULAR PHARMACEUTICS

Patients with a History of Spine Surgery or Spinal Injury may have a Higher Chance of Intrathecal Catheter Granuloma Formation

(2013) Samer N. Narouze et al.   Pain Practice

The Frequency and Magnitude of Cerebrospinal Fluid Pulsations Influence Intrathecal Drug Distribution

(2012) Ying Hsu et al.   ANESTHESIA AND ANALGESIA

CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder

(2012) Pericles Calias et al.   PLoS One

Comparison of 4D Phase-Contrast MRI Flow Measurements to Computational Fluid Dynamics Simulations of Cerebrospinal Fluid Motion in the Cervical Spine

(2012) Theresia I. Yiallourou et al.   PLoS One

Effects of Flow Rate Modifications on Reported Analgesia and Quality of Life in Chronic Pain Patients Treated with Continuous Intrathecal Drug Therapy

(2011) Christophe Perruchoud et al.   PAIN MEDICINE

Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics

(2010) Ryan G Soderquist et al.   Expert Opinion on Drug Delivery

Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs

(2010) Andreas Kuttler et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Cerebrospinal fluid dynamics in the human cranial subarachnoid space: an overlooked mediator of cerebral disease. I. Computational model

(2010) S. Gupta et al.   Journal of the Royal Society Interface

Cerebrospinal Fluid and Spinal Cord Distribution of Hyperbaric Bupivacaine and Baclofen during Slow Intrathecal Infusion in Pigs

(2009) Sean H. Flack et al.   ANESTHESIOLOGY

A self-adaptive oriented particles Level-Set method for tracking interfaces

(2009) S. Ianniello et al.   JOURNAL OF COMPUTATIONAL PHYSICS

Three-Dimensional Computational Modeling of Subject-Specific Cerebrospinal Fluid Flow in the Subarachnoid Space

(2008) Sumeet Gupta et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Computational methods for predicting drug transport in anisotropic and heterogeneous brain tissue

(2008) Andreas A. Linninger et al.   JOURNAL OF BIOMECHANICS