Cardiovascular Inflammaging: Mechanisms and Translational Aspects

Emerging Role of cAMP/AMPK Signaling

(2022) Muhammad Aslam et al.   Cells

The Complex Dance of Organelles during Mitochondrial Division

(2021) Luis-Carlos Tábara et al.   TRENDS IN CELL BIOLOGY

Gut microbiota as the key controllers of “healthy” aging of elderly people

(2021) Emeline Ragonnaud et al.   Immunity & Ageing

Terminally Differentiated CD4+ T Cells Promote Myocardial Inflammaging

(2021) Murilo Delgobo et al.   Frontiers in Immunology

mtDNA Heteroplasmy at the Core of Aging-Associated Heart Failure. An Integrative View of OXPHOS and Mitochondrial Life Cycle in Cardiac Mitochondrial Physiology

(2021) Alvaro A. Elorza et al.   Frontiers in Cell and Developmental Biology

Effects of Aging on Cardiac Oxidative Stress and Transcriptional Changes in Pathways of Reactive Oxygen Species Generation and Clearance

(2021) Farhan Rizvi et al.   Journal of the American Heart Association

Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models

(2021) Verónica A. García-García et al.   Cells

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Mitochondrial DNA heteroplasmy in disease and targeted nuclease‐based therapeutic approaches

(2020) Nadee Nissanka et al.   EMBO REPORTS

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

(2020) Tarini Shankar Ghosh et al.   GUT

The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions

(2020) Marius Trøseid et al.   EBioMedicine

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Glycolysis – a key player in the inflammatory response

(2020) Gonzalo Soto‐Heredero et al.   FEBS Journal

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Gut microbiota and cardiovascular disease: opportunities and challenges

(2020) Negin Kazemian et al.   Microbiome

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

(2020) Guo Chen et al.   Frontiers in Cell and Developmental Biology

Arginase inhibition by (−)-Epicatechin reverses endothelial cell aging

(2020) Alejandra Garate-Carrillo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microbiome definition re-visited: old concepts and new challenges

(2020) Gabriele Berg et al.   Microbiome

Nox1/4 inhibition exacerbates age dependent perivascular inflammation and fibrosis in a model of spontaneous hypertension

(2020) R. Nosalski et al.   PHARMACOLOGICAL RESEARCH

Microbiomes other than the gut: inflammaging and age-related diseases

(2020) Aurelia Santoro et al.   Seminars in Immunopathology

Alterations of monocyte NF-κB p65/RelA signaling in a cohort of older medical patients, age-matched controls, and healthy young adults

(2020) Juliette Tavenier et al.   Immunity & Ageing

Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease

(2020) Wei He et al.   Clinical Interventions in Aging

Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria

(2020) Huanhuan Xu et al.   Frontiers in Cell and Developmental Biology

Dilated cardiomyopathy impairs mitochondrial biogenesis and promotes inflammation in an age- and sex-dependent manner

(2020) Maria Luisa Barcena et al.   Aging-US

Mitochondria-Targeted Drug Delivery in Cardiovascular Disease: A Long Road to Nano-Cardio Medicine

(2020) Francesca Forini et al.   Pharmaceutics

Sex differences in the aging human heart: decreased sirtuins, pro-inflammatory shift and reduced anti-oxidative defense

(2019) Maria Luisa Barcena de Arellano et al.   Aging-US

Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasis

(2019) Vignesh Jayarajan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fecal Microbial Transplantation and Its Potential Application in Cardiometabolic Syndrome

(2019) Avner Leshem et al.   Frontiers in Immunology

The gut microbiome and atherosclerosis: current knowledge and clinical potential

(2019) Adilah Ahmad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Paradox of Coenzyme Q10 in Aging

(2019) Díaz-Casado et al.   Nutrients

Segregation of age-related skin microbiome characteristics by functionality

(2019) Hye-Jin Kim et al.   Scientific Reports

Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease

(2019) Carmen Roncal et al.   Scientific Reports

Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target

(2019) Shengjie Yang et al.   Frontiers in Pharmacology

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Epigenetics and Immunometabolism in Diabetes and Aging

(2018) Tomasz J. Guzik et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

(2018) Charles S. Dela Cruz et al.   MITOCHONDRION

Implication of G Protein-Coupled Receptor 43 in Intestinal Inflammation: A Mini-Review

(2018) Guan Yang et al.   Frontiers in Immunology

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases

(2018) Subash Chandra Gupta et al.   Frontiers in Immunology

Fecal microbiota transplantation alleviates myocardial damage in myocarditis by restoring the microbiota composition

(2018) Xiao-Fan Hu et al.   PHARMACOLOGICAL RESEARCH

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle

(2018) Harumasa Nakazawa et al.   FEBS Open Bio

Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?

(2017) M.E.C. Waaijer et al.   EXPERIMENTAL GERONTOLOGY

Vascular ageing: Underlying mechanisms and clinical implications

(2017) Ageliki Laina et al.   EXPERIMENTAL GERONTOLOGY

Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

(2017) Tomasz J. Guzik et al.   HYPERTENSION

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myocardial aging as a T-cell–mediated phenomenon

(2017) Gustavo Campos Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

(2016) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Age-associated vascular inflammation promotes monocytosis during atherogenesis

(2016) Wei Du et al.   AGING CELL

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Inflammatory processes in cardiovascular disease: a route to targeted therapies

(2016) Neil Ruparelia et al.   Nature Reviews Cardiology

The role of inflammation in age-related disease

(2016) T. Kevin Howcroft et al.   Aging-US

Loss of Nfkb1 leads to early onset aging

(2016) Giovanna M. Bernal et al.   Aging-US

Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization

(2015) Hiroe Toba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Passive leg movement and nitric oxide-mediated vascular function: the impact of age

(2015) Joel D. Trinity et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

(2015) David Goldeck et al.   BIOGERONTOLOGY

Mitochondrial sirtuins: Emerging roles in metabolic regulations, energy homeostasis and diseases

(2015) Priyanka Parihar et al.   EXPERIMENTAL GERONTOLOGY

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes and ageing-induced vascular inflammation

(2015) Mariam El Assar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition

(2015) Didier. Rémond et al.   Oncotarget

Age-dependent variation in cytokines, chemokines and biologic analytes rinsed from the surface of healthy human skin

(2015) Patrick M. Kinn et al.   Scientific Reports

The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs

(2015) Fiorella Ghisays et al.   Cell Reports

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

(2015) Yasumichi Arai et al.   EBioMedicine

The Influence of Age and Gender on Skin-Associated Microbial Communities in Urban and Rural Human Populations

(2015) Shi Ying et al.   PLoS One

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

(2014) D. Grahame Hardie   Annual Review of Nutrition

Arterial stiffness and influences of the metabolic syndrome: A cross-countries study

(2014) Angelo Scuteri et al.   ATHEROSCLEROSIS

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aging and the Burden of Multimorbidity: Associations With Inflammatory and Anabolic Hormonal Biomarkers

(2014) Elisa Fabbri et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Reprint of: A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study

(2014) Agnes Berendsen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice

(2014) HUAN GONG et al.   Molecular Medicine Reports

Correction: Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2014) Elena Biagi et al.   PLoS One

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Aging of the Nitric Oxide System: Are We as Old as Our NO?

(2014) Aaron L. Sverdlov et al.   Journal of the American Heart Association

The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure

(2014) Svend A. Mortensen et al.   JACC-Heart Failure

Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway

(2013) Ming-liang Chen et al.   Autophagy

Ageing-induced decrease in cardiac mitochondrial function in healthy rats

(2013) Oana M. Duicu et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation

(2013) Arie J. Hoogendijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

(2013) Julia Brenmoehl et al.   MITOCHONDRION

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen–glucose deprivation/reperfusion

(2012) Jiabin Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The aging gut microbiota: New perspectives

(2011) Elena Biagi et al.   AGEING RESEARCH REVIEWS

Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

(2011) Bradley S. Fleenor et al.   AGING CELL

Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis

(2011) Brendon J. Gurd   Applied Physiology Nutrition and Metabolism

17β-Estradiol, Aging, Inflammation, and the Stress Response in the Female Heart

(2011) James P. Stice et al.   ENDOCRINOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Nitric Oxide-Induced Activation of the AMP-Activated Protein Kinase α2 Subunit Attenuates IκB Kinase Activity and Inflammatory Responses in Endothelial Cells

(2011) Elke Bess et al.   PLoS One

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells

(2009) A. Peairs et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Persistent Impairment of Endothelial Vasomotor Function Has a Negative Impact on Outcome in Patients With Coronary Artery Disease

(2009) Yoshinobu Kitta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogenic control of mitochondrial function and biogenesis

(2008) Carolyn M. Klinge   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles

(2007) Michael D. Delp et al.   JOURNAL OF PHYSIOLOGY-LONDON