mtDNA Heteroplasmy at the Core of Aging-Associated Heart Failure. An Integrative View of OXPHOS and Mitochondrial Life Cycle in Cardiac Mitochondrial Physiology

Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging

(2020) Ruizhu Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

(2020) Qian Cai et al.   Cells

DNA damage invokes mitophagy through a pathway involving Spata18

(2020) Xiuli Dan et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging

(2020) Yue Quan et al.   Oxidative Medicine and Cellular Longevity

Mitophagy in Cardiovascular Diseases

(2020) Giampaolo Morciano et al.   Journal of Clinical Medicine

MitophAging: Mitophagy in Aging and Disease

(2020) Daniela Bakula et al.   Frontiers in Cell and Developmental Biology

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

(2020) Beverly Y. Mok et al.   NATURE

Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1

(2020) Woo Hyun Shin et al.   Cell Death & Disease

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons

(2020) Manoj Kumar et al.   Stem Cell Reports

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

(2020) José A. Nicolás-Ávila et al.   CELL

Mitochondrial DNA in extracellular vesicles declines with age

(2020) Stephanie Lazo et al.   AGING CELL

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

(2020) Huiliang Zhang et al.   eLife

Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics

(2020) Alvaro M. Gonzalez-Ibanez et al.   Frontiers in Cell and Developmental Biology

Mitochondrial genetic haplogroups and cardiovascular diseases: Data from the Osteoarthritis Initiative

(2019) Nicola Veronese et al.   PLoS One

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles

(2019) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation

(2019) Mark A. Lampert et al.   Autophagy

The mutation m.13513G>A impairs cardiac function, favoring a neuroectoderm commitment, in a mutant‐load dependent way

(2019) Teresa Galera‐Monge et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy

(2019) Bereketeab Haileselassie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial DNA and cardiovascular diseases: A long road ahead

(2019) Roberto Elosua   European Journal of Preventive Cardiology

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Mitochondrial MsrB2 serves as a switch and transducer for mitophagy

(2019) Seung Hee Lee et al.   EMBO Molecular Medicine

Morphological Stages of Mitochondrial Vacuolar Degeneration in Phenylephrine-Stressed Cardiac Myocytes and in Animal Models and Human Heart Failure

(2019) Antoine H. Chaanine   Medicina-Lithuania

Autophagy regulates lipid metabolism through selective turnover of NCoR1

(2019) Tetsuya Saito et al.   Nature Communications

Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury

(2019) Stefanie Marek-Iannucci et al.   Scientific Reports

Mitochondrial DNA Variants and Common Diseases: A Mathematical Model for the Diversity of Age-Related mtDNA Mutations

(2019) Huanzheng Li et al.   Cells

Nuclear receptor corepressor 1 represses cardiac hypertrophy

(2019) Chao Li et al.   EMBO Molecular Medicine

Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging

(2019) Ne N. Wu et al.   Oxidative Medicine and Cellular Longevity

Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury

(2019) Shi-Jing Wang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

FKBP8 LIRL‐dependent mitochondrial fragmentation facilitates mitophagy under stress conditions

(2019) Seung‐Min Yoo et al.   FASEB JOURNAL

Mitochondrial therapy promotes regeneration of injured hippocampal neurons

(2018) Ling Chien et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

(2018) Yuxiao Sun et al.   CIRCULATION

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

TA-65, A Telomerase Activator, Improves Cardiovascular Markers in Patients with Metabolic Syndrome

(2018) Maria Luz Fernandez et al.   CURRENT PHARMACEUTICAL DESIGN

Altered Extracellular Vesicle Concentration, Cargo and Function in Diabetes Mellitus

(2018) David W. Freeman et al.   DIABETES

Anti-apoptosis in nonmyocytes and pro-autophagy in cardiomyocytes: two strategies against postinfarction heart failure through regulation of cell death/degeneration

(2018) Genzou Takemura et al.   HEART FAILURE REVIEWS

Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice

(2018) Qing Ou-Yang et al.   HEPATOLOGY

Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy

(2018) Shuyi Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Gene therapy for the mitochondrial genome: Purging mutations, pacifying ailments

(2018) M. Aravintha Siva et al.   MITOCHONDRION

Mouse cardiac mitochondria do not separate in subsarcolemmal and interfibrillar subpopulations

(2018) Ulrike B. Hendgen-Cotta et al.   MITOCHONDRION

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

(2018) Evan Graehl Williams et al.   MOLECULAR & CELLULAR PROTEOMICS

Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link

(2018) Yukun Zhang et al.   Oxidative Medicine and Cellular Longevity

Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function

(2018) Mi Jin Kim et al.   Scientific Reports

Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals

(2018) Lakshmi Narayanan Lakshmanan et al.   AGING CELL

3-D electron microscopy techniques for unravelling mitochondrial dysfunction in heart failure and identification of new pharmacological targets

(2018) Hussam M Daghistani et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy

(2018) Meagan J. McManus et al.   Cell Metabolism

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease

(2018) E. Sandra Chocron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease

(2017) Christopher A. Sinkler et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

(2017) Verónica Eisner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening

(2017) Hao Zhou et al.   Journal of the American Heart Association

Association of Mitochondrial DNA Copy Number With Cardiovascular Disease

(2017) Foram N. Ashar et al.   JAMA Cardiology

Pioglitazone increases PGC1-α signaling within chronically ischemic myocardium

(2016) Tammy A. Butterick et al.   BASIC RESEARCH IN CARDIOLOGY

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

Modifying the Mitochondrial Genome

(2016) Alexander N. Patananan et al.   Cell Metabolism

Assessing Cardiac Metabolism

(2016) Heinrich Taegtmeyer et al.   CIRCULATION RESEARCH

Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region

(2016) Viktor M. Pastukh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Receptor-mediated mitophagy

(2016) Osamu Yamaguchi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitophagy plays a central role in mitochondrial ageing

(2016) Alan Diot et al.   MAMMALIAN GENOME

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

(2016) Yujia Yuan et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

The architecture of respiratory supercomplexes

(2016) James A. Letts et al.   NATURE

Mitochondria targeting nano agents in cancer therapeutics

(2016) Xiao-Ying Zhang et al.   Oncology Letters

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

(2016) Nikolay P. Kandul et al.   Nature Communications

Functional asymmetry and electron flow in the bovine respirasome

(2016) Joana S Sousa et al.   eLife

The receptor proteins: pivotal roles in selective autophagy

(2015) Zhijie Xu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts

(2015) Jon Sin et al.   Autophagy

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

(2015) K Palikaras et al.   CELL DEATH AND DIFFERENTIATION

O-GlcNAcomic Profiling Identifies WidespreadO-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function

(2015) Junfeng Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Mitochondrial Genome Editing by CRISPR/Cas9

(2015) Areum Jo et al.   Biomed Research International

Complex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal Muscle

(2015) Barbara Kupr et al.   Frontiers in Physiology

Internalization of isolated functional mitochondria: involvement of macropinocytosis

(2014) Tomoya Kitani et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ketogenic diets, mitochondria, and neurological diseases

(2014) Lindsey B. Gano et al.   JOURNAL OF LIPID RESEARCH

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

(2014) Jina Yun et al.   eLife

The role of mitochondrial function and cellular bioenergetics in ageing and disease

(2013) M.D. Brand et al.   BRITISH JOURNAL OF DERMATOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Localization of exogenous DNA to mitochondria in skeletal muscle following hydrodynamic limb vein injection

(2013) Yukari Yasuzaki et al.   JOURNAL OF CONTROLLED RELEASE

Road to exercise mimetics: targeting nuclear receptors in skeletal muscle

(2013) Weiwei Fan et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup

(2013) Kevin A. Strauss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kissing and nanotunneling mediate intermitochondrial communication in the heart

(2013) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Transcriptional Repression of Mitochondrial Function in Aging: A Novel Role for the Silencing Mediator of Retinoid and Thyroid Hormone Receptors Co-Repressor

(2012) Sihao Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria in Control of Cell Fate

(2012) Clifford D.L. Folmes et al.   CIRCULATION RESEARCH

Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management

(2012) M. G. D. Bates et al.   EUROPEAN HEART JOURNAL

Targeting nucleic acids into mitochondria: Progress and prospects

(2012) Adnan Khan Niazi et al.   MITOCHONDRION

The Corepressor NCoR1 Antagonizes PGC-1  and Estrogen-Related Receptor   in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

(2012) J. Perez-Schindler et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Transferring isolated mitochondria into tissue culture cells

(2012) Yi-Wei Yang et al.   NUCLEIC ACIDS RESEARCH

miR-484 regulates mitochondrial network through targeting Fis1

(2012) Kun Wang et al.   Nature Communications

The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation

(2011) Jennifer R. Hom et al.   DEVELOPMENTAL CELL

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Superresolution Fluorescence Imaging of Mitochondrial Nucleoids Reveals Their Spatial Range, Limits, and Membrane Interaction

(2011) T. A. Brown et al.   MOLECULAR AND CELLULAR BIOLOGY

Detecting Heteroplasmy from High-Throughput Sequencing of Complete Human Mitochondrial DNA Genomes

(2010) Mingkun Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction

(2010) Ryota Iwasawa et al.   EMBO JOURNAL

Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population

(2010) Yutaka Nishigaki et al.   Geriatrics & Gerontology International

Mitochondrial biogenesis in cold-bodied fishes

(2010) K. M. O'Brien   JOURNAL OF EXPERIMENTAL BIOLOGY

Mitochondrial fission/fusion dynamics and apoptosis

(2010) Clare Sheridan et al.   MITOCHONDRION

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort

(2010) Anita Lakatos et al.   NEUROBIOLOGY OF AGING

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

(2009) Judith Haendeler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Lack of functional assembly in mitochondrial supercomplexes: a new insight into impaired mitochondrial function?

(2008) F. J. Garcia-Palmer   CARDIOVASCULAR RESEARCH

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The coming acceleration of global population ageing

(2008) Wolfgang Lutz et al.   NATURE

The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging

(2007) A HIONA   EXPERIMENTAL GERONTOLOGY