The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

(2021) Tom Hodgkinson et al.   Science Advances

Electric field-driven building blocks for introducing multiple gradients to hydrogels

(2020) Gang Xu et al.   Protein & Cell

Scaffolds for Knee Chondral and Osteochondral Defects: Indications for Different Clinical Scenarios. A Consensus Statement

(2020) Giuseppe Filardo et al.   Cartilage

Early Changes in Cartilage Pericellular Matrix Micromechanobiology Portend the Onset of Post-Traumatic Osteoarthritis

(2020) Daphney R. Chery et al.   Acta Biomaterialia

Ex vivo models of musculoskeletal tissues

(2020) Spencer E. Szczesny   CONNECTIVE TISSUE RESEARCH

Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis

(2020) Zhenxing Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gradient Hydrogels for Optimizing Niche Cues to Enhance Cell-Based Cartilage Regeneration

(2020) Elisa Liu et al.   TISSUE ENGINEERING PART A

The interactions between mTOR and NF‐κB: A novel mechanism mediating mechanical stretch‐stimulated osteoblast differentiation

(2020) Dan Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of microRNA-3085 in chondrocyte function

(2020) Linh Le et al.   Scientific Reports

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

(2019) Song Ho Chang et al.   Nature Communications

Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage

(2019) M. Danalache et al.   OSTEOARTHRITIS AND CARTILAGE

Primary cilia and autophagy interaction is involved in mechanical stress mediated cartilage development via ERK/mTOR axis

(2019) Wei Xiang et al.   LIFE SCIENCES

Optimization of Photocrosslinked Gelatin/Hyaluronic Acid Hybrid Scaffold for the repair of cartilage defect

(2019) Hang Lin et al.   Journal of Tissue Engineering and Regenerative Medicine

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation

(2019) Anne Laugesen et al.   MOLECULAR CELL

Longitudinal Effects of Acute Anterior Cruciate Ligament Tears on Peri‐Articular Bone in Human Knees Within the First Year of Injury

(2019) Andres Kroker et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Excessive mechanical stress induces chondrocyte apoptosis through TRPV4 in an anterior cruciate ligament-transected rat osteoarthritis model

(2019) Bo Xu et al.   LIFE SCIENCES

Mechanical Stretch Promotes the Osteogenic Differentiation of Bone Mesenchymal Stem Cells Induced by Erythropoietin

(2019) Yong-Bin He et al.   Stem Cells International

Mechanical stimulation promotes the proliferation and the cartilage phenotype of mesenchymal stem cells and chondrocytes co-cultured in vitro

(2019) Xinli Ouyang et al.   BIOMEDICINE & PHARMACOTHERAPY

Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components

(2019) Paolo Dolzani et al.   PLoS One

Early Alterations of Subchondral Bone in the Rat Anterior Cruciate Ligament Transection Model of Osteoarthritis

(2019) Nik Aizah et al.   Cartilage

Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes

(2019) Genlai Du et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Spatially confined induction of endochondral ossification by functionalized hydrogels for ectopic engineering of osteochondral tissues

(2018) Chiara Stüdle et al.   BIOMATERIALS

Mimicking the 3D biology of osteochondral tissue with microfluidic-based solutions: breakthroughs towards boosting drug testing and discovery

(2018) Mariana R. Carvalho et al.   DRUG DISCOVERY TODAY

Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice

(2018) Jiansen Lu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoarthritis as a disease of the cartilage pericellular matrix

(2018) Farshid Guilak et al.   MATRIX BIOLOGY

The pericellular hyaluronan of articular chondrocytes

(2018) Warren Knudson et al.   MATRIX BIOLOGY

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

(2018) Tokio Matsuzaki et al.   Science Translational Medicine

Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-Scale Gradient Hydrogels as 3D Cell Niche

(2018) Danqing Zhu et al.   TISSUE ENGINEERING PART A

Deformable 96-well cell culture plate compatible with high-throughput screening platforms

(2018) Tsubasa S. Matsui et al.   PLoS One

Effect of joint mimicking loading system on zonal organization into tissue-engineered cartilage

(2018) In-Su Park et al.   PLoS One

Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study

(2018) Elena Stavenschi et al.   Stem Cell Research & Therapy

Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway

(2017) Sara Cheleschi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microfluidic co-culture platform for investigating osteocyte-osteoclast signalling during fluid shear stress mechanostimulation

(2017) K. Middleton et al.   JOURNAL OF BIOMECHANICS

Mitochondrial dysfunction is an acute response of articular chondrocytes to mechanical injury

(2017) Michelle L. Delco et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Bone marrow-on-a-chip: Long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment

(2017) Stefan Sieber et al.   Journal of Tissue Engineering and Regenerative Medicine

Mechanical confinement regulates cartilage matrix formation by chondrocytes

(2017) Hong-pyo Lee et al.   NATURE MATERIALS

A novel bioreactor system for biaxial mechanical loading enhances the properties of tissue-engineered human cartilage

(2017) Christoph Meinert et al.   Scientific Reports

A comparative study of chondroitin sulfate and heparan sulfate for directing three-dimensional chondrogenesis of mesenchymal stem cells

(2017) Tianyi Wang et al.   Stem Cell Research & Therapy

Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor

(2017) Penelope M. Tsimbouri et al.   Nature Biomedical Engineering

The Distinct Effects of Estrogen and Hydrostatic Pressure on Mesenchymal Stem Cells Differentiation: Involvement of Estrogen Receptor Signaling

(2016) Ying Zhao et al.   ANNALS OF BIOMEDICAL ENGINEERING

Comparative effect of physicomechanical and biomolecular cues on zone-specific chondrogenic differentiation of mesenchymal stem cells

(2016) Seyedsina Moeinzadeh et al.   BIOMATERIALS

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology

(2016) T. Felka et al.   OSTEOARTHRITIS AND CARTILAGE

Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes

(2016) Z. He et al.   OSTEOARTHRITIS AND CARTILAGE

What drives osteoarthritis?—synovialversussubchondral bone pathology

(2016) Thomas Hügle et al.   RHEUMATOLOGY

Purinergic Signaling Regulates the Transforming Growth Factor-β3-Induced Chondrogenic Response of Mesenchymal Stem Cells to Hydrostatic Pressure

(2016) Andrew J. Steward et al.   TISSUE ENGINEERING PART A

In vitro models for the study of osteoarthritis

(2016) Craig I. Johnson et al.   VETERINARY JOURNAL

Injurious Loading of Articular Cartilage Compromises Chondrocyte Respiratory Function

(2016) Mitchell C. Coleman et al.   Arthritis & Rheumatology

Stretch Injury of Human Induced Pluripotent Stem Cell Derived Neurons in a 96 Well Format

(2016) Sydney A. Sherman et al.   Scientific Reports

Cyclic stretch enhances bone morphogenetic protein-2-induced osteoblastic differentiation through the inhibition of Hey1

(2015) ZHAOBIN ZENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hydrostatic Pressure Influences HIF-2 Alpha Expression in Chondrocytes

(2015) Hiroaki Inoue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Hydrostatic pressure promotes the proliferation and osteogenic/chondrogenic differentiation of mesenchymal stem cells: The roles of RhoA and Rac1

(2015) Yin-Hua Zhao et al.   Stem Cell Research

Direct Cell–Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis

(2015) Tommy S. de Windt et al.   TISSUE ENGINEERING PART A

On the predictive utility of animal models of osteoarthritis

(2015) Anne-Marie Malfait et al.   ARTHRITIS RESEARCH & THERAPY

The Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage

(2015) Pei-Pei Guan et al.   Scientific Reports

JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis

(2015) Heba M. Ismail et al.   Arthritis & Rheumatology

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes

(2015) Heba M. Ismail et al.   Arthritis & Rheumatology

Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage

(2015) Nicole A. Zelenski et al.   Arthritis & Rheumatology

Integrin α1β1 participates in chondrocyte transduction of osmotic stress

(2014) Christina L. Jablonski et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression

(2014) M. Siebelt et al.   BONE

Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways

(2014) Peter M. Govey et al.   JOURNAL OF BIOMECHANICS

The structure and function of the pericellular matrix of articular cartilage

(2014) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

The chondrocyte primary cilium

(2014) R. Ruhlen et al.   OSTEOARTHRITIS AND CARTILAGE

Connexin43 hemichannels mediate small molecule exchange between chondrocytes and matrix in biomechanically-stimulated temporomandibular joint cartilage

(2014) J. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis

(2014) Johannah Sanchez-Adams et al.   Current Rheumatology Reports

A New Method to Investigate How Mechanical Loading of Osteocytes Controls Osteoblasts

(2014) Marisol Vazquez et al.   Frontiers in Endocrinology

A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate

(2013) Peter A. Levett et al.   Acta Biomaterialia

The spatial organisation of joint surface chondrocytes: review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis

(2013) Wilhelm K Aicher et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitochondrial respiratory chain dysfunction modulates metalloproteases -1, -3 and -13 in human normal chondrocytes in culture

(2013) Berta Cillero-Pastor et al.   BMC MUSCULOSKELETAL DISORDERS

Periodic Mechanical Stress Stimulates the FAK Mitogenic Signal in Rat Chondrocytes Through ERK1/2 Activity

(2013) Wenwei Liang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures

(2013) Tamás Juhász et al.   CELLULAR SIGNALLING

Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix

(2013) Tonia L Vincent   CURRENT OPINION IN PHARMACOLOGY

The Osteocyte: An Endocrine Cell … and More

(2013) Sarah L. Dallas et al.   ENDOCRINE REVIEWS

Strain-induced Differentiation of Fetal Type II Epithelial Cells Is Mediated via the Integrin α6β1-ADAM17/Tumor Necrosis Factor-α-converting Enzyme (TACE) Signaling Pathway

(2013) Yulian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-traumatic osteoarthritis: from mouse models to clinical trials

(2013) Christopher B. Little et al.   Nature Reviews Rheumatology

Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage

(2013) R.E. Wilusz et al.   OSTEOARTHRITIS AND CARTILAGE

Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis

(2013) T. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Bone mineral density changes in the knee following anterior cruciate ligament rupture

(2013) B.L. van Meer et al.   OSTEOARTHRITIS AND CARTILAGE

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis

(2013) Y. Akasaki et al.   OSTEOARTHRITIS AND CARTILAGE

Apparent elastic modulus of ex vivo trabecular bovine bone increases with dynamic loading

(2013) Juan Vivanco et al.   PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

Shear stress modulates macrophage-induced urokinase plasminogen activator expression in human chondrocytes

(2013) Chih-Chang Yeh et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxia Enhances Chondrogenesis and Prevents Terminal Differentiation through PI3K/Akt/FoxO Dependent Anti-Apoptotic Effect

(2013) Hsieh-Hsing Lee et al.   Scientific Reports

Stem cells catalyze cartilage formation by neonatal articular chondrocytes in 3D biomimetic hydrogels

(2013) Janice H. Lai et al.   Scientific Reports

Cell–matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure

(2012) A.J. Steward et al.   Acta Biomaterialia

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Calcium response in osteocytic networks under steady and oscillatory fluid flow

(2012) X. Lucas Lu et al.   BONE

Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations

(2012) Oran D. Kennedy et al.   BONE

Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases

(2012) Judith Sylvester et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Phenotypic Characterization of Osteoarthritic Osteocytes from the Sclerotic Zones: A Possible Pathological Role in Subchondral Bone Sclerosis

(2012) Anjali Jaiprakash et al.   International Journal of Biological Sciences

Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance

(2012) Simon Y Tang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Differentiation of bone marrow-derived mesenchymal stem cells into chondrocytes using chondrocyte extract

(2012) XINJIE TANG et al.   Molecular Medicine Reports

Bone remodelling in osteoarthritis

(2012) David B. Burr et al.   Nature Reviews Rheumatology

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation

(2012) Sang-Hyug Park et al.   PLoS One

Primary Cilia-Mediated Mechanotransduction in Human Mesenchymal Stem Cells

(2012) David A. Hoey et al.   STEM CELLS

Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

(2012) Steven R. Goldring   Therapeutic Advances in Musculoskeletal Disease

Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: An in vivo microfocal computed tomography study

(2011) Sander M. Botter et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: Establishment and characterization of a long-term cartilage-synovium coculture

(2011) Michiel Beekhuizen et al.   ARTHRITIS AND RHEUMATISM

Engineering articular cartilage with spatially-varying matrix composition and mechanical properties from a single stem cell population using a multi-layered hydrogel

(2011) Lonnissa H. Nguyen et al.   BIOMATERIALS

Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints

(2011) Jun Pan et al.   BONE

Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1

(2011) Pu Wang et al.   FASEB JOURNAL

Effect of oscillating fluid flow stimulation on osteocyte mRNA expression

(2011) Jason Li et al.   JOURNAL OF BIOMECHANICS

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts

(2011) Thomas F. Chan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Interleukin-1α, -6, and -8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype

(2011) Kira D. Novakofski et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1–Ddr2–Mmp-13 degradative pathway: a new model of osteoarthritis

(2011) D.W. Holt et al.   OSTEOARTHRITIS AND CARTILAGE

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

Proliferative re-modeling of the spatial organization of human superficial chondrocytes distant to focal early osteoarthritis (OA)

(2010) Bernd Rolauffs et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritic chondrocyte-secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cells

(2010) Aereas Aung et al.   ARTHRITIS AND RHEUMATISM

β1 Integrins Mediate Mechanosensitive Signaling Pathways in Osteocytes

(2010) Julie B. Litzenberger et al.   CALCIFIED TISSUE INTERNATIONAL

Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system

(2010) Yu-Yu Lin et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Shear-induced Interleukin-6 Synthesis in Chondrocytes

(2010) Pu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loading of the knee joint during activities of daily living measured in vivo in five subjects

(2010) I. Kutzner et al.   JOURNAL OF BIOMECHANICS

Bone matrix RGD glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro

(2010) Wojciech J. Grzesik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of intermittent hydrostatic pressure and BMP-2 on osteoarthritic human chondrocyte metabolism in vitro

(2010) R.L. Smith et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Abnormal human chondrocyte morphology is related to increased levels of cell-associated IL-1β and disruption to pericellular collagen type VI

(2010) Dianne H. Murray et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis

(2010) Fei Zhu et al.   PLoS One

Cellular mechanisms of bone remodeling

(2010) Erik Fink Eriksen   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Influence of Shear Stress in Perfusion Bioreactor Cultures for the Development of Three-Dimensional Bone Tissue Constructs: A Review

(2010) Ryan J. McCoy et al.   TISSUE ENGINEERING PART B-REVIEWS

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

(2010) Miriam Bellido et al.   ARTHRITIS RESEARCH & THERAPY

Attachment of Osteocyte Cell Processes to the Bone Matrix

(2009) L.M. McNamara et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

(2009) Denis Couchourel et al.   ARTHRITIS AND RHEUMATISM

Regulation of plasminogen activator inhibitor 1 expression in human osteoarthritic chondrocytes by fluid shear stress: Role of protein kinase Cα

(2009) Chih-Chang Yeh et al.   ARTHRITIS AND RHEUMATISM

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density — Is there a role for mechanosensing?

(2009) Ruud P. van Hove et al.   BONE

Deletion of β1 Integrins from Cortical Osteocytes Reduces Load-Induced Bone Formation

(2009) Julie B. Litzenberger et al.   Cellular and Molecular Bioengineering

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium?

(2009) M. M. Knight et al.   JOURNAL OF ANATOMY

Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway

(2009) Mariana Garcia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Transcriptional Activity of Sox9 in Chondrocytes Is Regulated by RhoA Signaling and Actin Polymerization

(2009) D. Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels

(2009) G.D. Nicodemus et al.   OSTEOARTHRITIS AND CARTILAGE

Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling

(2009) Jin Nam et al.   PLoS One

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Temporal Effects of Impact on Articular Cartilage Cell Death, Gene Expression, Matrix Biochemistry, and Biomechanics

(2008) Roman M. Natoli et al.   ANNALS OF BIOMEDICAL ENGINEERING

Cell–cell communication in the osteoblast/osteocyte lineage

(2008) Roberto Civitelli   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Perlecan, the “jack of all trades” proteoglycan of cartilaginous weight-bearing connective tissues

(2008) James Melrose et al.   BIOESSAYS

Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited

(2008) Anna Teti et al.   BONE

Cyclic Hydraulic Pressure and Fluid Flow Differentially Modulate Cytoskeleton Re-Organization in MC3T3 Osteoblasts

(2008) Joseph D. Gardinier et al.   Cellular and Molecular Bioengineering

Influence of cortical canal architecture on lacunocanalicular pore pressure and fluid flow

(2008) G.C. Goulet et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Gap Junctions and Osteoblast-like Cell Gene Expression in Response to Fluid Flow

(2008) Michael G. Jekir   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

SOX9 Directly Binds CREB as a Novel Synergism With the PKA Pathway in BMP-2–Induced Osteochondrogenic Differentiation

(2008) Li Zhao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regional bone density changes in anterior cruciate ligament deficient knees: A DEXA study

(2008) Ahmet Bayar et al.   KNEE

Role of Bone in Osteoarthritis Pathogenesis

(2008) Steven R. Goldring   MEDICAL CLINICS OF NORTH AMERICA

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

(2008) R. G. G. Russell et al.   OSTEOPOROSIS INTERNATIONAL

Mechanical Stimulation of Osteoblasts Using Steady and Dynamic Fluid Flow

(2008) Michael J. Jaasma et al.   TISSUE ENGINEERING PART A

Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca2+- and ATP-dependent in MC3T3-E1 osteoblasts

(2007) Dawei Liu et al.   BONE

In vitro expansion affects the response of chondrocytes to mechanical stimulation

(2007) R.H.J. Das et al.   OSTEOARTHRITIS AND CARTILAGE