How cells respond to environmental cues – insights from bio-functionalized substrates

Plasticity of Cell Migration In Vivo and In Silico

(2016) Veronika te Boekhorst et al.   Annual Review of Cell and Developmental Biology

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

β3 integrin–mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner

(2016) Laure Fourel et al.   JOURNAL OF CELL BIOLOGY

Lamellipodia are crucial for haptotactic sensing and response

(2016) Samantha J. King et al.   JOURNAL OF CELL SCIENCE

Mechanical confinement triggers glioma linear migration dependent on formin FHOD3

(2016) Pascale Monzo et al.   MOLECULAR BIOLOGY OF THE CELL

α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

(2016) Giovanni Meacci et al.   MOLECULAR BIOLOGY OF THE CELL

Cooperative Vinculin Binding to Talin Mapped by Time-Resolved Super Resolution Microscopy

(2016) Xian Hu et al.   NANO LETTERS

Extracellular matrix scaffolding guides lumen elongation by inducing anisotropic intercellular mechanical tension

(2016) Qiushi Li et al.   NATURE CELL BIOLOGY

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

(2016) Sophie V. Pageon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

Still and rotating myosin clusters determine cytokinetic ring constriction

(2016) Viktoria Wollrab et al.   Nature Communications

Modeling cell shape and dynamics on micropatterns

(2016) Philipp J. Albert et al.   Cell Adhesion & Migration

Multiprotein Printing by Light-Induced Molecular Adsorption

(2015) Pierre-Olivier Strale et al.   ADVANCED MATERIALS

Micropatterning strategies to engineer controlled cell and tissue architecture in vitro

(2015) Elisa D'Arcangelo et al.   BIOTECHNIQUES

Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility

(2015) Verena Ruprecht et al.   CELL

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence

(2015) Paolo Maiuri et al.   CELL

Mammary gland development: cell fate specification, stem cells and the microenvironment

(2015) J. L. Inman et al.   DEVELOPMENT

Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions

(2015) Yao Wu et al.   DEVELOPMENTAL CELL

Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins

(2015) Marc Renz et al.   DEVELOPMENTAL CELL

The formation of ordered nanoclusters controls cadherin anchoring to actin and cell–cell contact fluidity

(2015) Pierre-Olivier Strale et al.   JOURNAL OF CELL BIOLOGY

Protrusive waves guide 3D cell migration along nanofibers

(2015) Charlotte Guetta-Terrier et al.   JOURNAL OF CELL BIOLOGY

Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis

(2015) Nduka O. Enemchukwu et al.   JOURNAL OF CELL BIOLOGY

Spatial distribution of cell–cell and cell–ECM adhesions regulates force balance while main­taining E-cadherin molecular tension in cell pairs

(2015) Joo Yong Sim et al.   MOLECULAR BIOLOGY OF THE CELL

Receptor clustering control and associated force sensing by surface patterning: when force matters

(2015) Elisabetta Ada Cavalcanti-Adam et al.   Nanomedicine

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells

(2015) Pablo Vargas et al.   NATURE CELL BIOLOGY

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

(2015) Haguy Wolfenson et al.   NATURE CELL BIOLOGY

Force transmission during adhesion-independent migration

(2015) Martin Bergert et al.   NATURE CELL BIOLOGY

A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels

(2015) Cole A. DeForest et al.   NATURE MATERIALS

3D high- and super-resolution imaging using single-objective SPIM

(2015) Remi Galland et al.   NATURE METHODS

Nuclear deformability and telomere dynamics are regulated by cell geometric constraints

(2015) Ekta Makhija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin junction formation involves an active kinetic nucleation process

(2015) Kabir H. Biswas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model-based Traction Force Microscopy Reveals Differential Tension in Cellular Actin Bundles

(2015) Jérôme R. D. Soiné et al.   PLoS Computational Biology

Control of stem cell fate by engineering their micro and nanoenvironment

(2015) Michelle F Griffin   World Journal of Stem Cells

Recapitulating Cell–Cell Adhesion Using N-Cadherin Biologically Tethered to Substrates

(2014) Johana C. M. Vega L. et al.   BIOMACROMOLECULES

Geometry Regulates Traction Stresses in Adherent Cells

(2014) Patrick W. Oakes et al.   BIOPHYSICAL JOURNAL

Spatial Organization of EphA2 at the Cell-Cell Interface Modulates Trans-Endocytosis of EphrinA1

(2014) Adrienne C. Greene et al.   BIOPHYSICAL JOURNAL

Force Measurement Tools to Explore Cadherin Mechanotransduction

(2014) Sarah C. Stapleton et al.   CELL COMMUNICATION AND ADHESION

Adhesive interactions of N-cadherin limit the recruitment of microtubules to cell-cell contacts through organization of actomyosin

(2014) C. Plestant et al.   JOURNAL OF CELL SCIENCE

A review of non-contact micro- and nano-printing technologies

(2014) Changhai Ru et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of Integrin Clustering on Force Transmission

(2014) Yang Liu et al.   NANO LETTERS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions

(2014) W. Engl et al.   NATURE CELL BIOLOGY

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Materials as stem cell regulators

(2014) William L. Murphy et al.   NATURE MATERIALS

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physical influences of the extracellular environment on cell migration

(2014) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

Emergence of collective modes and tri-dimensional structures from epithelial confinement

(2014) M. Deforet et al.   Nature Communications

A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells

(2014) Alireza Dolatshahi-Pirouz et al.   Scientific Reports

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Engineering Biomolecular Microenvironments for Cell Instructive Biomaterials

(2014) Catarina A. Custódio et al.   Advanced Healthcare Materials

Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters

(2014) Mei Rosa Ng et al.   eLife

Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through αvβ3- or α5β1-Integrins

(2013) Sabri Rahmouni et al.   ADVANCED MATERIALS

The regulation of dynamic mechanical coupling between actin cytoskeleton and nucleus by matrix geometry

(2013) Qingsen Li et al.   BIOMATERIALS

Guidance of Cell Migration by Substrate Dimension

(2013) Stephanie S. Chang et al.   BIOPHYSICAL JOURNAL

Principles of E-Cadherin Supramolecular Organization In Vivo

(2013) Binh-An Truong Quang et al.   CURRENT BIOLOGY

Guidance of collective cell migration by substrate geometry

(2013) Kevin Doxzen et al.   Integrative Biology

Investigating Axonal Guidance with Microdevice-Based Approaches

(2013) I. Dupin et al.   JOURNAL OF NEUROSCIENCE

Engineering microfluidic concentration gradient generators for biological applications

(2013) Alicia G. G. Toh et al.   Microfluidics and Nanofluidics

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Collective Cell Migration: A Mechanistic Perspective

(2013) Sri Ram Krishna Vedula et al.   PHYSIOLOGY

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces

(2013) A. F. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward 3D Biomimetic Models to Understand the Behavior of Glioblastoma Multiforme Cells

(2013) Shreyas S. Rao et al.   TISSUE ENGINEERING PART B-REVIEWS

Mechanisms of leading edge protrusion in interstitial migration

(2013) Kerry Wilson et al.   Nature Communications

Receptor Signaling Clusters in the Immune Synapse

(2012) Michael L. Dustin et al.   Annual Review of Biophysics

Engineering microscale topographies to control the cell–substrate interface

(2012) Mehdi Nikkhah et al.   BIOMATERIALS

The first World Cell Race

(2012) Paolo Maiuri et al.   CURRENT BIOLOGY

Fellow travellers: emergent properties of collective cell migration

(2012) Pernille Rørth   EMBO REPORTS

The study of polarisation in single cells using model cell membranes

(2012) Mirren Charnley et al.   Integrative Biology

Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis

(2012) Alejo E. Rodríguez-Fraticelli et al.   JOURNAL OF CELL BIOLOGY

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

Matrix nanotopography as a regulator of cell function

(2012) Deok-Ho Kim et al.   JOURNAL OF CELL BIOLOGY

Nonpolarized signaling reveals two distinct modes of 3D cell migration

(2012) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

Reprogramming cell shape with laser nano-patterning

(2012) T. Vignaud et al.   JOURNAL OF CELL SCIENCE

Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension

(2012) S. R. Coyer et al.   JOURNAL OF CELL SCIENCE

Micro-environmental control of cell migration - myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics

(2012) A. D. Doyle et al.   JOURNAL OF CELL SCIENCE

A three-component mechanism for fibroblast migration with a contractile cell body that couples a myosin II–independent propulsive anterior to a myosin II–dependent resistive tail

(2012) Wei-hui Guo et al.   MOLECULAR BIOLOGY OF THE CELL

In vitro cell migration and invasion assays

(2012) Nina Kramer et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

An integrin–ILK–microtubule network orients cell polarity and lumen formation in glandular epithelium

(2012) Nasreen Akhtar et al.   NATURE CELL BIOLOGY

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Mechanical waves during tissue expansion

(2012) Xavier Serra-Picamal et al.   Nature Physics

High-Content Neurite Development Study Using Optically Patterned Substrates

(2012) Jonathan M. Bélisle et al.   PLoS One

Easy Fabrication of Thin Membranes with Through Holes. Application to Protein Patterning

(2012) Thomas Masters et al.   PLoS One

Spatial organization of the extracellular matrix regulates cell-cell junction positioning

(2012) Q. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cells test substrate rigidity by local contractions on submicrometer pillars

(2012) S. Ghassemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coherent angular motion in the establishment of multicellular architecture of glandular tissues

(2012) K. Tanner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis

(2012) Nathan E. Reticker-Flynn et al.   Nature Communications

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

(2012) Marie Versaevel et al.   Nature Communications

Presentation of BMP-2 from a Soft Biopolymeric Film Unveils its Activity on Cell Adhesion and Migration

(2011) Thomas Crouzier et al.   ADVANCED MATERIALS

Two-Component Polymer Scaffolds for Controlled Three-Dimensional Cell Culture

(2011) Franziska Klein et al.   ADVANCED MATERIALS

Switchable adhesive substrates: Revealing geometry dependence in collective cell behavior

(2011) Claudio G. Rolli et al.   BIOMATERIALS

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation

(2011) C.-h. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-ECM traction force modulates endogenous tension at cell-cell contacts

(2011) V. Maruthamuthu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strategies for Patterning Biomolecules with Dip-Pen Nanolithography

(2011) Chien-Ching Wu et al.   Small

Physical Aspects of Cell Culture Substrates: Topography, Roughness, and Elasticity

(2011) Aftin M. Ross et al.   Small

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro

(2010) Jennifer L. Young et al.   BIOMATERIALS

Strength Dependence of Cadherin-Mediated Adhesions

(2010) Benoit Ladoux et al.   BIOPHYSICAL JOURNAL

Biomimetic gradient hydrogels for tissue engineering

(2010) Shilpa Sant et al.   CANADIAN JOURNAL OF CHEMICAL ENGINEERING

Microfluidic gradient platforms for controlling cellular behavior

(2010) Bong Geun Chung et al.   ELECTROPHORESIS

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

(2010) K. Lee et al.   Journal of the Royal Society Interface

Engineering supported membranes for cell biology

(2010) Cheng-han Yu et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography

(2010) Israel Patla et al.   NATURE CELL BIOLOGY

Cell Migration Driven by Cooperative Substrate Deformation Patterns

(2010) Thomas E. Angelini et al.   PHYSICAL REVIEW LETTERS

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions

(2010) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function

(2009) Christopher J. Bettinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Materials in the Study of Cell Response to Substrate Rigidity

(2009) Stephanie Nemir et al.   ANNALS OF BIOMEDICAL ENGINEERING

Spontaneous migration of cancer cells under conditions of mechanical confinement

(2009) Daniel Irimia et al.   Integrative Biology

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Simple and rapid process for single cell micro-patterning

(2009) Ammar Azioune et al.   LAB ON A CHIP

Rapid multicomponent optical protein patterning

(2009) Jonathan M. Bélisle et al.   LAB ON A CHIP

Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion

(2009) Jinghuan Huang et al.   NANO LETTERS

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Quantitative Analysis of Complex Glioma Cell Migration on Electrospun Polycaprolactone Using Time-Lapse Microscopy

(2009) Jed Johnson et al.   TISSUE ENGINEERING PART C-METHODS

Molecular Bases of Cell-Cell Junctions Stability and Dynamics

(2009) M. Cavey et al.   Cold Spring Harbor Perspectives in Biology

Cooperativity in Adhesion Cluster Formation during Initial Cell Adhesion

(2008) Christine Selhuber-Unkel et al.   BIOPHYSICAL JOURNAL

Cell adaptive response to extracellular matrix density is controlled by ICAP-1–dependent β1-integrin affinity

(2008) Angélique Millon-Frémillon et al.   JOURNAL OF CELL BIOLOGY

Traction forces and rigidity sensing regulate cell functions

(2008) Marion Ghibaudo et al.   Soft Matter