Cross-Talk between Wnt Signaling and Src Tyrosine Kinase

Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis

(2022) Núria Martínez-Gil et al.   Genes

Signaling Pathways Involved in 5-FU Drug Resistance in Cancer

(2022) Fahima Danesh Pouya et al.   CANCER INVESTIGATION

Wnt antagonist as therapeutic targets in ovarian cancer

(2022) Krithicaa Narayanaa Y. et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis

(2021) Andrew Blauvelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration

(2021) Oriane Guillermin et al.   EMBO JOURNAL

BOP1 confers chemoresistance of triple‐negative breast cancer by promoting CBP ‐mediated β‐catenin acetylation

(2021) Siqi Li et al.   JOURNAL OF PATHOLOGY

Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway

(2021) Karmani Shah et al.   PHARMACOLOGICAL RESEARCH

Recent updates on Wnt signaling modulators: a patent review (2014-2020)

(2021) Vishalgiri G. Goswami et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Wnt Pathway Modulators in Cancer Therapeutics‐ An Update on Completed and Ongoing Clinical Trials

(2021) Ann Neiheisel et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibiting Wnt/beta‐catenin in CTNNB1 ‐mutated endometrial cancer

(2021) Marisa R. Moroney et al.   MOLECULAR CARCINOGENESIS

Regulation of Wnt Signaling by FOX Transcription Factors in Cancer

(2021) Stefan Koch   Cancers

Ubiquitination of Src promotes its secretion via small extracellular vesicles

(2020) Kentaro Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis

(2020) Marwa Asem et al.   CANCER RESEARCH

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled

(2020) Marie-Claire Kratzer et al.   DEVELOPMENT

Nuclear Functions of the Tyrosine Kinase Src

(2020) Giulia Bagnato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway

(2020) Xiaohe Li et al.   Frontiers in Pharmacology

Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells

(2020) Eric Flores-Hernández et al.   CELLULAR SIGNALLING

Phase 1b study of Wnt inhibitor ipafricept (IPA) with gemcitabine and nab-paclitaxel in patients with previously untreated stage IV pancreatic cancer (mPDAC).

(2020) Efrat Dotan et al.   CLINICAL CANCER RESEARCH

Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation

(2020) Christin C. Anthony et al.   Genes

Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis

(2020) Takashi Matozaki et al.   CANCER SCIENCE

Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis

(2020) Loredana Moro et al.   NATURE CELL BIOLOGY

Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition

(2020) Juan Wang et al.   ONCOGENE

ROR2 blockade as a therapy for osteoarthritis

(2020) Anne-Sophie Thorup et al.   Science Translational Medicine

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

(2020) Shreyasi Mukherjee et al.   eLife

WNT/β-catenin signaling in the development of liver cancers

(2020) Shuai He et al.   BIOMEDICINE & PHARMACOTHERAPY

The tumor suppressor LATS2 reduces v‐Src‐induced membrane blebs in a kinase activity‐independent manner

(2020) Masayoshi Ikeuchi et al.   FASEB JOURNAL

Connexin43 Region 266–283, via Src Inhibition, Reduces Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and Increases Astrocytic Differentiation

(2020) Rocío Talaverón et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the Wnt/β-catenin signaling pathway in cancer

(2020) Ya Zhang et al.   Journal of Hematology & Oncology

Trifluridine/tipiracil plus bevacizumab as a first‐line treatment for elderly patients with metastatic colorectal cancer (KSCC1602): A multicenter phase II trial

(2020) Eiji Oki et al.   Cancer Medicine

Frizzled Receptors in Tumors, Focusing on Signaling, Roles, Modulation Mechanisms, and Targeted Therapies

(2020) Yu Sun et al.   ONCOLOGY RESEARCH

RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A

(2020) Jae-Gyu Kim et al.   Redox Biology

Wnt5a induces ROR1 and ROR2 to activate RhoA in esophageal squamous cell carcinoma cells

(2019) Xuping Wu et al.   Cancer Management and Research

Src and Fyn define a new signaling cascade activated by canonical and non-canonical Wnt ligands and required for gene transcription and cell invasion

(2019) Aida Villarroel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease

(2019) Christopher H. van Dyck et al.   JAMA Neurology

The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models

(2019) Betty Y. Tam et al.   CANCER LETTERS

Low Dose of Paclitaxel Combined with XAV939 Attenuates Metastasis, Angiogenesis and Growth in Breast Cancer by Suppressing Wnt Signaling

(2019) Dattatrya Shetti et al.   Cells

Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells

(2019) Marie-Ange Djeungoue-Petga et al.   Cell Death & Disease

Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia

(2018) Md Kamrul Hasan et al.   BLOOD

Acetylation within the N- and C-Terminal Domains of Src Regulates Distinct Roles of STAT3-Mediated Tumorigenesis

(2018) Chao Huang et al.   CANCER RESEARCH

Dual Src and MEK inhibition decreases ovarian cancer growth and targets tumor initiating stem-like cells

(2018) Fiona Simpkins et al.   CLINICAL CANCER RESEARCH

RAPGEF5 Regulates Nuclear Translocation of β-Catenin

(2018) John N. Griffin et al.   DEVELOPMENTAL CELL

Connexin43 Carboxyl-Terminal Domain Directly Interacts with β-Catenin

(2018) Gaelle Spagnol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity

(2018) Charlène Gayrard et al.   JOURNAL OF CELL BIOLOGY

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

(2018) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

A novel porcupine inhibitor blocks WNT pathways and attenuates cardiac hypertrophy

(2018) Jiahui Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes

(2018) Nikolaos Doumpas et al.   EMBO JOURNAL

Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling

(2018) Linh T. Vuong et al.   Nature Communications

Src nuclear localization and its prognostic relevance in human osteosarcoma

(2017) Enrica Urciuoli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)

(2017) Jacob Schachter et al.   LANCET

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

(2017) Kelley S. Yan et al.   NATURE

Daam1 activates RhoA to regulate Wnt5a‑induced glioblastoma cell invasion

(2017) Guiyang Liu et al.   ONCOLOGY REPORTS

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling

(2017) Shunsuke Uehara et al.   Science Signaling

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling

(2017) Shunsuke Uehara et al.   Science Signaling

Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage

(2017) G Corda et al.   Oncogenesis

Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation

(2017) Jing Wang et al.   NEOPLASIA

Dasatinib: A Review in Chronic Myeloid Leukaemia and Ph+ Acute Lymphoblastic Leukaemia

(2016) Gillian M. Keating   DRUGS

Wnt‐induced deubiquitination FoxM1 ensures nucleus β‐catenin transactivation

(2016) Yaohui Chen et al.   EMBO JOURNAL

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1

(2016) Weidong Jin et al.   ONCOLOGY REPORTS

Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes

(2016) Ana González-Sánchez et al.   Oncotarget

The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells

(2016) Reem T. Attia et al.   PeerJ

Glycogen synthase kinase 3 in Wnt signaling pathway and cancer

(2015) Nydia Tejeda-Muñoz et al.   IUBMB LIFE

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease

(2015) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo

(2015) Anna Goc et al.   Oncotarget

Bosutinib efficacy and safety in chronic phase chronic myeloid leukemia after imatinib resistance or intolerance: Minimum 24-month follow-up

(2014) Carlo Gambacorti-Passerini et al.   AMERICAN JOURNAL OF HEMATOLOGY

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/ -catenin signalling

(2014) Q. Chen et al.   EMBO REPORTS

O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41

(2014) Stéphanie Olivier-Van Stichelen et al.   FASEB JOURNAL

Hsp27 regulates EGF/β-catenin mediated epithelial to mesenchymal transition in prostate cancer

(2014) Thomas Cordonnier et al.   INTERNATIONAL JOURNAL OF CANCER

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

(2014) Jennifer L Stamos et al.   eLife

Phosphorylation of unique domains of Src family kinases

(2014) Irene Amata et al.   Frontiers in Genetics

Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer

(2013) M. Shiota et al.   CANCER RESEARCH

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

(2013) Abby Sarkar et al.   Cell Stem Cell

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction

(2013) J. Green et al.   Cold Spring Harbor Perspectives in Biology

Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism

(2013) Yolanda Pérez et al.   Scientific Reports

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Glucose-Induced β-Catenin Acetylation Enhances Wnt Signaling in Cancer

(2012) Ana Chocarro-Calvo et al.   MOLECULAR CELL

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE

(2012) Shan-shan Lai et al.   Cancer Genetics

Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib

(2011) J. E. Cortes et al.   BLOOD

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75)

(2011) Q. Pan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

(2011) Helena J M Smartt et al.   GUT

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

The Small GTPase RhoA Localizes to the Nucleus and Is Activated by Net1 and DNA Damage Signals

(2011) Adi D. Dubash et al.   PLoS One

Myristoylation and Membrane Binding Regulate c-Src Stability and Kinase Activity

(2010) P. Patwardhan et al.   MOLECULAR AND CELLULAR BIOLOGY

Connexin43 inhibits the oncogenic activity of c-Src in C6 glioma cells

(2010) S Herrero-González et al.   ONCOGENE

Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study

(2009) Y. Liu et al.   HUMAN REPRODUCTION

Epidermal Growth Factor Receptor Translocation to the Mitochondria

(2009) Michelle L. Demory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dishevelled-2 docks and activates Src in a Wnt-dependent manner

(2009) Noriko Yokoyama et al.   JOURNAL OF CELL SCIENCE

Structural Characterization of the Natively Unfolded N-Terminal Domain of Human c-Src Kinase: Insights into the Role of Phosphorylation of the Unique Domain

(2009) Yolanda Pérez et al.   JOURNAL OF MOLECULAR BIOLOGY

The PHD domain is required to link Drosophila Pygopus to Legless/β-catenin and not to histone H3

(2009) Roman Kessler et al.   MECHANISMS OF DEVELOPMENT

KLF4 Interacts with  -Catenin/TCF4 and Blocks p300/CBP Recruitment by  -Catenin

(2009) P. M. Evans et al.   MOLECULAR AND CELLULAR BIOLOGY

β-Catenin hits chromatin: regulation of Wnt target gene activation

(2009) Christian Mosimann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation

(2009) D. J. Kemble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypoxia-Inducible Factor-1  Obstructs a Wnt Signaling Pathway by Inhibiting the hARD1-Mediated Activation of  -Catenin

(2008) J.-H. Lim et al.   CANCER RESEARCH

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

WGEF activates Rho in the Wnt–PCP pathway and controls convergent extension in Xenopus gastrulation

(2008) Kosuke Tanegashima et al.   EMBO JOURNAL

O-GlcNAc-glycosylation of β-catenin regulates its nuclear localization and transcriptional activity

(2008) Ria Sayat et al.   EXPERIMENTAL CELL RESEARCH

G o mediates WNT-JNK signaling through Dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells

(2008) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis

(2008) Kevin K. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

(2008) Kyung-Ah Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells

(2008) Pinella Buongiorno et al.   Molecular Cancer

TBL1–TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis

(2008) Jiong Li et al.   NATURE CELL BIOLOGY

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13

(2008) I. Carrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA