Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Development of Akt-activated GSK3β inhibitory peptide

(2013) Jin-Sik Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt Stabilization of  -Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies

(2013) S.-E. Kim et al.   SCIENCE

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

(2013) Meera Soundararajan et al.   STRUCTURE

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

(2012) B. T. MacDonald et al.   Cold Spring Harbor Perspectives in Biology

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

The Possible Involvement of Glycogen Synthase Kinase-3 (GSK-3) in Diabetes, Cancer and Central Nervous System Diseases

(2011) Amar S. et al.   CURRENT PHARMACEUTICAL DESIGN

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

(2011) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Regulation of Lrp6 phosphorylation

(2010) Christof Niehrs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

(2010) Miriam López-Ramos et al.   FASEB JOURNAL

Mitogen-Activated Protein Kinases Promote WNT/ -Catenin Signaling via Phosphorylation of LRP6

(2010) I. Cervenka et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamics connect substrate recognition to catalysis in protein kinase A

(2010) Larry R Masterson et al.   Nature Chemical Biology

cAMP-dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

(2010) Madhusudan et al.   PROTEIN SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases

(2009) Tara L. Davis et al.   FEBS Journal

GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics

(2009) Akihiko Wada   Frontiers in Bioscience-Landmark

G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway

(2009) Minyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Inhibitors of the Wnt/β-Catenin Signaling Pathway as Novel Anticancer Drugs

(2009) Fumi Takahashi-Yanaga et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

(2009) Geng Wu et al.   PLoS One

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

(2009) Oksana Kaidanovich-Beilin et al.   Molecular Brain

Synthesis and structure based optimization of novel Akt inhibitors

(2008) Blaise Lippa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6

(2008) Bryan T. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-Specific Role of Glycogen Synthase Kinase 3  in Glucose Homeostasis and Insulin Action

(2008) S. Patel et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One