Vascular, glial, and lymphatic immune gateways of the central nervous system

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Postarrest stalling rather than crawling favors CD8+ over CD4+ T-cell migration across the blood-brain barrier under flow in vitro

(2016) Henriette Rudolph et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels

(2016) Erica Russo et al.   Cell Reports

Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

(2015) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity

(2015) Klaus Lehmann-Horn et al.   ANNALS OF NEUROLOGY

Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin

(2015) Guillaume Martin-Blondel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Are you also what your mother eats? Distinct proteomic portrait as a result of maternal high-fat diet in the cerebral cortex of the adult mouse

(2015) A Manousopoulou et al.   INTERNATIONAL JOURNAL OF OBESITY

Lymphatic vessels of the dura mater: a new discovery?

(2015) Fabio Bucchieri et al.   JOURNAL OF ANATOMY

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inspiration Is the Major Regulator of Human CSF Flow

(2015) S. Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

Prenatal high-fat diet alters the cerebrovasculature and clearance ofβ-amyloid in adult offspring

(2015) Cheryl A Hawkes et al.   JOURNAL OF PATHOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Oligodendrocyte death results in immune-mediated CNS demyelination

(2015) Maria Traka et al.   NATURE NEUROSCIENCE

Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space

(2015) Owain W. Howell et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

White Matter Changes in Dementia: Role of Impaired Drainage of Interstitial Fluid

(2014) Roy O. Weller et al.   BRAIN PATHOLOGY

PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE

(2014) Karthik Sathiyanadan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Emerging roles of lymphatic endothelium in regulating adaptive immunity

(2014) Catherine M. Card et al.   JOURNAL OF CLINICAL INVESTIGATION

Swift Entry of Myelin-Specific T Lymphocytes into the Central Nervous System in Spontaneous Autoimmune Encephalomyelitis

(2014) G. C. Furtado et al.   JOURNAL OF IMMUNOLOGY

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

(2014) Miguel Pappolla et al.   NEUROBIOLOGY OF DISEASE

Street-Experienced Peripheral B Cells Traffic to the Brain

(2014) D. R. Lu et al.   Science Translational Medicine

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

Antigen-specific immune reactions to ischemic stroke

(2014) Xabier Urra et al.   Frontiers in Cellular Neuroscience

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy

(2014) Alan W. J. Morris et al.   Frontiers in Aging Neuroscience

Immunophenotyping of Cerebrospinal Fluid Cells in Multiple Sclerosis

(2014) Sascha Alvermann et al.   JAMA Neurology

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

(2013) Cheryl A. Hawkes et al.   AGING CELL

Afferent and efferent immunological pathways of the brain. Anatomy, Function and Failure

(2013) R.O. Carare et al.   BRAIN BEHAVIOR AND IMMUNITY

Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis

(2013) Danielle Califano et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Drainage of Cells and Soluble Antigen from the CNS to Regional Lymph Nodes

(2013) Jon D. Laman et al.   Journal of Neuroimmune Pharmacology

Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator

(2013) Marsilius Mues et al.   NATURE MEDICINE

A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity

(2013) Dmitri Lodygin et al.   NATURE MEDICINE

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy

(2013) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Laminin isoforms in endothelial and perivascular basement membranes

(2013) Lema F. Yousif et al.   Cell Adhesion & Migration

Update on Immune Mechanisms Associated with Sublingual Immunotherapy: Practical Implications for the Clinician

(2013) Philippe Moingeon   Journal of Allergy and Clinical Immunology-In Practice

Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease

(2013) Roxana Carare et al.   Acta Neuropathologica Communications

Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation

(2012) M. Nitschke et al.   BLOOD

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

Brain-Derived Antigens in Lymphoid Tissue of Patients with Acute Stroke

(2012) A. M. Planas et al.   JOURNAL OF IMMUNOLOGY

Migration of monocytes after intracerebral injection at entorhinal cortex lesion site

(2012) Miriam Kaminski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

T cells become licensed in the lung to enter the central nervous system

(2012) Francesca Odoardi et al.   NATURE

Primary oligodendrocyte death does not elicit anti-CNS immunity

(2012) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

(2011) Yoko Okamoto et al.   ACTA NEUROPATHOLOGICA

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Role of ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions

(2011) Igal Ifergan et al.   ANNALS OF NEUROLOGY

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

(2011) A. Saxena et al.   FEBS LETTERS

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

(2011) Lillian Cruz-Orengo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression

(2010) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

 4 1 Integrin Mediates the Recruitment of Immature Dendritic Cells across the Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis

(2010) P. Jain et al.   JOURNAL OF IMMUNOLOGY

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

(2009) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Cervical lymph nodes are found in direct relationship with the internal carotid artery: Significance for the lymphatic drainage of the brain

(2009) R. Clapham et al.   CLINICAL ANATOMY

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

(2008) Marloes van Zwam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic-relapsing experimental autoimmune encephalomyelitis

(2008) Marloes van Zwam et al.   JOURNAL OF PATHOLOGY

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

(2008) Hekla Sigmundsdottir et al.   NATURE IMMUNOLOGY

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS

Cerebrospinal Fluid Dendritic Cells Infiltrate the Brain Parenchyma and Target the Cervical Lymph Nodes under Neuroinflammatory Conditions

(2008) Eric Hatterer et al.   PLoS One