Lysosomes and lysosome‐related organelles in immune responses

Why TAPBPR? Implications of an additional player in MHC class I peptide presentation

(2021) Ida Hafstrand et al.   CURRENT OPINION IN IMMUNOLOGY

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

(2021) Fernando Y Maeda et al.   eLife

Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells

(2021) Sabrina Sofia Burgener et al.   Frontiers in Cell and Developmental Biology

Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2

(2020) Thomas Ostendorf et al.   IMMUNITY

Cross-presentation of exogenous antigens on MHC I molecules

(2020) Jeff D Colbert et al.   CURRENT OPINION IN IMMUNOLOGY

How Lysosomes Sense, Integrate, and Cope with Stress

(2020) Paul Saftig et al.   TRENDS IN BIOCHEMICAL SCIENCES

The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens

(2020) Johnathan Canton et al.   NATURE IMMUNOLOGY

Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity

(2020) Mateja Prunk et al.   Cancers

Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

(2019) Dali Han et al.   NATURE

The road to lysosome‐related organelles: Insights from Hermansky‐Pudlak syndrome and other rare diseases

(2019) Shanna L. Bowman et al.   TRAFFIC

Proteasomal degradation within endocytic organelles mediates antigen cross‐presentation

(2019) Debrup Sengupta et al.   EMBO JOURNAL

The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells

(2019) Juan José Sáez et al.   JOURNAL OF CELL BIOLOGY

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

The Lysosome Signaling Platform: Adapting With the Times

(2019) Subothan Inpanathan et al.   Frontiers in Cell and Developmental Biology

Lysosome-related organelles as functional adaptations of the endolysosomal system

(2019) Cédric Delevoye et al.   CURRENT OPINION IN CELL BIOLOGY

B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments

(2019) Sara Hernández-Pérez et al.   JOURNAL OF CELL SCIENCE

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms controlling nucleic acid-sensing Toll-like receptors

(2018) Kensuke Miyake et al.   INTERNATIONAL IMMUNOLOGY

The role of innate immunity in mucopolysaccharide diseases

(2018) Helen Parker et al.   JOURNAL OF NEUROCHEMISTRY

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

(2017) Tan A. Nguyen et al.   IMMUNITY

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

(2017) Jeff E. Grotzke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

(2017) Sophia Maschalidi et al.   Nature Communications

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

(2017) Paula Nunes-Hasler et al.   Nature Communications

The elucidation of non-classical MHC class II antigen processing through the study of viral antigens

(2017) Asha Purnima Veerappan Ganesan et al.   Current Opinion in Virology

Impairment of dendritic cell functions in patients with adaptor protein-3 complex deficiency

(2016) Alberto Prandini et al.   BLOOD

The melting pot of the MHC II peptidome

(2016) Lawrence J Stern et al.   CURRENT OPINION IN IMMUNOLOGY

Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis

(2016) Stephen P. Matthews et al.   IMMUNITY

Dendritic cell maturation and cross-presentation: timing matters!

(2016) Andrés Alloatti et al.   IMMUNOLOGICAL REVIEWS

The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity

(2016) Cristina C. Clement et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

(2016) Katelyn M. Spillane et al.   JOURNAL OF CELL BIOLOGY

The cytotoxic T lymphocyte immune synapse at a glance

(2016) Nele M. G. Dieckmann et al.   JOURNAL OF CELL SCIENCE

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

(2016) Xiaopeng Qi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome ProceedsViaHigh Specificity

(2016) Geert P. M. Mommen et al.   MOLECULAR & CELLULAR PROTEOMICS

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8

(2016) Hiromi Tanji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen Presentation to B Cells

(2016) Balthasar A. Heesters et al.   TRENDS IN IMMUNOLOGY

Lipid peroxidation causes endosomal antigen release for cross-presentation

(2016) Ilse Dingjan et al.   Scientific Reports

Modulation of antigen presentation by intracellular trafficking

(2015) Justine D Mintern et al.   CURRENT OPINION IN IMMUNOLOGY

Determinants of immunodominance for CD4 T cells

(2015) AeRyon Kim et al.   CURRENT OPINION IN IMMUNOLOGY

The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-Presentation to CD8+ T Cells

(2015) Matthias Zehner et al.   IMMUNITY

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

(2015) Andrés Alloatti et al.   IMMUNITY

Antigen-B Cell Receptor Complexes Associate with Intracellular major histocompatibility complex (MHC) Class II Molecules

(2015) Margarida Barroso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

(2015) Sei Yoshida et al.   JOURNAL OF CELL BIOLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways

(2015) Mohammad Samie et al.   NATURE IMMUNOLOGY

Endogenous antigen processing drives the primary CD4+ T cell response to influenza

(2015) Michael A Miller et al.   NATURE MEDICINE

DNase II-dependent DNA digestion is required for DNA sensing by TLR9

(2015) Mei Po Chan et al.   Nature Communications

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

(2015) Mélanie Chabaud et al.   Nature Communications

TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation

(2014) Priyanka Nair-Gupta et al.   CELL

The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production

(2014) Toshihiko Kobayashi et al.   IMMUNITY

Dendritic Cells Treated with Lipopolysaccharide Up-Regulate Serine Protease Inhibitor 6 and Remain Sensitive to Killing by Cytotoxic T Lymphocytes In Vivo

(2014) K. A. Andrew et al.   JOURNAL OF IMMUNOLOGY

Endosomal Localization of TLR8 Confers Distinctive Proteolytic Processing on Human Myeloid Cells

(2014) Noriko Ishii et al.   JOURNAL OF IMMUNOLOGY

The MHC Class II Cofactor HLA-DM Interacts with Ig in B Cells

(2014) Henriette Macmillan et al.   JOURNAL OF IMMUNOLOGY

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

(2014) Norihiro Nakamura et al.   NATURE

Damage control: cellular mechanisms of plasma membrane repair

(2014) Norma W. Andrews et al.   TRENDS IN CELL BIOLOGY

Going Forward with Genetics

(2013) Eva Marie Y. Moresco et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation

(2013) Elizabeth D Mellins et al.   CURRENT OPINION IN IMMUNOLOGY

Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes

(2013) Madeleine M. Hipp et al.   IMMUNITY

Expanding roles for GILT in immunity

(2012) Laura Ciaccia West et al.   CURRENT OPINION IN IMMUNOLOGY

Adaptor Protein-3 in Dendritic Cells Facilitates Phagosomal Toll-like Receptor Signaling and Antigen Presentation to CD4+ T Cells

(2012) Adriana R. Mantegazza et al.   IMMUNITY

Serpinb9 (Spi6)-deficient mice are impaired in dendritic cell-mediated antigen cross-presentation

(2012) Alexandra Rizzitelli et al.   IMMUNOLOGY AND CELL BIOLOGY

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

(2012) Janna Schneppenheim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serine Protease Inhibitor 6 Is Required To Protect Dendritic Cells from the Kiss of Death

(2012) E. Lovo et al.   JOURNAL OF IMMUNOLOGY

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in the regulation of pathogen replication and adaptive immunity

(2012) Felix Randow et al.   TRENDS IN IMMUNOLOGY

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

(2012) Sophia Maschalidi et al.   PLoS Pathogens

The endosome–lysosome pathway and information generation in the immune system

(2011) Colin Watts   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells

(2011) Ignacio Cebrian et al.   CELL

Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner

(2011) Joanna M Rybicka et al.   EMBO JOURNAL

Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation

(2011) Maria-Isabel Yuseff et al.   IMMUNITY

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

(2010) Stephen P. Matthews et al.   JOURNAL OF IMMUNOLOGY

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

(2010) A. L. Blasius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

(2009) Fernando E. Sepulveda et al.   IMMUNITY

Involvement of the Toll-like receptor 4 pathway and use of TNF-  antagonists for treatment of the mucopolysaccharidoses

(2009) C. M. Simonaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

(2009) L. Saveanu et al.   SCIENCE

Glycosylation Directs Targeting and Activation of Cystatin F from Intracellular and Extracellular Sources

(2009) Jeff D Colbert et al.   TRAFFIC

Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

(2008) Garth Hamilton et al.   EMBO JOURNAL

TLR ligand–induced podosome disassembly in dendritic cells is ADAM17 dependent

(2008) Michele A. West et al.   JOURNAL OF CELL BIOLOGY

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

(2008) G. Faure-Andre et al.   SCIENCE

Migratory Dermal Dendritic Cells Act as Rapid Sensors of Protozoan Parasites

(2008) Lai Guan Ng et al.   PLoS Pathogens