Mitochondria-Targeted Drug Delivery in Cardiovascular Disease: A Long Road to Nano-Cardio Medicine

MitoQ regulates redox-related non-coding RNAs to preserve mitochondrial network integrity in pressure overload heart failure

(2020) Seulhee Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effect of ciclosporin on safety, lymphocyte kinetics and left ventricular remodelling in acute myocardial infarction

(2020) Suzanne Cormack et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

STVNa Attenuates Isoproterenol-Induced Cardiac Hypertrophy Response through the HDAC4 and Prdx2/ROS/Trx1 Pathways

(2020) Fei Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Elamipretide on Left Ventricular Function in Patients with Heart Failure with Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial

(2020) Javed Butler et al.   JOURNAL OF CARDIAC FAILURE

Structure-activity Relationships Study of Isothiocyanates for H2S Releasing Properties: 3-Pyridyl-Isothiocyanate as a New Promising Cardioprotective Agent

(2020) Valentina Citi et al.   Journal of Advanced Research

The roles of resveratrol on cardiac mitochondrial function in cardiac diseases

(2020) Apiwan Arinno et al.   EUROPEAN JOURNAL OF NUTRITION

No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial

(2020) Marlies de Ligt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC‐1α pathway

(2020) Ying Mei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial protein interaction landscape of SS-31

(2020) Juan D. Chavez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Validation of Gene Therapy for Mutant Mitochondria by Delivering Mitochondrial RNA Using a MITO-Porter

(2020) Eriko Kawamura et al.   Molecular Therapy-Nucleic Acids

Mitochondria in acute myocardial infarction and cardioprotection

(2020) Chrishan J.A. Ramachandra et al.   EBioMedicine

Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases

(2020) Zhibei Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

(2020) Xing Chang et al.   Oxidative Medicine and Cellular Longevity

Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury

(2020) Arihide Okahara et al.   Scientific Reports

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury

(2019) Sean M. Davidson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondria-targeted antioxidant delivery for precise treatment of myocardial ischemia–reperfusion injurythrough a multistage continuous targeted strategy

(2019) Ying Cheng et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice

(2019) Kah Yong Goh et al.   Redox Biology

Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

(2019) Chang-xiong Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion

(2019) Ting Cao et al.   BASIC RESEARCH IN CARDIOLOGY

Resveratrol and Vascular Function

(2019) Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Supplementing preservation solution with mitochondria‐targeted H 2 S donor AP39 protects cardiac grafts from prolonged cold ischemia reperfusion injury in heart transplantation

(2019) Cuilin Zhu et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Protective Effects of Euthyroidism Restoration on Mitochondria Function and Quality Control in Cardiac Pathophysiology

(2019) Francesca Forini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function

(2019) Omar Lozano et al.   Oxidative Medicine and Cellular Longevity

Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes

(2019) Di Liu et al.   BIOMATERIALS

Impaired NF-κB signalling underlies cyclophilin D-mediated mitochondrial permeability transition pore opening in doxorubicin cardiomyopathy

(2019) Rimpy Dhingra et al.   CARDIOVASCULAR RESEARCH

Identification of an ATP-sensitive potassium channel in mitochondria

(2019) Angela Paggio et al.   NATURE

Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury

(2019) Danchen Wu et al.   FASEB JOURNAL

Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice

(2019) Shan Gao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats

(2018) Linan Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart FailureNovelty and Significance

(2018) Swati Dey et al.   CIRCULATION RESEARCH

Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes

(2018) Mahsa Gholami et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Triphenylphosphonium and D-α-tocopheryl polyethylene glycol 1000 succinate-modified, tanshinone IIA-loaded lipid-polymeric nanocarriers for the targeted therapy of myocardial infarction

(2018) Shouwen Zhang et al.   International Journal of Nanomedicine

Mitochondrial transgene expression via an artificial mitochondrial DNA vector in cells from a patient with a mitochondrial disease

(2018) Takuya Ishikawa et al.   JOURNAL OF CONTROLLED RELEASE

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK

(2018) Yuuki Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway

(2018) Jia Qi et al.   Frontiers in Pharmacology

The role of CD44, hyaluronan and NHE1 in cardiac remodeling

(2018) Muna Suleiman et al.   LIFE SCIENCES

Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II

(2018) Dan Wu et al.   Redox Biology

Health Effects of Resveratrol: Results from Human Intervention Trials

(2018) Sonia Ramírez-Garza et al.   Nutrients

Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

(2018) Michał Wiciński et al.   Nutrients

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

(2018) Amjad Khan et al.   Frontiers in Pharmacology

SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM

(2018) Pankaj Bagul et al.   Cells

Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol

(2017) Lara Testai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore

(2017) Sung Ho Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury

(2017) Chayodom Maneechote et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Protective effect of quercetin on homocysteine-induced oxidative stress

(2017) Naime Çelik et al.   NUTRITION

Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome

(2017) Evgeni Yu. Zernii et al.   Oxidative Medicine and Cellular Longevity

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation

(2016) Junhui Sun et al.   CARDIOVASCULAR RESEARCH

A mitochondria-targeted antioxidant can inhibit peroxidase activity of cytochromecby detachment of the protein from liposomes

(2016) Alexander M. Firsov et al.   FEBS LETTERS

Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy

(2016) Rui Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis

(2016) Ying Gao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cyclosporine A in Reperfused Myocardial Infarction

(2016) Filippo Ottani et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro

(2016) Domokos Gerő et al.   PHARMACOLOGICAL RESEARCH

The novel H 2 S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoK ATP channels and reduction of oxidative stress

(2016) Lara Testai et al.   PHARMACOLOGICAL RESEARCH

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

(2016) Ayako Ishikita et al.   Journal of the American Heart Association

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction

(2016) Euy‐Myoung Jeong et al.   Journal of the American Heart Association

Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

(2016) Maria‐Corina Serban et al.   Journal of the American Heart Association

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening

(2016) Gentaro Ikeda et al.   Scientific Reports

Rationale and design of the Cyclosporine to ImpRove Clinical oUtcome in ST-elevation myocardial infarction patients (the CIRCUS trial)

(2015) Nathan Mewton et al.   AMERICAN HEART JOURNAL

CoQ10 Function and Role in Heart Failure and Ischemic Heart Disease

(2015) Anita Ayer et al.   Annual Review of Nutrition

Antioxidants in Translational Medicine

(2015) Harald H.H.W. Schmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial delivery of antisense RNA by MITO-Porter results in mitochondrial RNA knockdown, and has a functional impact on mitochondria

(2015) Ryo Furukawa et al.   BIOMATERIALS

Hybrid poly(lactic-co-glycolic acid) nanoparticles: design and delivery prospectives

(2015) Deepti Pandita et al.   DRUG DISCOVERY TODAY

EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention

(2015) C. Michael Gibson et al.   EUROPEAN HEART JOURNAL

Mitochondria as Key Targets of Cardioprotection in Cardiac Ischemic Disease: Role of Thyroid Hormone Triiodothyronine

(2015) Francesca Forini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model

(2015) Anna J. Dare et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice

(2015) Kohei Ikeda et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress

(2014) Suman Dalal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cyclosporine Protects the Heart during Aortic Valve Surgery

(2014) Pascal Chiari et al.   ANESTHESIOLOGY

The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning

(2014) Ioanna Andreadou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative Post-Translational Modifications Develop LONP1 Dysfunction in Pressure Overload Heart Failure

(2014) Atsushi Hoshino et al.   Circulation-Heart Failure

Mitochondria selectiveS-nitrosation by mitochondria-targetedS-nitrosothiol protects against post-infarct heart failure in mouse hearts

(2014) Carmen Methner et al.   EUROPEAN JOURNAL OF HEART FAILURE

CD44 Is Critically Involved in Infarct Healing by Regulating the Inflammatory and Fibrotic Response

(2014) P. Huebener et al.   JOURNAL OF IMMUNOLOGY

The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure

(2014) Svend A. Mortensen et al.   JACC-Heart Failure

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

(2013) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE

(2013) C. Penna et al.   BASIC RESEARCH IN CARDIOLOGY

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death

(2013) Ali A. Sovari et al.   Circulation-Arrhythmia and Electrophysiology

Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides

(2013) Dao-Fu Dai et al.   Circulation-Heart Failure

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia

(2013) David A. Brown et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

(2013) Min Luo et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Pharmacological characterization of the vascular effects of aryl isothiocyanates: Is hydrogen sulfide the real player?

(2013) Alma Martelli et al.   VASCULAR PHARMACOLOGY

Adverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Mellitus–Related Endothelial Dysfunction in Humans

(2012) Tinoy J. Kizhakekuttu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial division/mitophagy inhibitor (Mdivi) Ameliorates Pressure Overload Induced Heart Failure

(2012) Srikanth Givvimani et al.   PLoS One

Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria‐Targeting Cytoprotective Peptide

(2012) Robert A. Kloner et al.   Journal of the American Heart Association

Resolution of Mitochondrial Oxidative Stress Rescues Coronary Collateral Growth in Zucker Obese Fatty Rats

(2011) Yuh Fen Pung et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent

(2011) DJ Hausenloy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Identification of S-nitrosated mitochondrial proteins byS-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation

(2010) Edward T. Chouchani et al.   BIOCHEMICAL JOURNAL

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Effects of vitamins C and E and β-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial

(2009) Yiqing Song et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke)

(2009) L. E. Bakeeva et al.   BIOCHEMISTRY-MOSCOW

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies

(2009) Y. N. Antonenko et al.   BIOCHEMISTRY-MOSCOW

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

(2009) T. A. Prime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamins E and C in the Prevention of Cardiovascular Disease in Men

(2008) Howard D. Sesso   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stevioside and related compounds: Therapeutic benefits beyond sweetness

(2008) Varanuj Chatsudthipong et al.   PHARMACOLOGY & THERAPEUTICS

Do Mitochondriotropic Antioxidants Prevent Chlorinative Stress-Induced Mitochondrial and Cellular Injury?

(2007) Matthew Whiteman et al.   ANTIOXIDANTS & REDOX SIGNALING

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

(2007) Yuma Yamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES