Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

(2017) Chia-Chen Liu et al.   JOURNAL OF NEUROSCIENCE

Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology

(2017) Stuart Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

(2017) Laura B. Jaeger et al.   JOURNAL OF ALZHEIMERS DISEASE

Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aβ and LRP1 in Hippocampus

(2016) Xin Wang et al.   Evidence-based Complementary and Alternative Medicine

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

(2016) Masaya Tachibana et al.   EXPERIMENTAL NEUROLOGY

Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

(2016) Yuan Fu et al.   Molecular Neurodegeneration

Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease

(2016) Ileana Soto et al.   NEUROBIOLOGY OF AGING

A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease

(2016) Kaitlin M. Moore et al.   NEUROBIOLOGY OF DISEASE

Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta

(2016) Masashi Kitazawa et al.   TOXICOLOGICAL SCIENCES

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

(2015) Pietra Candela et al.   BRAIN RESEARCH

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway

(2015) Caroline S. Casey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

(2015) C.-C. Liu et al.   JOURNAL OF NEUROSCIENCE

ApoE4 and A  Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation

(2015) A. Sen et al.   JOURNAL OF NEUROSCIENCE

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

(2015) Manasi Malik et al.   Molecular Neurodegeneration

Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice

(2015) Tzu-Wei Lin et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Antisense RNA Controls LRP1 Sense Transcript Expression through Interaction with a Chromatin-Associated Protein, HMGB2

(2015) Yasunari Yamanaka et al.   Cell Reports

Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer’s disease

(2014) Mitsuru Shinohara et al.   BRAIN

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo

(2014) Moran Gilat-Frenkel et al.   Current Alzheimer Research

NMDA Neurotransmission Dysfunction in Mild Cognitive Impairment and Alzheimer’s Disease

(2014) Chieh-Hsin Lin et al.   CURRENT PHARMACEUTICAL DESIGN

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

The role of choroid plexus in IVIG-induced beta-amyloid clearance

(2014) H. Gu et al.   NEUROSCIENCE

Mechanisms of U87 Astrocytoma Cell Uptake and Trafficking of Monomeric versus Protofibril Alzheimer’s Disease Amyloid-β Proteins

(2014) Yali Li et al.   PLoS One

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Regulates the Stability and Function of GluA1 α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (AMPA) Receptor in Neurons

(2014) Ming Gan et al.   PLoS One

Possible modification of Alzheimer’s disease by statins in midlife: interactions with genetic and non-genetic risk factors

(2014) Mitsuru Shinohara et al.   Frontiers in Aging Neuroscience

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo

(2014) Timo Grimmer et al.   NeuroImage-Clinical

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation

(2013) Mitsuru Shinohara et al.   ACTA NEUROPATHOLOGICA

LDL Receptor–Related Protein-1

(2013) Steven L. Gonias et al.   AMERICAN JOURNAL OF PATHOLOGY

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

(2013) Simon J. Henderson et al.   BRAIN

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) ModulatesN-Methyl-d-aspartate (NMDA) Receptor-dependent Intracellular Signaling and NMDA-induced Regulation of Postsynaptic Protein Complexes

(2013) Chikako Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Lipoprotein Receptor Cluster IV Mutant Preferentially Binds Amyloid-β and Regulates Its Clearance from the Mouse Brain

(2013) Abhay P. Sagare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1

(2013) Jo V. Rushworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis

(2013) Hua Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Enhanced Proteolytic Clearance of Plasma A  by Peripherally Administered Neprilysin Does Not Result in Reduced Levels of Brain A  in Mice

(2013) J. R. Walker et al.   JOURNAL OF NEUROSCIENCE

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex

(2013) G. A. Rodriguez et al.   LEARNING & MEMORY

Role of the cannabinoid system in the transit of beta-amyloid across the blood–brain barrier

(2013) Corbin Bachmeier et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype

(2013) Wladislaw Maier et al.   Molecular Neurodegeneration

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

The LDL Receptor-Related Protein 1 (LRP1) Regulates the PDGF Signaling Pathway by Binding the Protein Phosphatase SHP-2 and Modulating SHP-2- Mediated PDGF Signaling Events

(2013) Julie Craig et al.   PLoS One

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine

(2012) Michelle A. Erickson et al.   BRAIN BEHAVIOR AND IMMUNITY

Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cϵ

(2012) Abhik Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: Relationship to cerebral amyloid angiopathy and APOE status

(2012) Wan Adriyani W. Ruzali et al.   NEUROSCIENCE LETTERS

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease

(2012) Carlos Spuch et al.   Frontiers in Physiology

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease

(2011) Harshvardhan Rolyan et al.   JOURNAL OF NEURAL TRANSMISSION

Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier

(2011) Masachika Fujiyoshi et al.   JOURNAL OF NEUROCHEMISTRY

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Association of ApoE and LRP mRNA levels with dementia and AD neuropathology

(2011) Afia Akram et al.   NEUROBIOLOGY OF AGING

Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

(2011) Qiang Liu et al.   PLOS BIOLOGY

Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer’s disease

(2010) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1

(2010) Bjoern von Einem et al.   EXPERIMENTAL NEUROLOGY

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

(2010) Joshua B. Owen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Forms a Signaling Complex with Platelet-derived Growth Factor Receptor-β in Endosomes and Regulates Activation of the MAPK Pathway

(2010) Selen Catania Muratoglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

(2010) Y. Andrews-Zwilling et al.   JOURNAL OF NEUROSCIENCE

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Up-regulation of hepatic low-density lipoprotein receptor–related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl–coenzyme A reductase inhibitor

(2010) Jae Hoon Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

(2010) Thorsten Pflanzner et al.   NEUROBIOLOGY OF AGING

Genetic Interaction between Tau and the Apolipoprotein E Receptor LRP1 Increases Alzheimer’s Disease Risk

(2009) José Luis Vázquez-Higuera et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese

(2009) Yong M. Shi et al.   INTERNATIONAL PSYCHOGERIATRICS

Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease

(2009) Yoichiro Nishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Density Lipoprotein Receptor-related Protein 1 Promotes Anti-apoptotic Signaling in Neurons by Activating Akt Survival Pathway

(2009) Rodrigo A. Fuentealba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease

(2009) Rukhsana Sultana et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

APOE  2 is associated with intact cognition but increased Alzheimer pathology in the oldest old

(2009) D. J. Berlau et al.   NEUROLOGY

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid β Peptides in anin VitroModel of the Blood-Brain Barrier Cells

(2008) Kaoru Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

(2008) Robert D. Bell et al.   NATURE CELL BIOLOGY

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

(2008) Babak Nazer et al.   NEUROBIOLOGY OF DISEASE

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

 -Secretase Limits the Inflammatory Response Through the Processing of LRP1

(2008) K. Zurhove et al.   Science Signaling

Environmental Enrichment Counteracts Alzheimer’s Neurovascular Dysfunction in TgCRND8 Mice

(2007) Arne Herring et al.   BRAIN PATHOLOGY