Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

Apolipoprotein E, Receptors, and Modulation of Alzheimer’s Disease

(2018) Na Zhao et al.   BIOLOGICAL PSYCHIATRY

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

(2018) Chengzhong Wang et al.   NATURE MEDICINE

Tau Kinetics in Neurons and the Human Central Nervous System

(2018) Chihiro Sato et al.   NEURON

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

(2018) Zeran Li et al.   Genome Medicine

Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease

(2018) Lingyan Ping et al.   Scientific Data

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

(2018) Erik C. B. Johnson et al.   Molecular Neurodegeneration

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load

(2017) Michel J. Grothe et al.   NEUROLOGY

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

(2017) Nicholas T. Seyfried et al.   Cell Systems

The role of APOE in cerebrovascular dysfunction

(2016) Leon M. Tai et al.   ACTA NEUROPATHOLOGICA

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

(2015) Thomas G. Beach et al.   NEUROPATHOLOGY

FastRFunctions for Robust Correlations and Hierarchical Clustering

(2015) Peter Langfelder et al.   Journal of Statistical Software

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

Digital sorting of complex tissues for cell type-specific gene expression profiles

(2013) Yi Zhong et al.   BMC BIOINFORMATICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis

(2013) S. Schilling et al.   NEUROLOGY

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Genes and pathways underlying regional and cell type changes in Alzheimer's disease

(2013) Jeremy A Miller et al.   Genome Medicine

Normalization and missing value imputation for label-free LC-MS analysis

(2012) Yuliya V Karpievitch et al.   BMC BIOINFORMATICS

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Volume of white matter hyperintensities in healthy adults: Contribution of age, vascular risk factors, and inflammation-related genetic variants

(2011) Naftali Raz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study

(2011) Alessandro Biffi et al.   LANCET NEUROLOGY

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Variants at APOE influence risk of deep and lobar intracerebral hemorrhage

(2010) Alessandro Biffi et al.   ANNALS OF NEUROLOGY

Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells

(2010) Christian A. Luber et al.   IMMUNITY

Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

(2010) Yadong Huang   TRENDS IN MOLECULAR MEDICINE

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

APOE  2 is associated with intact cognition but increased Alzheimer pathology in the oldest old

(2009) D. J. Berlau et al.   NEUROLOGY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Functional organization of the transcriptome in human brain

(2008) Michael C Oldham et al.   NATURE NEUROSCIENCE