Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity
Authors
Keywords
-
Journal
AGING CELL
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-02-17
DOI
10.1111/acel.13117
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cellular Senescence and Radiation-induced Pulmonary Fibrosis
- (2019) Yonghan He et al. Translational Research
- The curcumin analog EF24 is a novel senolytic agent
- (2019) Wen Li et al. Aging-US
- USP7: Structure, substrate specificity, and inhibition
- (2019) Alexandra Pozhidaeva et al. DNA REPAIR
- USP7: Target Validation and Drug Discovery for Cancer Therapy
- (2018) Jin Zhou et al. Medicinal Chemistry
- MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
- (2017) Veronica Tisato et al. Journal of Hematology & Oncology
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones
- (2017) Giovanna Carrà et al. Oncotarget
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells
- (2016) Gibok Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Multiple facets of p53 in senescence induction and maintenance
- (2016) Yoshikazu Johmura et al. CANCER SCIENCE
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma
- (2016) Omid Tavana et al. NATURE MEDICINE
- Senescent intimal foam cells are deleterious at all stages of atherosclerosis
- (2016) B. G. Childs et al. SCIENCE
- SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
- (2016) Yoshikazu Johmura et al. Nature Communications
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- (2016) Marco Demaria et al. Cancer Discovery
- Regulation of p53 during senescence in normal human keratinocytes
- (2015) Reuben H. Kim et al. AGING CELL
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53
- (2015) Kristina Kirschner et al. PLoS Genetics
- Temporally distinct roles of ATM and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence
- (2014) R. R. Nair et al. JOURNAL OF CELL SCIENCE
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Senescence and aging: the critical roles of p53
- (2013) A Rufini et al. ONCOGENE
- USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis
- (2013) Y-H Fan et al. Cell Death & Disease
- A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance
- (2012) Dharminder Chauhan et al. CANCER CELL
- Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
- (2012) R M Naylor et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- CHIP-dependent p53 regulation occurs specifically during cellular senescence
- (2010) Christina Sisoula et al. FREE RADICAL BIOLOGY AND MEDICINE
- Modes of p53 Regulation
- (2009) Jan-Philipp Kruse et al. CELL
- Transcription-independent p53 apoptosis: an alternative route to death
- (2009) Daniel Speidel TRENDS IN CELL BIOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started