Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression

Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)

(2017) Richard J. O'Brien et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of frailty with the serine protease HtrA1 in older adults

(2016) Maria Lorenzi et al.   EXPERIMENTAL GERONTOLOGY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity

(2015) Malte Butzlaff et al.   HUMAN MOLECULAR GENETICS

Expression of Regulatory Proteins in Choroid Plexus Changes in Early Stages of Alzheimer Disease

(2015) Agnieszka Krzyzanowska et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alzheimer's Aβ interacts with cellular prion protein inducing neuronal membrane damage and synaptotoxicity

(2015) Christian Peters et al.   NEUROBIOLOGY OF AGING

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

FastRFunctions for Robust Correlations and Hierarchical Clustering

(2015) Peter Langfelder et al.   Journal of Statistical Software

Aggregates of Small Nuclear Ribonucleic Acids (snRNAs) in Alzheimer's Disease

(2014) Chadwick M. Hales et al.   BRAIN PATHOLOGY

Aggregation Properties of the Small Nuclear Ribonucleoprotein U1-70K in Alzheimer Disease

(2014) Ian Diner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders

(2014) Song-Yu Yang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

(2014) Chadwick M Hales et al.   Molecular Neurodegeneration

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

(2014) Andrew A. Sproul et al.   PLoS One

Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

(2014) J. Giustiniani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins

(2014) Eric B. Dammer et al.   PROTEOMICS

Proteomics of protein post-translational modifications implicated in neurodegeneration

(2014) Ru-Jing Ren et al.   Translational Neurodegeneration

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

(2013) J. M. Shulman et al.   HUMAN MOLECULAR GENETICS

Membrane-Anchored A  Accelerates Amyloid Formation and Exacerbates Amyloid-Associated Toxicity in Mice

(2013) A. Nagarathinam et al.   JOURNAL OF NEUROSCIENCE

Neuron Enriched Nuclear Proteome Isolated from Human Brain

(2013) Eric B. Dammer et al.   JOURNAL OF PROTEOME RESEARCH

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

(2013) B. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease

(2013) Laura E Donovan et al.   Alzheimers Research & Therapy

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Evaluation of annexin A5 as a biomarker for Alzheimer's disease and dementia with lewy bodies

(2013) Hitoshi Sohma et al.   Frontiers in Aging Neuroscience

GO-Elite: a flexible solution for pathway and ontology over-representation

(2012) Alexander C. Zambon et al.   BIOINFORMATICS

Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates

(2012) Annette Tennstaedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PAFAH1B2 Reduces Amyloid-  Generation by Promoting the Degradation of Amyloid Precursor Protein C-Terminal Fragments

(2012) R. M. Page et al.   JOURNAL OF NEUROSCIENCE

Quantitative Analysis of the Detergent-Insoluble Brain Proteome in Frontotemporal Lobar Degeneration Using SILAC Internal Standards

(2012) Nicholas T. Seyfried et al.   JOURNAL OF PROTEOME RESEARCH

Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination

(2012) Eric B. Dammer et al.   PLoS One

Asparaginyl endopeptidase cleaves TDP-43 in brain

(2012) Jeremy H. Herskowitz et al.   PROTEOMICS

Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease

(2012) Laura E. Donovan et al.   Proteomics Clinical Applications

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

A yeast functional screen predicts new candidate ALS disease genes

(2011) J. Couthouis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematical Optimization of Reverse-Phase Chromatography for Shotgun Proteomics

(2009) Ping Xu et al.   JOURNAL OF PROTEOME RESEARCH

Proteomics Analysis Reveals Novel Components in the Detergent-Insoluble Subproteome in Alzheimer’s Disease

(2009) Yair M. Gozal et al.   JOURNAL OF PROTEOME RESEARCH

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

(2008) Bradford C. Dickerson et al.   CEREBRAL CORTEX

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE