Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells

Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes

(2018) Brittany A. Law et al.   FASEB JOURNAL

Plasma Sphingolipids are Associated With Gait Parameters in the Mayo Clinic Study of Aging

(2017) Alexandra M V Wennberg et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence

(2017) Colleen Davis et al.   TISSUE ENGINEERING PART A

Bone Density and Brain Atrophy in Early Alzheimer's Disease

(2017) Natalia Loskutova et al.   JOURNAL OF ALZHEIMERS DISEASE

A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents

(2017) Inas Helwa et al.   PLoS One

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

(2017) Erez Eitan et al.   Scientific Reports

Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging

(2016) Elisa Fabbri et al.   AGING CELL

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line

(2016) Maria Podbielska et al.   JOURNAL OF LIPID RESEARCH

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Serum-derived exosomes from mice with highly metastatic breast cancer transfer increased metastatic capacity to a poorly metastatic tumor

(2016) Reginald M. Gorczynski et al.   Cancer Medicine

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

(2016) Mark A. Rider et al.   Scientific Reports

Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles’ characteristics compared to precipitating agents

(2016) Ana Gámez-Valero et al.   Scientific Reports

Lipidomics: Novel insight into the biochemical mechanism of lipid metabolism and dysregulation-associated disease

(2015) Ying-Yong Zhao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

(2015) María José Hernández-Corbacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

(2015) Joel Z. Nordin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties

(2015) Mariana Figuera-Losada et al.   PLoS One

Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans

(2014) Roy G. Cutler et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer

(2014) Ramesh Singh et al.   Molecular Cancer

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Characterising the Inhibitory Actions of Ceramide upon Insulin Signaling in Different Skeletal Muscle Cell Models: A Mechanistic Insight

(2014) Rana Mahfouz et al.   PLoS One

Frailty and Incident Dementia

(2013) S. L. Gray et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Effects of the activin A–myostatin–follistatin system on aging bone and muscle progenitor cells

(2012) Matthew Bowser et al.   EXPERIMENTAL GERONTOLOGY

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

(2012) Sadanand Fulzele et al.   Stem Cell Research

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Mammalian ceramide synthases

(2010) Michal Levy et al.   IUBMB LIFE

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes

(2008) Guanghu Wang et al.   GLIA

Age-Related Changes in the Osteogenic Differentiation Potential of Mouse Bone Marrow Stromal Cells

(2008) Weixi Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Serum sphingomyelins and ceramides are early predictors of memory impairment

(2008) Michelle M. Mielke et al.   NEUROBIOLOGY OF AGING

Ceramide starves cells to death by downregulating nutrient transporter proteins

(2008) G. G. Guenther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA