A balance between elongation and trimming regulates telomere stability in stem cells

A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

(2016) Akshay K. Ahuja et al.   Nature Communications

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

(2015) Diane H Moon et al.   NATURE GENETICS

Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients

(2015) Bai-Wei Gu et al.   PLoS One

SMARCAL1 maintains telomere integrity during DNA replication

(2015) Lisa A. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

(2014) Alec N. Sexton et al.   GENES & DEVELOPMENT

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

5′ C-rich telomeric overhangs are an outcome of rapid telomere truncation events

(2013) Liana Oganesian et al.   DNA REPAIR

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells

(2013) Sicong Zeng et al.   JOURNAL OF CELL SCIENCE

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs

(2013) Thomas Winkler et al.   JOURNAL OF CLINICAL INVESTIGATION

TeloTool: a new tool for telomere length measurement from terminal restriction fragment analysis with improved probe intensity correction

(2013) Janett Göhring et al.   NUCLEIC ACIDS RESEARCH

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells

(2011) Fang Wang et al.   CELL RESEARCH

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

(2011) Athanasia D Panopoulos et al.   CELL RESEARCH

Normal mammalian cells negatively regulate telomere length by telomere trimming

(2011) H. A. Pickett et al.   HUMAN MOLECULAR GENETICS

Mammalian 5′ C-Rich Telomeric Overhangs Are a Mark of Recombination-Dependent Telomere Maintenance

(2011) Liana Oganesian et al.   MOLECULAR CELL

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

(2011) Luis F. Z. Batista et al.   NATURE

Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells

(2011) Athanasia D. Panopoulos et al.   PLoS One

A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity

(2010) Sergio Ruiz et al.   CURRENT BIOLOGY

Zscan4 regulates telomere elongation and genomic stability in ES cells

(2010) Michal Zalzman et al.   NATURE

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

(2010) Suneet Agarwal et al.   NATURE

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

Control of telomere length by a trimming mechanism that involves generation of t-circles

(2009) Hilda A Pickett et al.   EMBO JOURNAL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

(2009) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

C. elegans Telomeres Contain G-Strand and C-Strand Overhangs that Are Bound by Distinct Proteins

(2008) Marcela Raices et al.   CELL

Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized Cells

(2008) A. Nabetani et al.   MOLECULAR AND CELLULAR BIOLOGY