Recent updates on Wnt signaling modulators: a patent review (2014-2020)

A novel Bcl-2 inhibitor, BM-1197, induces apoptosis in malignant lymphoma cells through the endogenous apoptotic pathway

(2020) Yue-Li Sun et al.   BMC CANCER

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction

(2019) Zhen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Wnt Signaling Deregulation in the Aging and Alzheimer’s Brain

(2019) Ernest Palomer et al.   Frontiers in Cellular Neuroscience

Targeting cancer stem cells in drug discovery: Current state and future perspectives

(2019) Fang-Yu Du et al.   World Journal of Stem Cells

WNT Signaling in Disease

(2019) Ng et al.   Cells

Targeting the Side-Chain Convergence of Hydrophobic α-Helical Hot Spots To Design Small-Molecule Mimetics: Key Binding Features for i, i + 3, and i + 7

(2019) Zhen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

(2018) Min Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

(2018) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells

(2018) Prameet Kaur et al.   Genes

Wnt–β-catenin signalling in liver development, health and disease

(2018) Maria J. Perugorria et al.   Nature Reviews Gastroenterology & Hepatology

Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis

(2016) Tomas Valenta et al.   Cell Reports

Developmental Drift and the Role of Wnt Signaling in Aging

(2016) Jan Gruber et al.   Cancers

The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway

(2015) Sébastien Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sustained Activation of Wnt/ -Catenin Signaling Drives AKI to CKD Progression

(2015) L. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

β-catenin is overexpressed in hepatic fibrosis and blockage of Wnt/β-catenin signaling inhibits hepatic stellate cell activation

(2014) WEN-SONG GE et al.   Molecular Medicine Reports

Regulating Wnt signaling: a strategy to prevent neurodegeneration and induce regeneration

(2014) K. Harvey et al.   Journal of Molecular Cell Biology

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

(2014) S. A. Purro et al.   Journal of Molecular Cell Biology

The Development of Highly Potent Inhibitors for Porcupine

(2013) Xiaolei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

(2012) M Christie et al.   ONCOGENE

Upregulation of the Wnt Co-Receptor LRP6 Promotes Hepatocarcinogenesis and Enhances Cell Invasion

(2012) Edmund Kwok-Kwan Tung et al.   PLoS One

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations

(2011) T. Osada et al.   CANCER RESEARCH

The wnt/β-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer

(2011) Taj D. King et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

(2011) David P Minde et al.   Molecular Cancer

Wnt/β-catenin signaling regulates cancer stem cells in lung cancer A549 cells

(2010) Ying Teng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases

(2010) Ryohichi Sugimura et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis

(2009) Thor Ueland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry

(2009) Megan C. Yap et al.   JOURNAL OF LIPID RESEARCH

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

(2008) S. L. Lewis et al.   DEVELOPMENT