Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target
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Title
Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-11-19
DOI
10.3389/fphar.2019.01360
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Note: Only part of the references are listed.- Lactofermented Annurca Apple Puree as a Functional Food Indicated for the Control of Plasma Lipid and Oxidative Amine Levels: Results from a Randomised Clinical Trial
- (2019) Gian Tenore et al. Nutrients
- Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults
- (2019) Melissa Erickson et al. Nutrients
- Urinary Levels of Trimethylamine‐N‐Oxide and Incident Coronary Heart Disease: A Prospective Investigation Among Urban Chinese Adults
- (2019) Danxia Yu et al. Journal of the American Heart Association
- Differential Effect of Short-Term Popular Diets on TMAO and Other Cardio-metabolic Risk Markers
- (2019) Ji Eun Park et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Targeted metabolomic analysis of plasma metabolites in patients with coronary heart disease in southern China
- (2019) Zhixiong Zhong et al. MEDICINE
- Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice
- (2019) Vienna E. Brunt et al. JOURNAL OF PHYSIOLOGY-LONDON
- Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndromes
- (2019) Xinmin S Li et al. EUROPEAN HEART JOURNAL
- Trimethylamine N-oxide promotes tissue factor expression and activity in vascular endothelial cells: A new link between trimethylamine N-oxide and atherosclerotic thrombosis
- (2019) Xiaoye Cheng et al. THROMBOSIS RESEARCH
- Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3 ) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels—Brief Report
- (2019) Diana M. Shih et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Regulation of circadian rhythms by NEAT1 mediated TMAO-induced endothelial proliferation: A protective role of asparagus extract
- (2019) Xiaoyue Wu et al. EXPERIMENTAL CELL RESEARCH
- Trimethylamine-N-oxide, as a risk factor for atherosclerosis, induces stress in J774A.1 murine macrophages
- (2018) Abbas Mohammadi et al. Advances in Medical Sciences
- Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes
- (2018) Arash Haghikia et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway
- (2018) Jin Geng et al. BIOMEDICINE & PHARMACOTHERAPY
- The Role of Microbiota in Cardiovascular Risk: Focus on Trimethylamine Oxide
- (2018) Hussein Al-Rubaye et al. CURRENT PROBLEMS IN CARDIOLOGY
- Enterococcus faecium WEFA23 from infant lessens high-fat-diet-induced hyperlipidemia via cholesterol 7-alpha-hydroxylase gene by altering the composition of gut microbiota in rats
- (2018) Fuqing Huang et al. JOURNAL OF DAIRY SCIENCE
- Gut Microbial-related Choline Metabolite Trimethylamine-N-oxide is Associated with Progression of Carotid Artery Atherosclerosis in HIV Infection
- (2018) Zhilei Shan et al. JOURNAL OF INFECTIOUS DISEASES
- Trigonelline inhibits intestinal microbial metabolism of choline and its associated cardiovascular risk
- (2018) Siraj Anwar et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk
- (2018) W. Zhu et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Chronic exposure to fungicide propamocarb induces bile acid metabolic disorder and increases trimethylamine in C57BL/6J mice
- (2018) Sisheng Wu et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Lactobacillus plantarum ZDY04 exhibits strain-specific property of lowering-TMAO via modulation of gut microbiota in mice
- (2018) Liang Qiu et al. Food & Function
- Mediterranean Diet Score: Associations with Metabolic Products of the Intestinal Microbiome, Carotid Plaque Burden, and Renal Function
- (2018) Michael Pignanelli et al. Nutrients
- Diet for stroke prevention
- (2018) J David Spence JOURNAL OF INVESTIGATIVE MEDICINE
- Heat shock proteins and cardiovascular disease
- (2018) B Rodríguez-Iturbe et al. Physiology International
- Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice
- (2018) Yafei Shi et al. BIOMEDICINE & PHARMACOTHERAPY
- The Association between Plasma Levels of Trimethylamine N-Oxide and the Risk of Coronary Heart Disease in Chinese Patients with or without Type 2 Diabetes Mellitus
- (2018) Zengxiang Dong et al. DISEASE MARKERS
- Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
- (2018) Adam B. Roberts et al. NATURE MEDICINE
- Lifestyle Intervention Decreases Urine Trimethylamine N -Oxide Levels in Prepubertal Children with Obesity
- (2018) María Jesús Leal-Witt et al. Obesity
- Gut Colonization with Methanogenic Archaea Lowers Plasma Trimethylamine N-oxide Concentrations in Apolipoprotein e−/− Mice
- (2018) Ali Ramezani et al. Scientific Reports
- The Role of Gut Microbiota in Atherosclerosis and Hypertension
- (2018) Junli Ma et al. Frontiers in Pharmacology
- Relation of Circulating Trimethylamine N-Oxide With Coronary Atherosclerotic Burden in Patients With ST-segment Elevation Myocardial Infarction
- (2018) Zhaoxue Sheng et al. AMERICAN JOURNAL OF CARDIOLOGY
- L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women
- (2018) Joanna J. Samulak et al. ANNALS OF NUTRITION AND METABOLISM
- Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation
- (2018) Takami Sho et al. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
- Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential
- (2018) Sarah M. Skye et al. CIRCULATION RESEARCH
- Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women
- (2018) Zeneng Wang et al. EUROPEAN HEART JOURNAL
- Guggulsterone, a farnesoid X receptor antagonist lowers plasma trimethylamine-N-oxide levels: An evidence from in vitro and in vivo studies
- (2018) A Gautam et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis
- (2018) Aliia R. Fatkhullina et al. IMMUNITY
- l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
- (2018) Robert A. Koeth et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeted inhibition of gut microbiota proteins involved in TMAO production to reduce platelet aggregation and arterial thrombosis: a blueprint for drugging the microbiota in the treatment of cardiometabolic disease?
- (2018) T. E. Mens et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Homocysteine accelerates atherosclerosis via inhibiting LXRα–mediated ABCA1/ABCG1–dependent cholesterol efflux from macrophages
- (2018) Ping Jin et al. LIFE SCIENCES
- Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
- (2018) Lin Ding et al. Lipids in Health and Disease
- Trimethylamine N-oxide (TMAO), Mediterranean Diet and Nutrition in Healthy, Normal-weight Subjects: Is It Also A Matter Of Gender?
- (2018) Luigi Barrea et al. NUTRITION
- Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target
- (2018) Manuel Janeiro et al. Nutrients
- Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors
- (2017) Xinmin S. Li et al. EUROPEAN HEART JOURNAL
- NLRP3 inflammasome: Its regulation and involvement in atherosclerosis
- (2017) Zahra Hoseini et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice
- (2017) Renqing Wang et al. LABORATORY INVESTIGATION
- Effect of long-term dietary sphingomyelin supplementation on atherosclerosis in mice
- (2017) Rosanna W. S. Chung et al. PLoS One
- Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies
- (2017) Katie Meyer et al. Nutrients
- Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway
- (2017) Ming‐liang Chen et al. Journal of the American Heart Association
- Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice
- (2017) Kui Chen et al. Frontiers in Physiology
- Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress
- (2017) Tiejun Li et al. Frontiers in Physiology
- Uncovering the trimethylamine-producing bacteria of the human gut microbiota
- (2017) Silke Rath et al. Microbiome
- Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice
- (2017) Paul M. Ryan et al. Microbiome
- The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
- (2016) Karolina Skagen et al. ATHEROSCLEROSIS
- L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP
- (2016) Heidi L. Collins et al. ATHEROSCLEROSIS
- Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome
- (2016) Xiaolei Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
- (2016) Weifei Zhu et al. CELL
- Trimethylamine N -oxide and Risk Stratification after Acute Myocardial Infarction
- (2016) Toru Suzuki et al. CLINICAL CHEMISTRY
- Atherosclerosis and aortic aneurysm - is inflammation a common denominator?
- (2016) Iuliia O. Peshkova et al. FEBS Journal
- Simultaneous targeted analysis of trimethylamine-N-oxide, choline, betaine, and carnitine by high performance liquid chromatography tandem mass spectrometry
- (2016) Jia Liu et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Role of gut microbiota in atherosclerosis
- (2016) Annika Lindskog Jonsson et al. Nature Reviews Cardiology
- Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
- (2016) Ming-liang Chen et al. mBio
- Intestinal Microbiota‐Generated Metabolite Trimethylamine‐N‐Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE‐Like Patient Cohort
- (2016) Vichai Senthong et al. Journal of the American Heart Association
- Microbiota‐Dependent Metabolite Trimethylamine N‐Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)
- (2016) Katie A. Meyer et al. Journal of the American Heart Association
- Trimethylamine N ‐Oxide and Mortality Risk in Patients With Peripheral Artery Disease
- (2016) Vichai Senthong et al. Journal of the American Heart Association
- Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
- (2016) Marcus M. Seldin et al. Journal of the American Heart Association
- Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults
- (2016) Yu-ming Chen et al. Scientific Reports
- Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans
- (2016) Elko Randrianarisoa et al. Scientific Reports
- Effect of Lactobacillus casei Shirota supplementation on trimethylamine-N-oxide levels in patients with metabolic syndrome: An open-label, randomized study
- (2015) Norbert J. Tripolt et al. ATHEROSCLEROSIS
- Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control
- (2015) Daniel M. Mueller et al. ATHEROSCLEROSIS
- Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
- (2015) Zeneng Wang et al. CELL
- Emerging roles of flavin monooxygenase 3 in cholesterol metabolism and atherosclerosis
- (2015) Rebecca C. Schugar et al. CURRENT OPINION IN LIPIDOLOGY
- High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome
- (2015) Francesca De Filippis et al. GUT
- Plasma Concentrations of Trimethylamine-N-oxide Are Directly Associated with Dairy Food Consumption and Low-Grade Inflammation in a German Adult Population
- (2015) Sabine Rohrmann et al. JOURNAL OF NUTRITION
- Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis
- (2015) George A. Kaysen et al. JOURNAL OF RENAL NUTRITION
- Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden
- (2015) J. R. Stubbs et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Short-term high-fat diet increases postprandial trimethylamine- N -oxide in humans
- (2015) Nabil E. Boutagy et al. NUTRITION RESEARCH
- Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet
- (2015) Nabil E. Boutagy et al. Obesity
- Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide
- (2015) Kymberleigh A. Romano et al. mBio
- Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
- (2015) Ji Miao et al. Nature Communications
- The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance
- (2015) Manya Warrier et al. Cell Reports
- Role of gut microbiota in the modulation of atherosclerosis-associated immune response
- (2015) Dmitry A. Chistiakov et al. Frontiers in Microbiology
- Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack
- (2015) Jia Yin et al. Journal of the American Heart Association
- Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry
- (2014) Zeneng Wang et al. ANALYTICAL BIOCHEMISTRY
- Role of the Microbiota in Immunity and Inflammation
- (2014) Yasmine Belkaid et al. CELL
- γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO
- (2014) Robert A. Koeth et al. Cell Metabolism
- Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
- (2014) Z. Wang et al. EUROPEAN HEART JOURNAL
- Perspectives: The burden of cardiovascular risk factors and coronary heart disease in Europe and worldwide
- (2014) G. Vilahur et al. EUROPEAN HEART JOURNAL SUPPLEMENTS
- NLRP3 Inflammasome as a Novel Player in Myocardial Infarction
- (2014) Masafumi Takahashi International Heart Journal
- Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation
- (2014) Jill C. Gregory et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The contributory role of gut microbiota in cardiovascular disease
- (2014) W.H. Wilson Tang et al. JOURNAL OF CLINICAL INVESTIGATION
- Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
- (2014) Diana M. Shih et al. JOURNAL OF LIPID RESEARCH
- Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure
- (2014) W.H. Wilson Tang et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation
- (2014) Janis Kuka et al. LIFE SCIENCES
- Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
- (2014) Xiaoting Wang et al. NATURE
- The role of heat shock proteins in atherosclerosis
- (2014) Georg Wick et al. Nature Reviews Cardiology
- Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
- (2013) Brian J. Bennett et al. Cell Metabolism
- Meat-Loving Microbes
- (2013) Jane F. Ferguson Circulation-Cardiovascular Genetics
- The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts
- (2013) Giuseppe Maiolino et al. MEDIATORS OF INFLAMMATION
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
- (2013) Ramón Estruch et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
- (2013) W.H. Wilson Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- TXNIP shuttling: missing link between oxidative stress and inflammasome activation
- (2013) Troy Lane et al. Frontiers in Physiology
- Atherosclerosis as an Inflammatory Disease
- (2012) Antonino Tuttolomondo et al. CURRENT PHARMACEUTICAL DESIGN
- Antibiotics in early life alter the murine colonic microbiome and adiposity
- (2012) Ilseung Cho et al. NATURE
- Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport
- (2011) Lin Jia et al. Annual Review of Physiology
- NF-κB, Inflammation, and Metabolic Disease
- (2011) Rebecca G. Baker et al. Cell Metabolism
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
- (2011) Zeneng Wang et al. NATURE
- The Sterile Inflammatory Response
- (2010) Kenneth L. Rock et al. Annual Review of Immunology
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- Pattern Recognition Receptors and Inflammation
- (2010) Osamu Takeuchi et al. CELL
- Major Dietary Protein Sources and Risk of Coronary Heart Disease in Women
- (2010) Adam M. Bernstein et al. CIRCULATION
- Choline and betaine in health and disease
- (2010) Per Magne Ueland JOURNAL OF INHERITED METABOLIC DISEASE
- Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
- (2010) Sofia Buonocore et al. NATURE
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
- (2009) Rongbin Zhou et al. NATURE IMMUNOLOGY
- Choline: an essential nutrient for public health
- (2009) Steven H Zeisel et al. NUTRITION REVIEWS
- Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
- (2009) Philippe Lefebvre et al. PHYSIOLOGICAL REVIEWS
- Atherosclerosis—An immune disease
- (2008) Göran K. Hansson ATHEROSCLEROSIS
- A Specific CD36-Dependent Signaling Pathway Is Required for Platelet Activation by Oxidized Low-Density Lipoprotein
- (2008) Kan Chen et al. CIRCULATION RESEARCH
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