Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

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Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

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Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

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Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

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A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

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Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

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Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

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Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

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Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

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Structural Basis of Wnt Recognition by Frizzled

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Wnt5a Potentiates TGF-  Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

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A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

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The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

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Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

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Characterization of the Intestinal Cancer Stem Cell Marker CD166 in the Human and Mouse Gastrointestinal Tract

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Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

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OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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