Signaling Pathways Involved in 5-FU Drug Resistance in Cancer

Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship

(2021) Mariagrazia Piscione et al.   Frontiers in Microbiology

Inhibition of Wnt/β-Catenin Signaling in Neuroendocrine Tumors In Vitro: Antitumoral Effects

(2020) Xi-Feng Jin et al.   Cancers

Silence of FAM83H-AS1 promotes chemosensitivity of gastric cancer through Wnt/β-catenin signaling pathway

(2020) Bing Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Frequent Activation of Notch Signaling Pathway in Colorectal Cancers and Its Implication in Patient Survival Outcome

(2020) Jilani Purusottapatnam Shaik et al.   Journal of Oncology

Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins

(2020) Adriana Gutiérrez-Hoya et al.   Cells

25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway

(2019) Saisai Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The role and mechanisms of action of microRNAs in cancer drug resistance

(2019) Wengong Si et al.   Clinical Epigenetics

Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase

(2019) Magdalena Milczarek et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cardamonin, a natural chalcone, reduces 5-fluorouracil resistance of gastric cancer cells through targeting Wnt/β-catenin signal pathway

(2019) Gaochao Hou et al.   INVESTIGATIONAL NEW DRUGS

Gene expression profiling of lung atypical carcinoids and large cell neuroendocrine carcinomas identifies three transcriptomic subtypes with specific genomic alterations

(2019) Michele Simbolo et al.   Journal of Thoracic Oncology

Pancreatic cancer—A disease in need: Optimizing and integrating supportive care

(2019) Gordon T. Moffat et al.   CANCER

Diagnostic Tumor Markers in Head and Neck Squamous Cell Carcinoma (HNSCC) in the Clinical Setting

(2019) Panagiota Economopoulou et al.   Frontiers in Oncology

Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation

(2019) Jinbo Fu et al.   Scientific Reports

Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer

(2018) N. O. Elander et al.   BRITISH JOURNAL OF CANCER

Current and emerging therapies for PNETs in patients with or without MEN1

(2018) Morten Frost et al.   Nature Reviews Endocrinology

Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer

(2018) Peiguang Niu et al.   Oncology Letters

HMGA2 enhances 5-fluorouracil chemoresistance in colorectal cancer via the Dvl2/Wnt pathway

(2018) Xi Xu et al.   Oncotarget

Dishevelled 1, a pivotal positive regulator of the Wnt signalling pathway, mediates 5-fluorouracil resistance in HepG2 cells

(2018) Yisong Xu et al.   Artificial Cells Nanomedicine and Biotechnology

Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC)

(2018) Yu Zhang et al.   MEDICAL SCIENCE MONITOR

LncNEN885 inhibits epithelial-mesenchymal transition by partially regulation of Wnt/β-catenin signalling in gastroenteropancreatic neuroendocrine neoplasms

(2018) Ya-Ling Wei et al.   CANCER SCIENCE

A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo

(2018) Dan-Dan Li et al.   CELL PROLIFERATION

Whole-genome landscape of pancreatic neuroendocrine tumours

(2017) Aldo Scarpa et al.   NATURE

GSK3α/β: A Novel Therapeutic Target for Neuroendocrine Tumors

(2017) Elke Tatjana Aristizabal Prada et al.   NEUROENDOCRINOLOGY

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

(2017) Chuanqing Wu et al.   OncoTargets and Therapy

Cardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-κB pathway in nasopharyngeal carcinoma

(2017) Yuting Li et al.   Cell Death & Disease

Clinical implications of dihydropyrimidine dehydrogenase expression in patients with pancreatic cancer who undergo curative resection with S-1 adjuvant chemotherapy

(2017) Masaaki Murakawa et al.   Oncology Letters

Celecoxib targets breast cancer stem cells by inhibiting the synthesis of prostaglandin E2 and down-regulating the Wnt pathway activity

(2017) Chaolin Huang et al.   Oncotarget

dUTPase inhibition augments replication defects of 5-Fluorouracil

(2017) Anna Hagenkort et al.   Oncotarget

NF‐κB Signaling in Gastric Cancer

(2017) Olga Sokolova et al.   Toxins

Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors

(2017) K E Lines et al.   Oncogenesis

miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis

(2017) Ci Zhao et al.   Scientific Reports

Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer

(2016) Jingwen Zhang et al.   APOPTOSIS

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1

(2016) Heyong Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFκB survival-signaling pathway

(2016) Yanting Kang et al.   OncoTargets and Therapy

Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer

(2015) Mehdi Shakibaei et al.   BMC CANCER

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

Elevated STAT3 Signaling-Mediated Upregulation of MMP-2/9 Confers Enhanced Invasion Ability in Multidrug-Resistant Breast Cancer Cells

(2015) Fei Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML

(2015) Li Tan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil

(2015) Arvind Pandey et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Blockage of PTPRJ promotes cell growth and resistance to 5-FU through activation of JAK1/STAT3 in the cervical carcinoma cell line C33A

(2015) CHUN-MEI YAN et al.   ONCOLOGY REPORTS

Differentially expressed gene profiles of intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and combined hepatocellular-cholangiocarcinoma by integrated microarray analysis

(2015) Tong-Chun Xue et al.   TUMOR BIOLOGY

Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells

(2015) Ning Wu et al.   TUMOR BIOLOGY

Let-7a suppresses glioma cell proliferation and invasion through TGF-β/Smad3 signaling pathway by targeting HMGA2

(2015) Yang Li et al.   TUMOR BIOLOGY

Acquisition of 5-fluorouracil resistance induces epithelial-mesenchymal transitions through the Hedgehog signaling pathway in HCT-8 colon cancer cells

(2015) YANJUN LIU et al.   Oncology Letters

Permeability of 5-fluorouracil and its prodrugs in Caco-2 cell monolayers: evidence for shift from paracellular to transcellular transport by prodrug formation

(2015) M. Imoto et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer

(2015) Tapati Mazumdar et al.   Oncotarget

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer

(2015) Akwasi Agyeman et al.   Oncotarget

Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis

(2015) Joyce P.Y. Mak et al.   Oncotarget

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

(2015) Qing Chang et al.   NEOPLASIA

Barrett's esophagus: cancer and molecular biology

(2014) Michael K. Gibson et al.   Annals of the New York Academy of Sciences

Icariin-Mediated Inhibition of NF-κB Activity Enhances the In Vitro and In Vivo Antitumour Effect of 5-Fluorouracil in Colorectal Cancer

(2014) De-Bing Shi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

An Overview on Cardamonin

(2014) Luís Moreira Gonçalves et al.   JOURNAL OF MEDICINAL FOOD

Notch1 is overexpressed in human intrahepatic cholangiocarcinoma and is associated with its proliferation, invasiveness and sensitivity to 5-fluorouracil in vitro

(2014) WEN-RUI WU et al.   ONCOLOGY REPORTS

Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours

(2014) Xiuli Jiang et al.   Nature Communications

Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinoma

(2013) Lifen Deng et al.   BMC CANCER

Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients

(2013) P A Candy et al.   BRITISH JOURNAL OF CANCER

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

(2013) Mallikarjun Patil et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nonsteroidal anti-inflammatory drugs suppress cancer stem cellsviainhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer

(2013) Chang Mo Moon et al.   INTERNATIONAL JOURNAL OF CANCER

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapyin vitroandin vivo

(2013) Melanie Spitzner et al.   INTERNATIONAL JOURNAL OF CANCER

Roles of Chk1 in cell biology and cancer therapy

(2013) Youwei Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits

(2013) SEYUNG S. CHUNG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

(2013) Kanjoormana A. Manu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Activation of STAT3 in Human Gastric Cancer Cells via Interleukin (IL)-6-Type Cytokine Signaling Correlates with Clinical Implications

(2013) Zhengguang Wang et al.   PLoS One

Regulation of nuclear factor-κB in autoimmunity

(2013) Shao-Cong Sun et al.   TRENDS IN IMMUNOLOGY

Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF- B signaling pathway in vitro and in vivo

(2012) F. Tian et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Targeting STAT3 in gastric cancer

(2012) Andrew S Giraud et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

Gene expression signatures of angiocidin and darapladib treatment connect to therapy options in cervical cancer

(2012) Martin Koch et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

(2012) J. H. van Es et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells

(2012) Yusuke Kishi et al.   NATURE NEUROSCIENCE

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Possible regulatory role of Snail in NF-κB-mediated changes in E-cadherin in gastric cancer

(2012) ZENAN HU et al.   ONCOLOGY REPORTS

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Effects of 5-fluorouracil and gemcitabine on a breast cancer cell line (MCF-7) via the JAK/STAT pathway

(2011) Elgin Turkoz Uluer et al.   ACTA HISTOCHEMICA

Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation

(2011) Xiaohua Zhang et al.   CANCER SCIENCE

Intestinal carcinogenesis: IKK can go all the way

(2011) Yoshiaki Sunami et al.   JOURNAL OF CLINICAL INVESTIGATION

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

(2011) C. S. Sorensen et al.   NUCLEIC ACIDS RESEARCH

Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells

(2010) Q. Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis

(2010) S Y Nam et al.   BRITISH JOURNAL OF CANCER

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Colon carcinogenesis: Learning from NF-κB and AP-1

(2010) Aristides G. Vaiopoulos et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PharmGKB summary: fluoropyrimidine pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

cDNA Microarray Gene Expression Profiling of Hedgehog Signaling Pathway Inhibition in Human Colon Cancer Cells

(2010) Ting Shi et al.   PLoS One

Beta-catenin signaling, liver regeneration and hepatocellular cancer: Sorting the good from the bad

(2010) Kari Nichole Nejak-Bowen et al.   SEMINARS IN CANCER BIOLOGY

PTCH1, a receptor of Hedgehog signaling pathway, is correlated with metastatic potential of colorectal cancer

(2010) Sihong You et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs

(2010) Koh Miura et al.   Cancers

Activation of Wnt/β-catenin signalling pathway induces chemoresistance to interferon-α/5-fluorouracil combination therapy for hepatocellular carcinoma

(2009) T Noda et al.   BRITISH JOURNAL OF CANCER

Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase

(2009) Andrea Réti et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

(2009) Travis H. Stracker et al.   DNA REPAIR

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

S-1: a promising new oral fluoropyrimidine derivative

(2009) Muhammad Wasif Saif et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3

(2009) Jang-Hyun Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular targeted therapy for hepatocellular carcinoma

(2009) Melanie Thomas   JOURNAL OF GASTROENTEROLOGY

Targeting NF- B signaling pathway suppresses tumor growth, angiogenesis, and metastasis of human esophageal cancer

(2009) B. Li et al.   MOLECULAR CANCER THERAPEUTICS

NF-κB signalling proteins p50/p105, p52/p100, RelA, and IKKε are over-expressed in oesophageal squamous cell carcinomas

(2009) Mi Ran Kang et al.   PATHOLOGY

Progress and challenges in understanding planar cell polarity signaling

(2009) Jeffrey D. Axelrod   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection

(2009) Alfredo Guglielmi et al.   WORLD JOURNAL OF SURGERY

Regulation of Chk1

(2009) Claudia Tapia-Alveal et al.   Cell Division

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Paeoniflorin suppress NF-κB activation through modulation of IκBα and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells

(2008) Hao Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer

(2008) Georg Lurje et al.   Pharmacogenetics and Genomics

Roles for CSN5 in control of p53/MDM2 activities

(2007) Xiao-Chun Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY