Receptor Signaling Clusters in the Immune Synapse

T Cell-Dendritic Cell Immunological Synapses Contain TCR-dependent CD28-CD80 Clusters That Recruit Protein Kinase C 

(2014) S.-Y. Tseng et al.   JOURNAL OF IMMUNOLOGY

EphA2 Receptor Activation by Monomeric Ephrin-A1 on Supported Membranes

(2011) Qian Xu et al.   BIOPHYSICAL JOURNAL

Signaling clusters in the cell membrane

(2011) Niña C Hartman et al.   CURRENT OPINION IN CELL BIOLOGY

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

(2011) B. N. Manz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling microdomains in T cells

(2010) Kaushik Choudhuri et al.   FEBS LETTERS

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Spatial organization and signal transduction at intercellular junctions

(2010) Boryana N. Manz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Altered Actin Centripetal Retrograde Flow in Physically Restricted Immunological Synapses

(2010) Cheng-han Yu et al.   PLoS One

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

The Cellular Context of T Cell Signaling

(2009) Michael L. Dustin   IMMUNITY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

T cell antigen receptor signaling and immunological synapse stability require myosin IIA

(2009) Tal Ilani et al.   NATURE IMMUNOLOGY

Cluster size regulates protein sorting in the immunological synapse

(2009) N. C. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC

(2009) L. J. Carreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Receptor Microcluster Transport through Molecular Mazes Reveals Mechanism of Translocation

(2008) Andrew L. DeMond et al.   BIOPHYSICAL JOURNAL

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY

T-cell activation through immunological synapses and kinapses

(2008) Michael L. Dustin   IMMUNOLOGICAL REVIEWS

Kinetic Control of Histidine-Tagged Protein Surface Density on Supported Lipid Bilayers

(2008) Jeffrey A. Nye et al.   LANGMUIR

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY