Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Chengyu Zhu, Haili Ding, Liang Shi, Shihua Zhang, Xiaoyang Tong, Mei Huang, Lifei Liu, Xiaotian Guan, Jun Zou, Yu Yuan, Xi Chen
Summary: This study aimed to investigate the impact of running exercise on bone health in aging mice and explore the role of SIRT1 in controlling autophagy and osteogenic differentiation of BMSCs. The results showed that aging mice had lower bone mass, BMD, and autophagy compared to young mice, while running exercise improved BMD and bone mass and increased autophagy in bone cells. Mechanical loading enhanced osteogenic differentiation and autophagy in BMSCs, and the knockdown of SIRT1 in BMSCs demonstrated that SIRT1-mediated autophagy was involved in the activation of osteogenic differentiation by mechanical loading.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Ho-Ying Wan, Rita Lih Ying Shin, Jack Chun Hin Chen, Marisa Assuncao, Dan Wang, Susie K. Nilsson, Rocky S. Tuan, Anna Blocki
Summary: The study demonstrated that supplementation of Dextran sulfate (DxS) in osteogenically induced cultures of human mesenchymal stem cells (MSCs) amplified the deposition of osteoblastic extracellular matrix (ECM). This enhancement led to increased collagen type I deposition and osteogenic gene expression, as well as enrichment in bone morphogenetic protein 2 (BMP-2), suggesting a potential role of DxS in promoting osteogenic differentiation by MSCs.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Renhao Sun, Chunxi Zhang, Yicong Liu, Zhenggang Chen, Wen Liu, Fang Yang, Fei Zeng, Qingyuan Guo
Summary: This study investigated the effects of demethyltransferase FTO on osteogenic differentiation of BMSCs under mechanical stress condition. The results showed that FTO promoted the expression of HIF-1α and osteogenic differentiation in BMSCs under mechanical stress.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee
Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Eugene Lee, Ju-young Kim, Tae-Kyung Kim, Seo-Young Park, Gun-Il Im
Summary: Research suggests that overexpression of the novel factor METTL7A enhances osteogenic differentiation and viability of hBMSCs by regulating the methylation status of genes related to osteogenesis or survival, ultimately improving the effectiveness of stem cell transplantation in large bone defects.
CELL DEATH DISCOVERY
(2021)
Article
Engineering, Biomedical
Man Zhang, Qian Sun, Yiling Liu, Zhiqin Chu, Leixiao Yu, Yong Hou, Heemin Kang, Qiang Wei, Weifeng Zhao, Joachim P. Spatz, Changsheng Zhao, Elisabetta A. Cavalcanti-Adam
Summary: Tunable mechanical properties of hydrogels play a key role in regulating stem cell differentiation. By modulating cellular spatial sensing of integrin-adhesive ligands on low stiffness hydrogels, the mechanosensing and osteogenic differentiation of MSCs can be promoted to levels comparable with those observed on stiffer hydrogels. This approach opens up new possibilities for designing biomaterials and tissue scaffolds for regenerative therapeutics.
Article
Cell Biology
Guozheng Zhu, Canjun Zeng, Yuepeng Qian, Song Yuan, Zelin Ye, Shanwen Zhao, Runguang Li
Summary: The study found that appropriate tensile strain can promote osteogenic differentiation of BMSCs while inhibiting adipogenic differentiation, simultaneously promoting the expression of lncRNA-MEG3. Overexpression of lncRNA-MEG3 further enhances osteogenic differentiation of stressed BMSCs and inhibits the expression of miR-140-5p, while silencing lncRNA-MEG3 produces opposite effects.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chiara Mazziotta, Carmen Lanzillotti, Maria Rosa Iaquinta, Francesca Taraballi, Elena Torreggiani, John Charles Rotondo, Lucia Oton-Gonzalez, Elisa Mazzoni, Francesca Frontini, Ilaria Bononi, Monica De Mattei, Mauro Tognon, Fernanda Martini
Summary: MSCs are important source for bone regeneration and play a crucial role in osteogenic differentiation. MiRNAs regulate gene expression in osteogenic differentiation of MSCs and are involved in controlling important signaling pathways such as TGF-beta/BMP and Wnt/beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Mingjun Li, Xiangwen Shi, Yipeng Wu, Baochuang Qi, Chaoqun Zhang, Bin Wang, Bihuan Zhang, Yongqing Xu
Summary: This study explores the mechanisms of BMSCs injury and osteogenic differentiation inhibition in osteomyelitis, and identifies a potential therapeutic target. The results show that knocking down the Pmepa1 gene can alleviate infection-induced cell injury and promote osteoblast differentiation. The findings are supported by results from a rat model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Orthopedics
He Lin, Lanjun Nie, Guiqing Lu, Haixia Wu, Tao Xu
Summary: This study demonstrated that upregulation of KCNQ10T1 promoted osteogenic differentiation of BMSCs through the miR-19a-3p/SMAD5 axis, providing a novel mechanism and potential therapeutic target for fracture healing.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Ruyin Lyu, Yuping Chen, Yajun Shuai, Jie Wang, Leihao Lu, Qichao Cheng, Jiangfeng Cai, Chuanbin Mao, Mingying Yang
Summary: We demonstrate a universal strategy for discovering peptides that can bind to and functionalize biomaterials using a Bombyx mori silk fibroin membrane as a model. By fusing two peptides, one screened for binding to the biomaterial and another derived from a growth factor, a new chimeric peptide is created to efficiently bind to the silk fibroin membrane. The chimeric peptide enables the membrane to induce osteogenic differentiation of human mesenchymal stem cells and stimulate bone regeneration in a rat model without causing inflammation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Paulina Kazimierczak, Malgorzata Koziol, Agata Przekora
Summary: The newly developed biomaterial showed high biocompatibility and influenced macrophage polarization and osteoblast differentiation, playing an immunomodulatory role. The study demonstrated a low risk of inflammatory response and induced macrophage polarization into the osteogenic phenotype M2, making it a promising bone scaffold for regenerative medicine applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Keya Ganguly, Sayan Deb Dutta, Min-Soo Jeong, Dinesh K. Patel, Seong-Jun Cho, Ki-Taek Lim
Summary: Proteins extracted from crickets exhibit good biocompatibility and osteoinductive potential, making them valuable for bone tissue engineering applications.
Article
Biology
Zhaoyi Mai, Jingpeng Liu, Xiao Jiang, Wenli Gu, Wei Wang, Simin Li, Gerhard Schmalz, Hui Xiao, Jianjiang Zhao
Summary: This study reports for the first time that the lncRNA KCNMA1-AS1 plays a vital role in regulating the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). KCNMA1-AS1 overexpression enhances in vitro osteogenic differentiation and in vivo bone formation, while knockdown of KCNMA1-AS1 has the opposite effect. Furthermore, the interaction between KCNMA1-AS1 and SMAD9 regulates the activation of the SMAD9 signaling pathway.
Review
Pharmacology & Pharmacy
Xuchang Zhou, Hong Cao, Jianming Guo, Yu Yuan, Guoxin Ni
Summary: Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells. EVs, especially BMSC-EVs, have therapeutic effects such as tissue repair, inhibition of macrophage polarization, and promotion of angiogenesis. BMSC-EVs also serve as efficient nanocarriers for drug delivery with advantages such as low immunogenicity, no ethical controversy, good stability, and easy storage.
Review
Biotechnology & Applied Microbiology
Hao-Nan Wang, Xiao Rong, Lu-Ming Yang, Wei-Zhong Hua, Guo-Xin Ni
Summary: This review summarizes the advances of stem cells and stem cell-derived extracellular vesicles (EVs) in the repair of rotator cuff injuries, highlighting the underlying mechanisms and suggesting future directions for research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Neurosciences
Yue Xu, Wanxia Zhang, Hanfeng Zhang, Lijuan Wang, Yanlin Luo, Guoxin Ni
Summary: This study found that children who had undergone long-term tennis training performed better in cognitive flexibility and working memory compared to those who had undergone short-term training. This suggests a positive association between tennis experience and executive functions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Yue Xu, Wanxia Zhang, Kexin Zhang, Min Feng, Tianqi Duan, Yilin Chen, Xuexiang Wei, Yanlin Luo, Guoxin Ni
Summary: This study investigates the relationship between the frequency of basketball training and executive functions in boys aged 6 to 8. The findings suggest that regular basketball training, especially with higher frequency, is beneficial to working memory and cognitive flexibility in this age group.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Yihui Cai, Zi Wang, Wanxia Zhang, Weiya Kong, Jiayao Jiang, Ruobing Zhao, Dongxue Wang, Leyi Feng, Guoxin Ni
Summary: The study examined the reliability and validity of the Lexin Mio smart bracelet in measuring heart rate and energy expenditure in individuals with different physical activity levels and exercising at various intensities. The results indicated that the smart bracelet showed good reliability and validity for heart rate measurement, but poor validity for energy expenditure measurement.
Article
Neurosciences
Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Guo-Xin Ni
Summary: Electrophysiological recording can be used to quantify the clinical features and lesion location in patients with central poststroke pain (CPSP). This study found that CPSP patients with thalamic lesions and internal capsule lesions differed in terms of abnormal fiber types, sensory dysfunction territory, and clinical signs.
Editorial Material
Neurosciences
Guo-Xin Ni, Gao-Xia Wei, Xiang-Ping Chu, Anke Ninjia Karabanov
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Physiology
Yue Xu, Bin Song, Anghan Ming, Congda Zhang, Guoxin Ni
Summary: Chronic ankle instability (CAI) causes biomechanical changes in the lower extremity, affecting not only the ankle joint but also the proximal joints and increasing the risk of joint injury. This systematic review examined the research on CAI and lower extremity angle and movements during side-cutting, stop jumping, and landing tasks. The findings suggest that participants with CAI exhibit altered lower extremity proximal joint movement strategies during these tasks, potentially increasing the risk of anterior cruciate ligament injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Lu Gao, Weizhong Hua, Lixiang Tian, Xuchang Zhou, Dongxue Wang, Yajing Yang, Guoxin Ni
Summary: This article reviews the mechanism of ferroptosis in bone-related diseases and explores its regulatory targets, which may provide a new approach for the prevention and treatment of orthopedic diseases.
Article
Clinical Neurology
Arif Sikandar, Xia-Hua Liu, Hao-Ling Xu, Ying Li, Yun-Qing Lin, Xin-Yuan Chen, Gui-He Li, Min-Ting Lin, Ning Wang, Wan-Jin Chen, Guo-Xin Ni, Shi-Rui Gan
Summary: This study found that treatment with repetitive transcranial magnetic stimulation (rTMS) over the cerebellum for 15 consecutive days improved ataxia symptoms in patients with spinocerebellar ataxia type 3 (SCA3). Compared to the sham group, the real stimulation group showed significantly larger improvements in ataxia scores. These results suggest that rTMS may be a promising tool for rehabilitative approaches in SCA3.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Multidisciplinary Sciences
Grant Broussard, Guoxin Ni, Zhigang Zhang, Qian Li, Patricio Cano, Dirk P. Dittmer, Blossom Damania
Summary: This study reveals that the barrier-to-autointegration factor 1 (BAF) is necessary for the reactivation of Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) by suppressing the cGAS-STING signaling pathway. BAF destabilizes cGAS expression, leading to increased antiviral responses and decreased viral replication. BAF could be a potential target for treating viral infections and malignancies.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Huirong Zhang, Jason P. Wong, Guoxin Ni, Patricio Cano, Dirk P. Dittmer, Blossom Damania
Summary: The study identified a cellular factor called TBRG4 that regulates the lytic reactivation of KSHV and EBV by controlling the production of reactive oxygen species (ROS). Knockdown of TBRG4 induced viral lytic gene transcription and replication in cells latently infected with KSHV or EBV. This research provides insights into the molecular mechanism of gammaherpesvirus reactivation and suggests TBRG4 as a potential therapeutic target for virus-associated malignancies.
Letter
Engineering, Biomedical
Yongbin He, Haifeng Tang, Dongxue Wang, Shuqin Gu, Guoxin Ni, Haiyang Wu
Summary: The study explores the potential role of ChatGPT/GPT-4 in various aspects of spinal surgical practice, particularly in the perioperative management of endoscopic spinal surgery for patients with lumbar disc herniation. The AI-driven chatbot can improve communication, data collection, surgical planning, and provide intraoperative support and postoperative rehabilitation guidance. However, the appropriate use of ChatGPT/GPT-4, considering data security and privacy risks, is crucial. The study concludes that ChatGPT/GPT-4 can be a valuable tool for spinal surgeons if used correctly and responsibly.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Editorial Material
Public, Environmental & Occupational Health
Ziru Wang, Wendy Yajun Huang, Youcheng Liu, Guoxin Ni
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Endocrinology & Metabolism
Ruobing Zhao, Yan Chen, Dongxue Wang, Chunyu Zhang, Henan Song, Guoxin Ni
Summary: Bone diseases are common and detrimental to the daily activities and quality of life of middle-aged and elderly individuals. It is essential to identify key regulatory factors and potential therapeutic targets for bone diseases. Irisin, a newly discovered myokine, has been found to have beneficial effects on various diseases, especially bone-related disorders. Research has indicated that irisin plays a role in bone diseases such as osteoarthritis and osteoporosis, suggesting its potential as a molecule for the prevention and treatment of bone diseases. This review summarizes the specific regulatory mechanisms of irisin in different bone diseases and provides a theoretical basis for its application in the diagnosis and treatment of these conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)