Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

(2017) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Dendritic cell maturation and cross-presentation: timing matters!

(2016) Andrés Alloatti et al.   IMMUNOLOGICAL REVIEWS

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

(2016) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

(2016) Ludivine Baron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipid peroxidation causes endosomal antigen release for cross-presentation

(2016) Ilse Dingjan et al.   Scientific Reports

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-Presentation to CD8+ T Cells

(2015) Matthias Zehner et al.   IMMUNITY

Are ERAD components involved in cross-presentation?

(2015) Jeff E. Grotzke et al.   MOLECULAR IMMUNOLOGY

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Inhibitors of Protein Translocation Across the ER Membrane

(2015) Kai-Uwe Kalies et al.   TRAFFIC

Proteasome 19S RP Binding to the Sec61 Channel Plays a Key Role in ERAD

(2015) Marie-Luise Kaiser et al.   PLoS One

Key Steps in ERAD of Luminal ER Proteins Reconstituted with Purified Components

(2014) Alexander Stein et al.   CELL

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7

(2013) Thomas Tretter et al.   BMC CELL BIOLOGY

Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation

(2013) Jeff E. Grotzke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cells: Master Regulators of the Immune Response

(2013) I. Mellman   Cancer Immunology Research

Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

(2012) Eunyong Park et al.   Annual Review of Biophysics

Novel Murine Dendritic Cell Lines: A Powerful Auxiliary Tool for Dendritic Cell Research

(2012) Silvia A. Fuertes Marraco et al.   Frontiers in Immunology

Highly sensitive, operationally simple, cost/time effective detection of the mycolactones from the human pathogen Mycobacterium ulcerans

(2010) Thomas Spangenberg et al.   CHEMICAL COMMUNICATIONS

Intracellular mechanisms of antigen cross presentation in dendritic cells

(2010) Sebastian Amigorena et al.   CURRENT OPINION IN IMMUNOLOGY

A Role for Lipid Bodies in the Cross-presentation of Phagocytosed Antigens by MHC Class I in Dendritic Cells

(2009) Laurence Bougnères et al.   IMMUNITY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY