WNT/β-catenin signaling in the development of liver cancers

TMEM9‐v‐ATPase Activates Wnt/β‐Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis

(2020) Youn‐Sang Jung et al.   HEPATOLOGY

Autophagy: Dual Response in the Development of Hepatocellular Carcinoma

(2019) Hamza Yazdani et al.   Cells

Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis

(2019) Rongkun Li et al.   Molecular Cancer

Genome-Wide Identification and Expression Profiling of Wnt Family Genes in the Silkworm, Bombyx mori

(2019) Xin Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates

(2019) Kristina N. Schaefer et al.   DEVELOPMENTAL CELL

Liver cancer: WISP3 suppresses hepatocellular carcinoma progression by negative regulation of β-catenin/TCF/LEF signalling

(2019) Hong Gao et al.   CELL PROLIFERATION

Molecular Pathogenesis of Cholangiocarcinoma

(2019) Peter L. Labib et al.   BMC CANCER

EGFR is required for Wnt9a–Fzd9b signalling specificity in haematopoietic stem cells

(2019) Stephanie Grainger et al.   NATURE CELL BIOLOGY

Cholangiocarcinoma

(2019) Adeel S. Khan et al.   SURGICAL CLINICS OF NORTH AMERICA

Gastrin promotes angiogenesis by activating HIF-1α/β-catenin/VEGF signaling in gastric cancer

(2019) E. Tang et al.   GENE

Molecular and histological correlations in liver cancer

(2019) Julien Calderaro et al.   JOURNAL OF HEPATOLOGY

The Mode of Stem Cell Division Is Dependent on the Differential Interaction of β-Catenin with the Kat3 Coactivators CBP or p300

(2019) Agnes I. Lukaszewicz et al.   Cancers

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

(2019) Dan Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Basil polysaccharide inhibits hypoxia-induced hepatocellular carcinoma metastasis and progression through suppression of HIF-1α-mediated epithelial-mesenchymal transition

(2019) Bing Feng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

WNT Signaling in Disease

(2019) Ng et al.   Cells

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

(2019) Qiang Gao et al.   CELL

LncRNA ASB16-AS1 Promotes Growth And Invasion Of Hepatocellular Carcinoma Through Regulating miR-1827/FZD4 Axis And Activating Wnt/β-Catenin Pathway

(2019) Xiaoxiao Yao et al.   Cancer Management and Research

Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

(2018) Jacquelyn O. Russell et al.   Annual Review of Pathology-Mechanisms of Disease

miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway

(2018) Rongchang Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

(2018) Amelie Griveau et al.   CANCER CELL

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

(2018) Nithya Krishnamurthy et al.   CANCER TREATMENT REVIEWS

Multiprotein complexes governing Wnt signal transduction

(2018) Melissa Gammons et al.   CURRENT OPINION IN CELL BIOLOGY

The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model

(2018) Na Zhan et al.   GENE EXPRESSION

Diagnosis, Staging and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

(2018) Jorge A. Marrero et al.   HEPATOLOGY

Long non-coding RNA CCAL promotes hepatocellular carcinoma progression by regulating AP-2α and Wnt/β-catenin pathway

(2018) Yu Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

(2018) Qing Fan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner

(2018) Xiaomin Fu et al.   Molecular Cancer

Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid

(2018) Xian-Yang Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling

(2018) Pei Hu et al.   OncoTargets and Therapy

β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin

(2018) Yuhua Chen et al.   Cell Death & Disease

Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma

(2018) Junwei Song et al.   Theranostics

Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo

(2018) Kristina N. Schaefer et al.   PLoS Genetics

Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis

(2018) Alexandre Vallée et al.   Frontiers in Immunology

SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer

(2018) Fei Han et al.   EBioMedicine

BCL9 promotes epithelial mesenchymal transition and invasion in cisplatin resistant NSCLC cells via β-catenin pathway

(2018) Yu Zhang et al.   LIFE SCIENCES

Role of hypoxia-induced exosomes in tumor biology

(2018) Chuchu Shao et al.   Molecular Cancer

Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor

(2018) Chong Li et al.   Scientific Reports

Androgen receptor drives hepatocellular carcinogenesis by activating enhancer of zeste homolog 2-mediated Wnt/β-catenin signaling

(2018) Haibin Song et al.   EBioMedicine

Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling

(2018) Wei Zheng et al.   BIOSCIENCE REPORTS

The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways

(2018) Anindita Tripathy et al.   PLoS One

HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma

(2017) Wenlin Yang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification

(2017) Julien Calderaro et al.   JOURNAL OF HEPATOLOGY

SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma

(2017) Maite Merino-Azpitarte et al.   JOURNAL OF HEPATOLOGY

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

(2017) Pietro Lampertico et al.   JOURNAL OF HEPATOLOGY

Cholangiocarcinoma — evolving concepts and therapeutic strategies

(2017) Sumera Rizvi et al.   Nature Reviews Clinical Oncology

A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation

(2017) Claudio Cantù et al.   Science Signaling

UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway

(2017) Jiahui Mao et al.   STEM CELLS

Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer

(2017) Heather C. Bruner et al.   Cold Spring Harbor Perspectives in Biology

A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation

(2017) Claudio Cantù et al.   Science Signaling

Chitosan promotes cancer progression and stem cell properties in association with Wnt signaling in colon and hepatocellular carcinoma cells

(2017) Po-Hsiang Chang et al.   Scientific Reports

Synergistic effects of CD44 and TGF-β1 through AKT/GSK-3β/β-catenin signaling during epithelial-mesenchymal transition in liver cancer cells

(2016) Na Ri Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/β-catenin signaling pathway

(2016) Yun-yun Peng et al.   CANCER LETTERS

Wnt5b-associated exosomes promote cancer cell migration and proliferation

(2016) Takeshi Harada et al.   CANCER SCIENCE

Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin

(2016) Junyan Tao et al.   HEPATOLOGY

Direct Pharmacological Inhibition of  -Catenin by RNA Interference in Tumors of Diverse Origin

(2016) S. Ganesh et al.   MOLECULAR CANCER THERAPEUTICS

lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

(2016) Pingping Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aberrant regulation of Wnt signaling in hepatocellular carcinoma

(2016) Li-Juan Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

(2016) Pingping Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dickkopf-1 expression is associated with tumorigenity and lymphatic metastasis in human hilar cholangiocarcinoma

(2016) Xiang-de Shi et al.   Oncotarget

Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis

(2016) Yuan Tian et al.   Cancers

The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling

(2015) Yanying Wang et al.   Cell Stem Cell

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

(2015) Satdarshan Pal Monga   GASTROENTEROLOGY

βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin

(2015) Xiuling Zhi et al.   HEPATOLOGY

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

(2015) Luke Boulter et al.   JOURNAL OF CLINICAL INVESTIGATION

Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

(2015) Jinghan Wang et al.   Oncotarget

Frizzled-7 promoter is highly active in tumors and promoter-driven Shiga-like toxin I inhibits hepatocellular carcinoma growth

(2015) Hongpan Xu et al.   Oncotarget

PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma

(2014) Tingting Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Taranjit S. Gujral et al.   CELL

Promoter Methylation ofSFRP3Is Frequent in Hepatocellular Carcinoma

(2014) Ya-Wen Lin et al.   DISEASE MARKERS

The potential of targeting Wnt/β-catenin in colon cancer

(2014) Ana Sebio et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

FAK Is required for c-Met/β-catenin-driven hepatocarcinogenesis

(2014) Na Shang et al.   HEPATOLOGY

�-Catenin(CTNNB1)Mutations Are Not Associated with Prognosis in Advanced Hepatocellular Carcinoma

(2014) Li-Chun Lu et al.   ONCOLOGY

Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells

(2014) Watcharin Loilome et al.   TUMOR BIOLOGY

Toggling a conformational switch in Wnt/β-catenin signaling: Regulation of Axin phosphorylation

(2013) Ofelia Tacchelly-Benites et al.   BIOESSAYS

Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway

(2013) Benjamin Goeppert et al.   HEPATOLOGY

Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-Catenin signaling

(2013) Dan Xu et al.   HEPATOLOGY

Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs

(2013) Floriane Pez et al.   JOURNAL OF HEPATOLOGY

DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway

(2013) Liang Chen et al.   Molecular Cancer

Inhibition of Wnt signaling induces cell apoptosis and suppresses cell proliferation in cholangiocarcinoma cells

(2013) KUN-SONG ZHANG et al.   ONCOLOGY REPORTS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

PTEN-mediated akt/β-Catenin/foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury

(2012) Naoko Kamo et al.   HEPATOLOGY

Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis

(2012) Giray Bozkaya et al.   Molecular Cancer

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted and Transmembrane Wnt Inhibitors and Activators

(2012) C.-M. Cruciat et al.   Cold Spring Harbor Perspectives in Biology

Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin

(2011) Wei Wei et al.   Molecular Cancer

Resistance or sensitivity of Wilms’ tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target

(2011) N Pode-Shakked et al.   ONCOGENE

β-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription

(2010) Fei-Yan Pan et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma

(2010) Sarah Beseme Nambotin et al.   JOURNAL OF HEPATOLOGY

Noncanonical Wnt11 Inhibits Hepatocellular Carcinoma Cell Proliferation and Migration

(2010) T. Toyama et al.   MOLECULAR CANCER RESEARCH

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver

(2009) Lisa Longato et al.   HEPATOLOGY

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

(2009) Haluk Yuzugullu et al.   Molecular Cancer

Molecular components of the adherens junction

(2008) Carien M. Niessen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

(2008) A Bengochea et al.   BRITISH JOURNAL OF CANCER