The cytotoxic T lymphocyte immune synapse at a glance

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis

(2016) Spencer A. Freeman et al.   CELL

Comparative Anatomy of Phagocytic and Immunological Synapses

(2016) Florence Niedergang et al.   Frontiers in Immunology

Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis

(2015) Jane C. Stinchcombe et al.   CURRENT BIOLOGY

Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders

(2015) Ellen Brisse et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

Centrin2 regulates CP110 removal in primary cilium formation

(2015) Suzanna L. Prosser et al.   JOURNAL OF CELL BIOLOGY

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

(2015) Misty R. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo

(2015) Omar I. Vivar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LYST Controls the Biogenesis of the Endosomal Compartment Required for Secretory Lysosome Function

(2015) Fernando E. Sepulveda et al.   TRAFFIC

Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes

(2015) Nele M.G. Dieckmann et al.   TRAFFIC

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses

(2014) Helena Soares et al.   IMMUNOLOGICAL REVIEWS

Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system

(2014) F. Finetti et al.   JOURNAL OF CELL SCIENCE

XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP

(2014) Stuart G Tangye   JOURNAL OF CLINICAL IMMUNOLOGY

Quantitative Phosphoproteomics of Cytotoxic T Cells to Reveal Protein Kinase D 2 Regulated Networks

(2014) María N. Navarro et al.   MOLECULAR & CELLULAR PROTEOMICS

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Serine-threonine kinases in TCR signaling

(2014) María N Navarro et al.   NATURE IMMUNOLOGY

Analysis of Familial Hemophagocytic Lymphohistiocytosis Type 4 (FHL-4) Mutant Proteins Reveals that S-Acylation Is Required for the Function of Syntaxin 11 in Natural Killer Cells

(2014) Andrew L. Hellewell et al.   PLoS One

Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naive CD8+ T cells

(2014) M. N. Navarro et al.   Science Signaling

Familial Hemophagocytic Lymphohistiocytosis: When Rare Diseases Shed Light on Immune System Functioning

(2014) Elena Sieni et al.   Frontiers in Immunology

Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes

(2013) Mahantappa Halimani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Centriole distal appendages promote membrane docking, leading to cilia initiation

(2013) B. E. Tanos et al.   GENES & DEVELOPMENT

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage

(2013) Jason Yi et al.   JOURNAL OF CELL BIOLOGY

Munc18-2 and Syntaxin 3 Control Distinct Essential Steps in Mast Cell Degranulation

(2013) C. Brochetta et al.   JOURNAL OF IMMUNOLOGY

Syntaxin binding mechanism and disease-causing mutations in Munc18-2

(2013) Y. Hackmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse

(2013) M. de la Roche et al.   SCIENCE

The function of sub-synaptic vesicles during T-cell activation

(2012) Marco A. Purbhoo   IMMUNOLOGICAL REVIEWS

The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane

(2011) E. D. Elstak et al.   BLOOD

Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane

(2011) Gayoung A. Han et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells

(2011) Emily J Quann et al.   NATURE IMMUNOLOGY

CD4+ T-cell synapses involve multiple distinct stages

(2011) H. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Enlarged Lysosomes in beigej Cells Result From Decreased Lysosome Fission and Not Increased Lysosome Fusion

(2011) Nina Durchfort et al.   TRAFFIC

Cytokine Secretion Is Distinct from Secretion of Cytotoxic Granules in NK Cells

(2010) E. Reefman et al.   JOURNAL OF IMMUNOLOGY

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

(2009) Francesca Finetti et al.   NATURE CELL BIOLOGY

Binding of the Munc13-1 MUN Domain to Membrane-Anchored SNARE Complexes†

(2008) Rong Guan et al.   BIOCHEMISTRY

Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils

(2008) Cristiana Brochetta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH