CDK1 dependent phosphorylation of hTERT contributes to cancer progression

Role of cyclin‐dependent kinases (CDKs) in hepatocellular carcinoma: Therapeutic potential of targeting the CDK signaling pathway

(2019) Shen Shen et al.   HEPATOLOGY RESEARCH

High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma

(2019) Junjie Piao et al.   GENE

FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression

(2018) Marten Hornsveld et al.   CANCER RESEARCH

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein

(2018) Yoshiko Maida et al.   Jove-Journal of Visualized Experiments

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A reproducible and scalable procedure for preparing bacterial extracts for cell-free protein synthesis

(2017) Kazushige Katsura et al.   JOURNAL OF BIOCHEMISTRY

Mutations in the promoter of the telomerase geneTERTcontribute to tumorigenesis by a two-step mechanism

(2017) Kunitoshi Chiba et al.   SCIENCE

Mitotic transcription and waves of gene reactivation during mitotic exit

(2017) Katherine C. Palozola et al.   SCIENCE

Gene expression profiling, pathway analysis and subtype classification reveal molecular heterogeneity in hepatocellular carcinoma and suggest subtype specific therapeutic targets

(2017) Rahul Agarwal et al.   Cancer Genetics

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

(2016) Jens C. Schmidt et al.   CELL

Leucocyte telomere length, genetic variants at the TERT gene region and risk of pancreatic cancer

(2016) Ying Bao et al.   GUT

TERTpromoter mutations in melanoma survival

(2016) Eduardo Nagore et al.   INTERNATIONAL JOURNAL OF CANCER

De NovoRNA Synthesis by RNA-Dependent RNA Polymerase Activity of Telomerase Reverse Transcriptase

(2016) Yoshiko Maida et al.   MOLECULAR AND CELLULAR BIOLOGY

Understanding TERT Promoter Mutations: A Common Path to Immortality

(2016) R. J. A. Bell et al.   MOLECULAR CANCER RESEARCH

Cyclin-Dependent Kinase Activity Correlates with the Prognosis of Patients Who Have Gastrointestinal Stromal Tumors

(2015) Toshirou Nishida et al.   ANNALS OF SURGICAL ONCOLOGY

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

(2015) Nuala A. O'Leary et al.   NUCLEIC ACIDS RESEARCH

TERTpromoter mutations and telomerase reactivation in urothelial cancer

(2015) Sumit Borah et al.   SCIENCE

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

Gateways to the FANTOM5 promoter level mammalian expression atlas

(2015) Marina Lizio et al.   GENOME BIOLOGY

High nuclear/cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patients

(2015) Wen-Wei Sung et al.   BMC CANCER

The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer

(2014) Linna Su et al.   BMC CANCER

Involvement of Telomerase Reverse Transcriptase in Heterochromatin Maintenance

(2014) Y. Maida et al.   MOLECULAR AND CELLULAR BIOLOGY

A promoter-level mammalian expression atlas

(2014)   NATURE

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT

(2014) Linghe Xi et al.   NUCLEIC ACIDS RESEARCH

A Genome-Wide RNAi Screen Identifies FOXO4 as a Metastasis-Suppressor through Counteracting PI3K/AKT Signal Pathway in Prostate Cancer

(2014) Bing Su et al.   PLoS One

CDK1 and CDK2 activity is a strong predictor of renal cell carcinoma recurrence

(2014) Fumiya Hongo et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Dyrk2-associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation

(2013) Hae-Yun Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of a Human IκB Kinase β Asymmetric Dimer

(2013) Shenping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Many disease-associated variants of hTERT retain high telomerase enzymatic activity

(2013) Arthur J. Zaug et al.   NUCLEIC ACIDS RESEARCH

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation

(2012) J. Chung et al.   JOURNAL OF CELL SCIENCE

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

(2012) M. K. Diril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

(2011) Yukiko Okada-Katsuhata et al.   NUCLEIC ACIDS RESEARCH

Maintenance of tumor initiating cells of defined genetic composition by nucleostemin

(2011) N. Okamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells

(2010) D. Canella et al.   GENOME RESEARCH

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression

(2009) Shang Li et al.   CELL

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

(2009) Yoshiko Maida et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE

(2009) Eiji Kinoshita et al.   Nature Protocols

A sensitive direct human telomerase activity assay

(2008) Scott B Cohen et al.   NATURE METHODS

CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor

(2008) P Liu et al.   ONCOGENE

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of FOXO1 by Cdk1 in Cycling Cells and Postmitotic Neurons

(2008) Z. Yuan et al.   SCIENCE