Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis

Multi-organ proteomic landscape of COVID-19 autopsies

(2021) Xiu Nie et al.   CELL

Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling

(2021) Jason J Gokey et al.   THORAX

Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells

(2021) Dawei Yang et al.   LIFE SCIENCES

Virus-induced senescence is driver and therapeutic target in COVID-19

(2021) Soyoung Lee et al.   NATURE

A single-cell transcriptomic landscape of the lungs of patients with COVID-19

(2021) Si Wang et al.   NATURE CELL BIOLOGY

Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice

(2021) Kexiong Zhang et al.   Cells

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

(2020) Yonghan He et al.   AGING CELL

Ineffectual AEC2-to-AEC1 Differentiation in IPF: Persistence of KRT8hi Transitional State

(2020) Peng Jiang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration

(2020) Jaymin J. Kathiriya et al.   Cell Stem Cell

The Histone Code of Senescence

(2020) Harikrishnareddy Paluvai et al.   Cells

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

Galactose‐modified duocarmycin prodrugs as senolytics

(2020) Ana Guerrero et al.   AGING CELL

Identification of SYK inhibitor, R406 as a novel senolytic agent

(2020) Hyun-Ji Cho et al.   Aging-US

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

(2020) Wei Rao et al.   CELL

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model

(2020) Eva Schruf et al.   FASEB JOURNAL

Biology of extracellular vesicles secreted from senescent cells as senescence‐associated secretory phenotype factors

(2020) Tomoka Misawa et al.   Geriatrics & Gerontology International

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

(2020) Satish Sati et al.   MOLECULAR CELL

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

(2020) Mami Yasukawa et al.   Nature Communications

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

(2020) Yonghan He et al.   Nature Communications

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

(2020) Masahiro Wakita et al.   Nature Communications

Extracellular Vesicles from Fibroblasts Induce Epithelial Cell Senescence in Pulmonary Fibrosis

(2020) Tsukasa Kadota et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pulmonary alveolar regeneration in adult COVID-19 patients

(2020) Jingyu Chen et al.   CELL RESEARCH

Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

(2020) Jinwook Choi et al.   Cell Stem Cell

Glycogen synthase kinase‐3β promotes radiation‐induced lung fibrosis by regulating β‐catenin/lin28 signaling network to determine type II alveolar stem cell transdifferentiation state

(2020) Tingting Zhang et al.   FASEB JOURNAL

Diffuse Alveolar Damage (DAD) from Coronavirus Disease 2019 Infection is Morphologically Indistinguishable from Other Causes of DAD

(2020) Kristine E. Konopka et al.   HISTOPATHOLOGY

ETS variant transcription factor 5 and c-Myc cooperate in derepressing the human telomerase gene promoter via composite ETS/E-box motifs

(2020) Fan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

(2020) Yoshihiko Kobayashi et al.   NATURE CELL BIOLOGY

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

(2020) Maximilian Strunz et al.   Nature Communications

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

(2020) Arun C. Habermann et al.   Science Advances

Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis

(2020) Changfu Yao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study

(2020) Thomas M Drake et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping

(2020) Lihui Wang et al.   Cell Metabolism

Cellular Senescence: Friend or Foe to Respiratory Viral Infections?

(2020) William J. Kelley et al.   EUROPEAN RESPIRATORY JOURNAL

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

(2020) Ameen A. Salahudeen et al.   NATURE

Lung transplantation for patients with severe COVID-19

(2020) Ankit Bharat et al.   Science Translational Medicine

ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk Factors

(2020) Zofia Wicik et al.   Journal of Clinical Medicine

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells

(2019) Andrew Khayrullin et al.   Cells

Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing

(2019) Jun Liu et al.   Cells

The curcumin analog EF24 is a novel senolytic agent

(2019) Wen Li et al.   Aging-US

Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

(2019) Arda Halu et al.   HUMAN MOLECULAR GENETICS

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

(2019) Hosni Cherif et al.   Journal of Clinical Medicine

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

(2019) Xiaotian Yuan et al.   ONCOGENE

Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis

(2019) Kuei-Pin Chung et al.   Nature Communications

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

(2019) Uxía Nogueira-Recalde et al.   EBioMedicine

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction

(2019) Wei Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP

(2019) Wang Peilin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells

(2019) Huijuan Wu et al.   CELL

Role of telomerase in the tumour microenvironment

(2019) Ning Liu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells

(2018) Mikhail Baryshev et al.   CELL CYCLE

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

(2018) Sona Hubackova et al.   CELL DEATH AND DIFFERENTIATION

Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation

(2018) Mei-I Chung et al.   DEVELOPMENT

Nucleotide-resolution genome-wide mapping of oxidative DNA damage by click-code-seq

(2018) Junzhou Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

(2018) Shengda Lin et al.   NATURE

Reducing protein oxidation reverses lung fibrosis

(2018) Vikas Anathy et al.   NATURE MEDICINE

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

Two-Step Senescence-Focused Cancer Therapies

(2018) Cynthia J. Sieben et al.   TRENDS IN CELL BIOLOGY

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

(2018) Juan Manuel Povedano et al.   eLife

Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study

(2018) Amy Dressen et al.   Lancet Respiratory Medicine

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts

(2018) Neetu Razdan et al.   AGING CELL

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest

(2018) José Reyes et al.   MOLECULAR CELL

Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

(2018) Bela Ozsvari et al.   Aging-US

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling

(2017) Jeong-Han Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

(2017) Guoying Yu et al.   NATURE MEDICINE

Spatial and Temporal Control of Senescence

(2017) Yoko Ito et al.   TRENDS IN CELL BIOLOGY

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study

(2017) Brett Ley et al.   Lancet Respiratory Medicine

A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC

(2017) Leleesha Samaraweera et al.   Scientific Reports

Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

(2016) L. A. Maciel-Barón et al.   AGE

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

Alveolar Epithelial Disintegrity in Pulmonary Fibrosis

(2016) Tejaswini Kulkarni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

(2016) Jens C. Schmidt et al.   CELL

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

GermlineSFTPA1mutation in familial idiopathic interstitial pneumonia and lung cancer

(2016) Nadia Nathan et al.   HUMAN MOLECULAR GENETICS

De NovoRNA Synthesis by RNA-Dependent RNA Polymerase Activity of Telomerase Reverse Transcriptase

(2016) Yoshiko Maida et al.   MOLECULAR AND CELLULAR BIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

A balance between elongation and trimming regulates telomere stability in stem cells

(2016) Teresa Rivera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor

(2016) Ning Liu et al.   NUCLEIC ACIDS RESEARCH

Derepression ofhTERTgene expression promotes escape from oncogene-induced cellular senescence

(2016) Priyanka L. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

A balance between elongation and trimming regulates telomere stability in stem cells

(2016) Teresa Rivera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

(2016) Lucy Cassar et al.   Protein & Cell

Reemergence of Hedgehog Mediates Epithelial–Mesenchymal Crosstalk in Pulmonary Fibrosis

(2015) Biao Hu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

(2015) Zhengwei Xie et al.   CELL

Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs

(2015) Ruping Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening

(2015) Bridget D Stuart et al.   NATURE GENETICS

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Telomere dysfunction causes alveolar stem cell failure

(2015) Jonathan K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

(2015) Juan M. Povedano et al.   Cell Reports

Senescence-Associated Secretory Phenotype and Its Possible Role in Chronic Obstructive Pulmonary Disease

(2014) Manish Kumar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1

(2014) Y. Guo et al.   BLOOD

Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

(2014) Ryan J. Davis et al.   CANCER CELL

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Cellular senescence occurred widespread to multiple selective sites in the fetal tissues and organs of mice

(2014) Kexiong Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1

(2014) Hande Kocak et al.   GENES & DEVELOPMENT

Telomerase mutations in smokers with severe emphysema

(2014) Susan E. Stanley et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian Cells

(2014) Elisa Coluzzi et al.   PLoS One

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

WNT/β-Catenin Signaling Induces IL-1β Expression by Alveolar Epithelial Cells in Pulmonary Fibrosis

(2013) Verena Aumiller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary fibrosis on multidetector computed tomography and mortality in patients with radiation-associated cardiac disease undergoing cardiac surgery

(2013) Milind Y. Desai et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Bedside to Gene and Back in Idiopathic Pulmonary Fibrosis

(2013) William O.C. Cookson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Oxidative stress and pulmonary fibrosis

(2012) Paul Cheresh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human telomere disease due to disruption of the CCAAT box of the TERC promoter

(2012) A. M. Aalbers et al.   BLOOD

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

Telomerase deficiency does not alter bleomycin-induced fibrosis in mice

(2012) Amber L. Degryse et al.   EXPERIMENTAL LUNG RESEARCH

Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP)

(2012) Beiyun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Association between Variations in Cell Cycle Genes and Idiopathic Pulmonary Fibrosis

(2012) Nicoline M. Korthagen et al.   PLoS One

The pathogenesis of COPD and IPF: Distinct horns of the same devil?

(2012) Marco Chilosi et al.   RESPIRATORY RESEARCH

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment

(2011) Amber L. Degryse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis

(2011) Cecilia Marmai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

(2011) Daniel J. Schneider et al.   FASEB JOURNAL

Alveolar Epithelial Cells Undergo Epithelial-to-Mesenchymal Transition in Response to Endoplasmic Reticulum Stress

(2011) Harikrishna Tanjore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Combined pulmonary fibrosis and emphysema syndrome associated with familial SFTPC mutation

(2011) V. Cottin et al.   THORAX

Ancestral Mutation in Telomerase Causes Defects in Repeat Addition Processivity and Manifests As Familial Pulmonary Fibrosis

(2011) Jonathan K. Alder et al.   PLoS Genetics

Molecular regulation of telomerase activity in aging

(2011) Craig Nicholls et al.   Protein & Cell

Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo

(2011) Sharyn Bayne et al.   Protein & Cell

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis

(2010) T Namba et al.   CELL DEATH AND DIFFERENTIATION

Patented inhibitors of p53–Mdm2 interaction (2006 – 2008)

(2010) Lutz Weber   EXPERT OPINION ON THERAPEUTIC PATENTS

Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis

(2010) Min Li et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β induces telomerase-dependent pancreatic tumor cell cycle arrest

(2010) Lucy Cassar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer

(2009) Lisa Mirabello et al.   AGING CELL

Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis

(2009) Harikrishna Tanjore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Syndromes of Telomere Shortening

(2009) Mary Armanios   Annual Review of Genomics and Human Genetics

Ets2 transcription factor, telomerase activity and breast cancer

(2009) Julie M Dwyer et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Retraction

(2009)   FASEB JOURNAL

Multiple roles for MRE11 at uncapped telomeres

(2009) Yibin Deng et al.   NATURE

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

(2009) Yoshiko Maida et al.   NATURE

Cdk2 suppresses cellular senescence induced by the c-myc oncogene

(2009) Stefano Campaner et al.   NATURE CELL BIOLOGY

Lung alveolar integrity is compromised by telomere shortening in telomerase-null mice

(2008) Jooeun Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Bone Morphogenetic Protein-7 Inhibits Telomerase Activity, Telomere Maintenance, and Cervical Tumor Growth

(2008) L. Cassar et al.   CANCER RESEARCH

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

(2008) B. D. Lehmann et al.   CANCER RESEARCH

Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice

(2008) Sharyn Bayne et al.   CELL RESEARCH

Ets2 Maintains hTERT Gene Expression and Breast Cancer Cell Proliferation by Interacting with c-Myc

(2008) Dakang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis

(2008) Kevin K. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

(2008) J. K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fission Yeast Pot1-Tpp1 Protects Telomeres and Regulates Telomere Length

(2008) T. Miyoshi et al.   SCIENCE