The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome

The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease

(2021) David C. Hondius et al.   ACTA NEUROPATHOLOGICA

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

(2021) Ryan A. Neff et al.   Science Advances

Sequence of proteome profiles in preclinical and symptomatic Alzheimer's disease

(2021) Xiaohang Li et al.   Alzheimers & Dementia

Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

(2021) Joseph C. Roney et al.   DEVELOPMENTAL CELL

Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics

(2021) B.C. Carlyle et al.   NEUROBIOLOGY OF AGING

Alzheimer disease

(2021) David S. Knopman et al.   Nature Reviews Disease Primers

Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies

(2021) Guiqin Chen et al.   Science Advances

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

(2020) Bing Bai et al.   NEURON

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

(2020) Satoshi Muraoka et al.   Alzheimers & Dementia

27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer’s Disease

(2020) Zhen Wang et al.   ANALYTICAL CHEMISTRY

Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of Alcadein α-deficient mice

(2020) Naoya Gotoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease

(2020) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

(2020) Aliza P. Wingo et al.   NATURE NEUROSCIENCE

APOE-amyloid interaction: Therapeutic targets

(2020) Thomas Wisniewski et al.   NEUROBIOLOGY OF DISEASE

SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer’s Disease Mouse Model

(2020) Soo Yong Park et al.   Cells

Quantitative proteomic analysis of the frontal cortex in Alzheimer’s disease

(2020) Gajanan Sathe et al.   JOURNAL OF NEUROCHEMISTRY

Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease

(2020) Hong Wang et al.   Molecular Neurodegeneration

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

(2020) Sathish Kumar et al.   Acta Neuropathologica Communications

Molecular abnormalities in autopsied brain tissue from the inferior horn of the lateral ventricles of nonagenarians and Alzheimer disease patients

(2020) Andrew Pearson et al.   BMC Neurology

Phosphorylated tau interactome in the human Alzheimer’s disease brain

(2020) Eleanor Drummond et al.   BRAIN

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

(2020) Magdalene K. Montgomery et al.   Science Translational Medicine

Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease

(2020) Lingyan Ping et al.   Scientific Data

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease

(2020) Lenora Higginbotham et al.   Science Advances

Late-onset vs nonmendelian early-onset Alzheimer disease

(2020) Christiane Reitz et al.   Neurology-Genetics

Inclusion of African American/Black adults in a pilot brain proteomics study of Alzheimer's disease

(2020) Kaitlyn E. Stepler et al.   NEUROBIOLOGY OF DISEASE

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

(2020) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques

(2020) Tadafumi Hashimoto et al.   Acta Neuropathologica Communications

Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease

(2019) Feng Xiong et al.   Alzheimers & Dementia

Proteomic Atlas of the Human Brain in Alzheimer’s Disease

(2019) Justin McKetney et al.   JOURNAL OF PROTEOME RESEARCH

V232M substitution restricts a distinct O-glycosylation of PLD3 and its neuroprotective function

(2019) Atanas Vladimirov Demirev et al.   NEUROBIOLOGY OF DISEASE

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease

(2019) Hazal Haytural et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease

(2019) Clarissa Ferolla Mendonça et al.   NEUROBIOLOGY OF DISEASE

Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies

(2019) Geoffrey Pires et al.   Acta Neuropathologica Communications

Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease

(2018) David M. A. Mann et al.   ACTA NEUROPATHOLOGICA

Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition

(2018) Ann D. Cohen et al.   Alzheimers & Dementia

Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing

(2018) Aamir S. Mukadam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus

(2018) Sofia Hassiotis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Generation and Partial Characterization of Rabbit Monoclonal Antibody to Pyroglutamate Amyloid-β3-42 (pE3-Aβ)

(2018) Pankaj D. Mehta et al.   JOURNAL OF ALZHEIMERS DISEASE

Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain

(2018) Santiago Solé-Domènech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunotherapy to improve cognition and reduce pathological species in an Alzheimer’s disease mouse model

(2018) Krystal Herline et al.   Alzheimers Research & Therapy

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

(2018) David C. Hondius et al.   Acta Neuropathologica Communications

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease

(2018) Qi Zhang et al.   Acta Neuropathologica Communications

The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

(2018) Yvonne S. Davidson et al.   Acta Neuropathologica Communications

High-Affinity Rabbit Monoclonal Antibodies Specific for Amyloid Peptides Amyloid-β40 and Amyloid-β42

(2018) David L. Miller et al.   JOURNAL OF ALZHEIMERS DISEASE

Clusterin contributes to early stage of Alzheimer's disease pathogenesis

(2018) Shin-Bi Oh et al.   BRAIN PATHOLOGY

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

(2018) Erik C. B. Johnson et al.   Molecular Neurodegeneration

Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

(2018) Jingting Dai et al.   Frontiers in Molecular Neuroscience

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

(2018) Melanie Hüttenrauch et al.   Acta Neuropathologica Communications

Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer’s Disease

(2017) Li Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies

(2017) Mitsuru Shinohara et al.   JOURNAL OF LIPID RESEARCH

BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon

(2017) Ginny G. Farías et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

(2017) Nicholas T. Seyfried et al.   Cell Systems

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

(2016) David C. Hondius et al.   Alzheimers & Dementia

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer’s Disease

(2016) Patricia R. Spilman et al.   JOURNAL OF ALZHEIMERS DISEASE

Dementia in Down's syndrome

(2016) Clive Ballard et al.   LANCET NEUROLOGY

Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease

(2016) Robert A. Sweet et al.   MOLECULAR & CELLULAR PROTEOMICS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression

(2016) Chadwick M. Hales et al.   PROTEOMICS

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

(2015) Mark L. Cohen et al.   BRAIN

Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis

(2015) Khader Awwad et al.   CARDIOVASCULAR RESEARCH

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage

(2015) Yasuhiro Teranishi et al.   FEBS Journal

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

(2015) Willem Kamphuis et al.   GLIA

Dickkopf-related protein 3 is a potential Aβ-associated protein in Alzheimer's Disease

(2015) Kim A. Bruggink et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic analysis of neurons microdissected from formalin-fixed, paraffin-embedded Alzheimer’s disease brain tissue

(2015) Eleanor S Drummond et al.   Scientific Reports

Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease

(2015) Jae Ho Kim et al.   Scientific Reports

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

Quantification of the Brain Proteome in Alzheimer’s Disease Using Multiplexed Mass Spectrometry

(2014) Sravani Musunuri et al.   JOURNAL OF PROTEOME RESEARCH

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques

(2014) Anna Pensalfini et al.   NEUROBIOLOGY OF DISEASE

PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains

(2014) Jun-ichi Satoh et al.   Alzheimers Research & Therapy

Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models

(2013) Jeffrey L. Frost et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Secretory Sorting Receptors Carboxypeptidase E and Secretogranin III in Amyloid β-Associated Neural Degeneration in Alzheimer's Disease

(2012) Virginia Plá et al.   BRAIN PATHOLOGY

Ezrin/Radixin/Moesin Are Required for the Purinergic P2X7 Receptor (P2X7R)-dependent Processing of the Amyloid Precursor Protein

(2012) Amaria Darmellah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains

(2012) Victor P. Andreev et al.   JOURNAL OF PROTEOME RESEARCH

F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice

(2012) D.M. Hafez et al.   NEUROSCIENCE

Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease

(2012) Laura E. Donovan et al.   Proteomics Clinical Applications

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Changes in Brain β-Amyloid Deposition and Aquaporin 4 Levels in Response to AlteredAgrinExpression in Mice

(2011) Steven M. Rauch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

SMOC1 Is Essential for Ocular and Limb Development in Humans and Mice

(2010) Ippei Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease

(2009) R.-M. Liu et al.   NEUROBIOLOGY OF AGING

COL25A1 triggers and promotes Alzheimer’s disease-like pathology in vivo

(2009) Ying Tong et al.   NEUROGENETICS

Enhanced clearance of A  in brain by sustaining the plasmin proteolysis cascade

(2008) J. S. Jacobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA