Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

A Novel Size-Based Sorting Mechanism of Pinocytic Luminal Cargoes in Microglia

(2015) C. Chen et al.   JOURNAL OF NEUROSCIENCE

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Differential signaling during macropinocytosis in response to M-CSF and PMA in macrophages

(2015) Sei Yoshida et al.   Frontiers in Physiology

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dissecting the roles of Rac1 activation and deactivation in macropinocytosis using microscopic photo-manipulation

(2013) Makoto Fujii et al.   Scientific Reports

Rab5 Proteins Regulate Activation and Localization of Target of Rapamycin Complex 1

(2012) Dave Bridges et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

A growth factor signaling cascade confined to circular ruffles in macrophages

(2012) T. P. Welliver et al.   Biology Open

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

(2011) Stephen Jamieson et al.   BIOCHEMICAL JOURNAL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway

(2011) Sei Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ruffles limit diffusion in the plasma membrane during macropinosome formation

(2011) T. P. Welliver et al.   JOURNAL OF CELL SCIENCE

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

The biological and therapeutic relevance of mRNA translation in cancer

(2011) Sarah P. Blagden et al.   Nature Reviews Clinical Oncology

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Coordination of the Rab5 Cycle on Macropinosomes

(2011) William D. Feliciano et al.   TRAFFIC

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Regulation of mTORC1 by the Rab and Arf GTPases

(2010) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

The Late Endosome is Essential for mTORC1 Signaling

(2010) Rory J. Flinn et al.   MOLECULAR BIOLOGY OF THE CELL

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages

(2009) S. Yoshida et al.   JOURNAL OF CELL SCIENCE

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

A Unique Platform for H-Ras Signaling Involving Clathrin-independent Endocytosis

(2007) Natalie Porat-Shliom et al.   MOLECULAR BIOLOGY OF THE CELL