The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8−dendritic cells require the intramembrane endopeptidase SPPL2A

(2012) Hannes Bergmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

(2012) Daniel R. Beisner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

(2012) J. K. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L

(2011) Lalu Rudyat Telly Savalas et al.   BIOCHEMICAL JOURNAL

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

(2011) Jörg Behnke et al.   FEBS LETTERS

Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease

(2011) Robert C. Rickert et al.   IMMUNOLOGICAL REVIEWS

Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors

(2011) M. Kreuzaler et al.   JOURNAL OF IMMUNOLOGY

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Molecular characterisation of ‘transmembrane protein 192’ (TMEM192), a novel protein of the lysosomal membrane

(2010) Bernd Schröder et al.   BIOLOGICAL CHEMISTRY

B-cell targeted therapies in human autoimmune diseases: an updated perspective

(2010) Michael J. Townsend et al.   IMMUNOLOGICAL REVIEWS

Invariant chain increases the half-life of MHC II by delaying endosomal maturation

(2010) Ole J B Landsverk et al.   IMMUNOLOGY AND CELL BIOLOGY

Intramembrane Proteolysis

(2009) Michael S. Wolfe   CHEMICAL REVIEWS

B Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis

(2009) W. N. Khan   JOURNAL OF IMMUNOLOGY

B-cell-directed therapies for autoimmune disease

(2009) Thomas Dörner et al.   Nature Reviews Rheumatology

MHC II and the Endocytic Pathway: Regulation by Invariant Chain

(2009) O. J. B. Landsverk et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

(2008) A. De Gassart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA