Molecular reporters for CRISPR/Cas: From design principles to engineering for bioanalytical and diagnostic applications

Functional nucleic acids in glycobiology: A versatile tool in the analysis of disease-related carbohydrates and glycoconjugates

(2022) Furong Zhao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

High-Fidelity CRISPR/Cas13a trans-Cleavage-Triggered Rolling Circle Amplified DNAzyme for Visual Profiling of MicroRNA

(2021) Ting Zhou et al.   ANALYTICAL CHEMISTRY

Reprogrammable Gel Electrophoresis Detection Assay Using CRISPR-Cas12a and Hybridization Chain Reaction

(2021) Mahera J. Kachwala et al.   ANALYTICAL CHEMISTRY

Synthesis of fluorescent nanoprobe with simultaneous response to intracellular pH and Zn2+ for tumor cell distinguishment

(2021) Qin Wang et al.   Microchimica Acta

Detection of SARS-CoV-2 and Its Mutated Variants via CRISPR-Cas13-Based Transcription Amplification

(2021) Yuxi Wang et al.   ANALYTICAL CHEMISTRY

Exploring the Trans-Cleavage Activity of CRISPR/Cas12a on Gold Nanoparticles for Stable and Sensitive Biosensing

(2021) Xiaoyi Fu et al.   ANALYTICAL CHEMISTRY

Signal-Amplified Detection of the Tumor Biomarker FEN1 Based on Cleavage-Induced Ligation of a Dumbbell DNA Probe and Rolling Circle Amplification

(2021) Bingzhi Li et al.   ANALYTICAL CHEMISTRY

Reverse Transcription Recombinase Polymerase Amplification Coupled with CRISPR-Cas12a for Facile and Highly Sensitive Colorimetric SARS-CoV-2 Detection

(2021) Wei S. Zhang et al.   ANALYTICAL CHEMISTRY

CRISPR‐Cas12a System for Biosensing and Gene Regulation

(2021) Yuyan Shi et al.   Chemistry-An Asian Journal

Development and application of a highly efficient CRISPR-Cas9 system for genome engineering in Bacillus megaterium

(2021) Philip Hartz et al.   JOURNAL OF BIOTECHNOLOGY

Enzyme-functionalized magnetic framework composite fabricated by one-pot encapsulation of lipase and Fe3O4 nanoparticle into metal–organic framework

(2021) Yuan Ji et al.   BIOCHEMICAL ENGINEERING JOURNAL

CRISPR-based detection of SARS-CoV-2: A review from sample to result

(2021) Reza Nouri et al.   BIOSENSORS & BIOELECTRONICS

An ultrasensitive CRISPR/Cas12a based electrochemical biosensor for Listeria monocytogenes detection

(2021) Fan Li et al.   BIOSENSORS & BIOELECTRONICS

Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor

(2021) Sarah Balderston et al.   Nature Biomedical Engineering

Amplification-free RNA detection with CRISPR–Cas13

(2021) Hajime Shinoda et al.   Communications Biology

An exonuclease protection and CRISPR/Cas12a integrated biosensor for the turn-on detection of transcription factors in cancer cells

(2021) Bingzhi Li et al.   ANALYTICA CHIMICA ACTA

Signal amplification and output of CRISPR/Cas-based biosensing systems: A review

(2021) Si-Yuan Wang et al.   ANALYTICA CHIMICA ACTA

Advancing sensing technology with CRISPR: From the detection of nucleic acids to a broad range of analytes – A review

(2021) Siying Xie et al.   ANALYTICA CHIMICA ACTA

CRISPR/Cas-Based In Vitro Diagnostic Platforms for Cancer Biomarker Detection

(2021) Shaohua Gong et al.   ANALYTICAL CHEMISTRY

G-triplex: A new type of CRISPR-Cas12a reporter enabling highly sensitive nucleic acid detection

(2021) Tao Li et al.   BIOSENSORS & BIOELECTRONICS

High-fidelity detection of DNA combining the CRISPR/Cas9 system and hairpin probe

(2021) Meng Wang et al.   BIOSENSORS & BIOELECTRONICS

Aptamer assisted CRISPR-Cas12a strategy for small molecule diagnostics

(2021) Chenqi Niu et al.   BIOSENSORS & BIOELECTRONICS

CRISPR/Cas Advancement in Molecular Diagnostics and Signal Readout Approaches

(2021) Md Z. Ahmed et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Droplet Cas12a Assay Enables DNA Quantification from Unamplified Samples at the Single-Molecule Level

(2021) Huahua Yue et al.   NANO LETTERS

Cas9-based RNA detection

(2021) Jie Wang   NATURE CELL BIOLOGY

Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins

(2021) Ning Jia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recognition of DNA Target Formulations by CRISPR-Cas12a Using a dsDNA Reporter

(2021) Christopher W. Smith et al.   ACS Synthetic Biology

Challenges and Opportunities for Clustered Regularly Interspaced Short Palindromic Repeats Based Molecular Biosensing

(2021) Mengdi Bao et al.   ACS Sensors

CRISPR-Cas12a-Powered Dual-Mode Biosensor for Ultrasensitive and Cross-validating Detection of Pathogenic Bacteria

(2021) Long Ma et al.   ACS Sensors

G-Quadruplex-Probing CRISPR-Cas12 Assay for Label-Free Analysis of Foodborne Pathogens and Their Colonization In Vivo

(2021) Xuhan Xia et al.   ACS Sensors

CRISPR as a Diagnostic Tool

(2021) Seohyun Kim et al.   Biomolecules

A chemical-enhanced system for CRISPR-Based nucleic acid detection

(2021) Zihan Li et al.   BIOSENSORS & BIOELECTRONICS

A CRISPR-based and post-amplification coupled SARS-CoV-2 detection with a portable evanescent wave biosensor

(2021) Yihan Yang et al.   BIOSENSORS & BIOELECTRONICS

CRISPR-Cas based virus detection: Recent advances and perspectives

(2021) Lijuan Yin et al.   BIOSENSORS & BIOELECTRONICS

Sensitive and rapid on-site detection of SARS-CoV-2 using a gold nanoparticle-based high-throughput platform coupled with CRISPR/Cas12-assisted RT-LAMP

(2021) Yaqin Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Universal and Naked-Eye Gene Detection Platform Based on the Clustered Regularly Interspaced Short Palindromic Repeats/Cas12a/13a System

(2020) Chaoqun Yuan et al.   ANALYTICAL CHEMISTRY

Armoring the Enzymes with Metal-Organic Frameworks

(2020) Siming Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-throughput and all-solution phase African Swine Fever Virus (ASFV) detection using CRISPR-Cas12a and fluorescence based point-of-care system

(2020) Qian He et al.   BIOSENSORS & BIOELECTRONICS

A signal transduction approach for multiplexed detection of transcription factors by integrating DNA nanotechnology, multi-channeled isothermal amplification, and chromatography

(2020) Yue Chen et al.   JOURNAL OF CHROMATOGRAPHY A

Single-Step, Salt-Aging-Free, and Thiol-Free Freezing Construction of AuNP-Based Bioprobes for Advancing CRISPR-Based Diagnostics

(2020) Menglu Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PAM recognition by miniature CRISPR–Cas12f nucleases triggers programmable double-stranded DNA target cleavage

(2020) Tautvydas Karvelis et al.   NUCLEIC ACIDS RESEARCH

Rapid and sensitive detection of COVID-19 using CRISPR/Cas12a-based detection with naked eye readout, CRISPR/Cas12a-NER

(2020) Xinjie Wang et al.   Science Bulletin

A One-Pot Toolbox Based on Cas12a/crRNA Enables Rapid Foodborne Pathogen Detection at Attomolar Level

(2020) Yunqing Wang et al.   ACS Sensors

CRISPR-dCas9 powered impedimetric biosensor for label-free detection of circulating tumor DNAs

(2020) Zihni Onur Uygun et al.   ANALYTICA CHIMICA ACTA

CRISPR Mediated Biosensing Toward Understanding Cellular Biology and Point‐of‐Care Diagnosis

(2020) Yifan Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An ultrasensitive and specific point-of-care CRISPR/Cas12 based lateral flow biosensor for the rapid detection of nucleic acids

(2020) Omar Mukama et al.   BIOSENSORS & BIOELECTRONICS

Multiple assays in a real-time RT-PCR SARS-CoV-2 panel can mitigate the risk of loss of sensitivity by new genomic variants during the COVID-19 outbreak

(2020) Luis Peñarrubia et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future

(2020) Fathema Uddin et al.   Frontiers in Oncology

A CRISPR-derived biosensor for the sensitive detection of transcription factors based on the target-induced inhibition of Cas12a activation

(2020) Bingzhi Li et al.   BIOSENSORS & BIOELECTRONICS

Point-of-care CRISPR/Cas nucleic acid detection: Recent advances, challenges and opportunities

(2020) Jeanne E. van Dongen et al.   BIOSENSORS & BIOELECTRONICS

Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing

(2020) Julia Joung et al.   NEW ENGLAND JOURNAL OF MEDICINE

iSCAN: An RT-LAMP-coupled CRISPR-Cas12 module for rapid, sensitive detection of SARS-CoV-2

(2020) Zahir Ali et al.   VIRUS RESEARCH

Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay

(2020) Xiong Ding et al.   Nature Communications

Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA

(2020) Maturada Patchsung et al.   Nature Biomedical Engineering

Clustered Regularly Interspaced Short Palindromic Repeats-Mediated Surface-Enhanced Raman Scattering Assay for Multidrug-Resistant Bacteria

(2020) Hongki Kim et al.   ACS Nano

A CRISPR-driven colorimetric code platform for highly accurate telomerase activity assay

(2020) Meng Cheng et al.   BIOSENSORS & BIOELECTRONICS

Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

(2020) Parinaz Fozouni et al.   CELL

CRISPR-based biosensing systems: a way to rapidly diagnose COVID-19

(2020) Majid Vatankhah et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

CRISPR-Cas12a-Based Nucleic Acid Amplification-Free DNA Biosensor via Au Nanoparticle-Assisted Metal-Enhanced Fluorescence and Colorimetric Analysis

(2020) Jin-Ha Choi et al.   NANO LETTERS

Digital CRISPR/Cas‐Assisted Assay for Rapid and Sensitive Detection of SARS‐CoV‐2

(2020) Joon Soo Park et al.   Advanced Science

Colorimetric Detection of SARS-CoV-2 and Drug-Resistant pH1N1 Using CRISPR/dCas9

(2020) Jeong Moon et al.   ACS Sensors

Ultrasensitive electrochemical assay for microRNA-21 based on CRISPR/Cas13a-assisted catalytic hairpin assembly

(2020) Ying Cui et al.   TALANTA

Rational design, synthesis, and applications of carbon dots@metal–organic frameworks (CD@MOF) based sensors

(2020) Bingzhi Li et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Versatile detection with CRISPR/Cas system from applications to challenges

(2020) Hui Wu et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

CRISPR/Cas Systems towards Next-Generation Biosensing

(2019) Yi Li et al.   TRENDS IN BIOTECHNOLOGY

Rapid and Fully Microfluidic Ebola Virus Detection with CRISPR-Cas13a

(2019) Peiwu Qin et al.   ACS Sensors

Colorimetric detection of nucleic acid sequences in plant pathogens based on CRISPR/Cas9 triggered signal amplification

(2019) Weidan Chang et al.   MICROCHIMICA ACTA

High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity

(2019) Yuanyue Shan et al.   ANALYTICAL CHEMISTRY

Detection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor

(2019) Reza Hajian et al.   Nature Biomedical Engineering

CRISPR-Cas14 is now part of the artillery for gene editing and molecular diagnostic

(2019) Guillermo Aquino-Jarquin   Nanomedicine-Nanotechnology Biology and Medicine

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9

(2019) Xing Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Naked-Eye Detection of Grapevine Red-Blotch Viral Infection Using a Plasmonic CRISPR Cas12a Assay

(2019) Yongya Li et al.   ANALYTICAL CHEMISTRY

Cas12aVDet: A CRISPR/Cas12a-Based Platform for Rapid and Visual Nucleic Acid Detection

(2019) Bei Wang et al.   ANALYTICAL CHEMISTRY

CRISPR-Cas12a Coupled with Platinum Nanoreporter for Visual Quantification of SNVs on a Volumetric Bar-Chart Chip

(2019) Ning Shao et al.   ANALYTICAL CHEMISTRY

Programmable CRISPR-responsive smart materials

(2019) Max A. English et al.   SCIENCE

Simultaneous determination of insulin and glucose in human serum based on dual emissive fluorescent nano-aptasensor of carbon dots and CdTe/CdS/ZnS quantum dots

(2019) Sohail Muhammad et al.   SENSORS AND ACTUATORS B-CHEMICAL

Visual detection of porcine reproductive and respiratory syndrome virus using CRISPR‐Cas13a

(2019) Yafei Chang et al.   Transboundary and Emerging Diseases

Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

(2019) Yifan Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CRISPR-Cas12a Nucleases Bind Flexible DNA Duplexes without RNA/DNA Complementarity

(2019) Wei Jiang et al.   ACS Omega

Rolling Circular Amplification (RCA)-Assisted CRISPR/Cas9 Cleavage (RACE) for Highly Specific Detection of Multiple Extracellular Vesicle MicroRNAs

(2019) Ruixuan Wang et al.   ANALYTICAL CHEMISTRY

A low-cost fluorescence reader for in vitro transcription and nucleic acid detection with Cas13a

(2019) Florian Katzmeier et al.   PLoS One

Cas12a-Based On-Site and Rapid Nucleic Acid Detection of African Swine Fever

(2019) Jing Bai et al.   Frontiers in Microbiology

Detection of target DNA with a novel Cas9/sgRNAs-associated reverse PCR (CARP) technique

(2018) Beibei Zhang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Triggered Isothermal Amplification for Site-Specific Nucleic Acid Detection

(2018) Mengqi Huang et al.   ANALYTICAL CHEMISTRY

Versatile High-Throughput Fluorescence Assay for Monitoring Cas9 Activity

(2018) Kyle J. Seamon et al.   ANALYTICAL CHEMISTRY

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

(2018) Shi-Yuan Li et al.   CELL RESEARCH

Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9

(2018) Austin T. Raper et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Field-deployable viral diagnostics using CRISPR-Cas13

(2018) Cameron Myhrvold et al.   SCIENCE

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

CRISPR/dCas9-mediated biosensor for detection of tick-borne diseases

(2018) Bonhan Koo et al.   SENSORS AND ACTUATORS B-CHEMICAL

Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing

(2018) Chengzu Long et al.   Science Advances

CRISPR-Cas12a-assisted nucleic acid detection

(2018) Shi-Yuan Li et al.   Cell Discovery

Detecting and typing target DNA with a novel CRISPR-typing PCR (ctPCR) technique

(2018) Beibei Zhang et al.   ANALYTICAL BIOCHEMISTRY

Direct Visualization of Single-Nucleotide Variation in mtDNA Using a CRISPR/Cas9-Mediated Proximity Ligation Assay

(2018) Kaixiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of widespread Type I and Type V CRISPR-Cas inhibitors

(2018) Nicole D. Marino et al.   SCIENCE

Functionally diverse type V CRISPR-Cas systems

(2018) Winston X. Yan et al.   SCIENCE

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

(2018) Lucas B. Harrington et al.   SCIENCE

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a

(2017) Daan C. Swarts et al.   MOLECULAR CELL

C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism

(2017) Liang Liu et al.   MOLECULAR CELL

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

(2017) Aaron A. Smargon et al.   MOLECULAR CELL

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes

(2017) Alexandra East-Seletsky et al.   MOLECULAR CELL

Erratum: Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

(2017) Stefano Stella et al.   NATURE

Diversity and evolution of class 2 CRISPR–Cas systems

(2017) Sergey Shmakov et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism of duplex DNA destabilization by RNA-guided Cas9 nuclease during target interrogation

(2017) Vladimir Mekler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Sensing telomerase: From in vitro detection to in vivo imaging

(2017) Li-juan Wang et al.   Chemical Science

The chemistry of Cas9 and its CRISPR colleagues

(2017) Janice S. Chen et al.   Nature Reviews Chemistry

In Vitro Evaluation of CRISPR/Cas9 Function by an Electrochemiluminescent Assay

(2016) Weipeng Liu et al.   ANALYTICAL CHEMISTRY

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

(2016) Takashi Yamano et al.   CELL

Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components

(2016) Keith Pardee et al.   CELL

PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease

(2016) Hui Yang et al.   CELL

Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition

(2016) Pu Gao et al.   CELL RESEARCH

The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA

(2016) Ines Fonfara et al.   NATURE

The crystal structure of Cpf1 in complex with CRISPR RNA

(2016) De Dong et al.   NATURE

New CRISPR–Cas systems from uncultivated microbes

(2016) David Burstein et al.   NATURE

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

(2016) Benjamin P Kleinstiver et al.   NATURE BIOTECHNOLOGY

Kinetics of the CRISPR-Cas9 effector complex assembly and the role of 3′-terminal segment of guide RNA

(2016) Vladimir Mekler et al.   NUCLEIC ACIDS RESEARCH

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

(2016) F. Jiang et al.   SCIENCE

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Cas9 cleavage assay for pre-screening of sgRNAs using nicking triggered isothermal amplification

(2016) Kaixiang Zhang et al.   Chemical Science

Paired Design of dCas9 as a Systematic Platform for the Detection of Featured Nucleic Acid Sequences in Pathogenic Strains

(2016) Yihao Zhang et al.   ACS Synthetic Biology

Crystal Structure of Staphylococcus aureus Cas9

(2015) Hiroshi Nishimasu et al.   CELL

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

CRISPR-Cas9: a new and promising player in gene therapy

(2015) Lu Xiao-Jie et al.   JOURNAL OF MEDICAL GENETICS

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

(2015) Sergey Shmakov et al.   MOLECULAR CELL

Conformational control of DNA target cleavage by CRISPR–Cas9

(2015) Samuel H. Sternberg et al.   NATURE

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

A Cas9-guide RNA complex preorganized for target DNA recognition

(2015) F. Jiang et al.   SCIENCE

Dynamics of CRISPR-Cas9 genome interrogation in living cells

(2015) Spencer C. Knight et al.   SCIENCE

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality

(2014) Alexandra E. Briner et al.   MOLECULAR CELL

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

(2014) John G Doench et al.   NATURE BIOTECHNOLOGY

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

(2014) M. Jinek et al.   SCIENCE

Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing

(2013) Vivek Anantharaman et al.   Biology Direct

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Real-time, label-free isothermal solid-phase amplification/detection (ISAD) device for rapid detection of genetic alteration in cancers

(2013) Yong Shin et al.   LAB ON A CHIP

CRISPR interference (CRISPRi) for sequence-specific control of gene expression

(2013) Matthew H Larson et al.   Nature Protocols

Gold nanoparticle-based signal amplification for biosensing

(2011) Xiaodong Cao et al.   ANALYTICAL BIOCHEMISTRY

Highly sensitive protein kinase activity assay based on electrochemiluminescence nanoprobes

(2011) Zhen Zhao et al.   BIOSENSORS & BIOELECTRONICS

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

(2011) Elitza Deltcheva et al.   NATURE