Signal-Amplified Detection of the Tumor Biomarker FEN1 Based on Cleavage-Induced Ligation of a Dumbbell DNA Probe and Rolling Circle Amplification

Protein‐Mediated Suppression of Rolling Circle Amplification for Biosensing with an Aptamer‐containing DNA Primer

(2020) John David Brennan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

(2020) Yingying Zhang et al.   DISEASE MARKERS

Sensitive detection of a bacterial pathogen using allosteric probe-initiated catalysis and CRISPR-Cas13a amplification reaction

(2020) Jinjin Shen et al.   Nature Communications

Determination of the concentration of transcription factor by using exonuclease III-aided amplification and gold nanoparticle mediated fluorescence intensity: A new method for gene transcription related enzyme detection

(2020) Kai Zhang et al.   ANALYTICA CHIMICA ACTA

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

(2020) Koen D. Flach et al.   CANCER RESEARCH

A signal transduction approach for multiplexed detection of transcription factors by integrating DNA nanotechnology, multi-channeled isothermal amplification, and chromatography

(2020) Yue Chen et al.   JOURNAL OF CHROMATOGRAPHY A

Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer

(2020) Xing Xin et al.   Frontiers in Oncology

DNA Nanotechnology: A Recent Advancement in the Monitoring of Microcystin-LR

(2020) Tiying Suo et al.   JOURNAL OF HAZARDOUS MATERIALS

Protein Spherical Nucleic Acids for Live-Cell Chemical Analysis

(2020) Devleena Samanta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

(2020) Elaine Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Versatile Turn-on Fluorometric Biosensing Profile Based on Split Aptamers-Involved Assembly of NanoCluster Beacon Sandwich

(2020) Tiying Suo et al.   SENSORS AND ACTUATORS B-CHEMICAL

Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells

(2019) Long Ma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

RNA Strand Displacement Responsive CRISPR/Cas9 System for mRNA Sensing

(2019) Yue Li et al.   ANALYTICAL CHEMISTRY

circ MAN 1A2 could serve as a novel serum biomarker for malignant tumors

(2019) Chun‐Mei Fan et al.   CANCER SCIENCE

Sensitive detection of DNA from Chlamydia trachomatis by using flap endonuclease-assisted amplification and graphene oxide-based fluorescence signaling

(2019) Chang Yeol Lee et al.   MICROCHIMICA ACTA

Biomarker-guided therapy for colorectal cancer: strength in complexity

(2019) Anita Sveen et al.   Nature Reviews Clinical Oncology

Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise

(2019) Daphné Morel et al.   Nature Reviews Clinical Oncology

A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

(2019) Mindong Liang et al.   Nature Communications

FEN1 inhibitor increases sensitivity of radiotherapy in cervical cancer cells

(2019) Jin‐Li Li et al.   Cancer Medicine

Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic-Acid Targets

(2019) Ying Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rolling circle amplification for single cell analysis and in situ sequencing

(2019) Hua Gao et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non–Small-Cell Lung Cancer

(2018) Keqiang Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Exponential isothermal amplification of nucleic acids and amplified assays for proteins, cells, and enzyme activities

(2018) Michael S Reid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells

(2018) Lingfeng He et al.   DNA REPAIR

Recombinase polymerase amplification: Basics, applications and recent advances

(2018) Ivan Magriñá Lobato et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems

(2018) Hao Zhang et al.   NANO LETTERS

Detecting transcription factors with allosteric DNA-Silver nanocluster switches

(2018) Bingzhi Li et al.   ANALYTICA CHIMICA ACTA

A simple dendrimer-aptamer based microfluidic platform for E. coli O157:H7 detection and signal intensification by rolling circle amplification

(2017) Yuqian Jiang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Investigation of human flap structure-specific endonuclease 1 (FEN1) activity on primer-template models and exploration of a substrate-based FEN1 inhibitor

(2016) Sai Ba et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

(2016) Hong-Min Meng et al.   CHEMICAL SOCIETY REVIEWS

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Functional FEN1 genetic variants and haplotypes are associated with glioma risk

(2012) Yi-Dong Chen et al.   JOURNAL OF NEURO-ONCOLOGY

Aptamer in Bioanalytical Applications

(2011) Anton B. Iliuk et al.   ANALYTICAL CHEMISTRY

FEN Nucleases: Bind, Bend, Fray, Cut

(2011) R. Scott Williams et al.   CELL

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Functional Nucleic Acid Sensors

(2009) Juewen Liu et al.   CHEMICAL REVIEWS

DNAzymes for sensing, nanobiotechnology and logic gate applications

(2008) Itamar Willner et al.   CHEMICAL SOCIETY REVIEWS