Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation

Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule Level

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Using patterned supported lipid membranes to investigate the role of receptor organization in intercellular signaling

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Balancing forces: architectural control of mechanotransduction

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Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

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Force generated by actomyosin contraction builds bridges between adhesive contacts

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Recreation of the terminal events in physiological integrin activation

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Engineering supported membranes for cell biology

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Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Reducing background fluorescence reveals adhesions in 3D matrices

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Altered Actin Centripetal Retrograde Flow in Physically Restricted Immunological Synapses

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Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

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Integrins in immunity

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The Tail of Integrins, Talin, and Kindlins

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Stretching Single Talin Rod Molecules Activates Vinculin Binding

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The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

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Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Induction of Cell Polarization and Migration by a Gradient of Nanoscale Variations in Adhesive Ligand Spacing

(2008) Marco Arnold et al.   NANO LETTERS

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapid signal transduction in living cells is a unique feature of mechanotransduction

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