CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-08-07
DOI
10.3389/fonc.2020.01387
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Generalizable sgRNA design for improved CRISPR/Cas9 editing efficiency
- (2020) Kasidet Hiranniramol et al. BIOINFORMATICS
- Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
- (2020) Majda Bratovič et al. Nature Chemical Biology
- Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR
- (2020) Yicheng Fang et al. RADIOLOGY
- Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′G-extended sgRNAs
- (2020) Péter István Kulcsár et al. Nature Communications
- Enhanced CRISPR-Cas9 correction of Duchenne muscular dystrophy in mice by a self-complementary AAV delivery system
- (2020) Yu Zhang et al. Science Advances
- High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells
- (2020) Hui Kwon Kim et al. Nature Biomedical Engineering
- Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza
- (2020) Timothy R. Abbott et al. CELL
- SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective
- (2020) Manuela Sironi et al. INFECTION GENETICS AND EVOLUTION
- The epidemiology, diagnosis and treatment of COVID-19
- (2020) Pan Zhai et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- CRISPR–Cas12-based detection of SARS-CoV-2
- (2020) James P. Broughton et al. NATURE BIOTECHNOLOGY
- Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
- (2020) Russell T. Walton et al. SCIENCE
- Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates
- (2020) Xinyu Ling et al. Science Advances
- Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
- (2019) Morgan L. Maeder et al. NATURE MEDICINE
- CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
- (2019) Grégoire Cullot et al. Nature Communications
- Identification of preexisting adaptive immunity to Cas9 proteins in humans
- (2019) Carsten T. Charlesworth et al. NATURE MEDICINE
- Combined Computational-Experimental Approach to Explore Molecular Mechanism of SaCas9 with Broadened DNA Targeting Range
- (2019) Binquan Luan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Delivery Aspects of CRISPR/Cas for in Vivo Genome Editing
- (2019) Danny Wilbie et al. ACCOUNTS OF CHEMICAL RESEARCH
- Gene Therapy Leaves a Vicious Cycle
- (2019) Reena Goswami et al. Frontiers in Oncology
- Evaluating the Efficiency of gRNAs in CRISPR/Cas9 Mediated Genome Editing in Poplars
- (2019) Tobias Bruegmann et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Delivery of CRISPR/Cas9 for therapeutic genome editing
- (2019) Xiaojie Xu et al. JOURNAL OF GENE MEDICINE
- Did CRISPR help—or harm—the first-ever gene-edited babies?
- (2019) Jon Cohen SCIENCE
- Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy
- (2019) Ana M. Moreno et al. Nature Biomedical Engineering
- Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity
- (2019) Yuanyan Tan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’*
- (2019) Henry T Greely Journal of Law and the Biosciences
- Search-and-replace genome editing without double-strand breaks or donor DNA
- (2019) Andrew V. Anzalone et al. NATURE
- Engineered materials for in vivo delivery of genome-editing machinery
- (2019) Sheng Tong et al. Nature Reviews Materials
- CRISPR base editors: genome editing without double-stranded breaks
- (2018) Ayman Eid et al. BIOCHEMICAL JOURNAL
- Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
- (2018) Silvana Konermann et al. CELL
- First-in-human Phase 1 CRISPR Gene Editing Cancer Trials: Are We Ready?
- (2018) Francoise Baylis et al. CURRENT GENE THERAPY
- Delivering CRISPR: a review of the challenges and approaches
- (2018) Christopher A. Lino et al. DRUG DELIVERY
- Suppressing Ku70/Ku80 expression elevates homology-directed repair efficiency in primary fibroblasts
- (2018) Guoling Li et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology
- (2018) Xiaoshu Xu et al. JOURNAL OF MOLECULAR BIOLOGY
- Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
- (2018) Michael Kosicki et al. NATURE BIOTECHNOLOGY
- A highly specific SpCas9 variant is identified by in vivo screening in yeast
- (2018) Antonio Casini et al. NATURE BIOTECHNOLOGY
- p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
- (2018) Robert J. Ihry et al. NATURE MEDICINE
- CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
- (2018) Emma Haapaniemi et al. NATURE MEDICINE
- Genomics: CRISPR–Cas goes RNA
- (2018) Stéphane Larochelle NATURE METHODS
- RNA-dependent RNA targeting by CRISPR-Cas9
- (2018) Steven C Strutt et al. eLife
- Review of CRISPR/Cas9 sgRNA Design Tools
- (2018) Yingbo Cui et al. Interdisciplinary Sciences-Computational Life Sciences
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
- (2018) Johnny H. Hu et al. NATURE
- A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
- (2018) Christopher A. Vakulskas et al. NATURE MEDICINE
- Engineered CRISPR-Cas9 nuclease with expanded targeting space
- (2018) Hiroshi Nishimasu et al. SCIENCE
- Directed evolution of CRISPR-Cas9 to increase its specificity
- (2018) Jungjoon K. Lee et al. Nature Communications
- Base editing: precision chemistry on the genome and transcriptome of living cells
- (2018) Holly A. Rees et al. NATURE REVIEWS GENETICS
- Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair
- (2018) Anastasia Lomova et al. STEM CELLS
- Minimal PAM specificity of a highly similar SpCas9 ortholog
- (2018) Pranam Chatterjee et al. Science Advances
- Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System
- (2018) Colette Moses et al. Molecular Therapy-Nucleic Acids
- Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
- (2017) Janice S. Chen et al. NATURE
- Correction of a pathogenic gene mutation in human embryos
- (2017) Hong Ma et al. NATURE
- Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain
- (2017) Jun Nishiyama et al. NEURON
- Regulation of the fetal hemoglobin silencing factor BCL11A
- (2016) Anindita Basak et al. Annals of the New York Academy of Sciences
- Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles
- (2016) Kyung-Rok Yu et al. HUMAN GENE THERAPY
- Origins of Programmable Nucleases for Genome Engineering
- (2016) Srinivasan Chandrasegaran et al. JOURNAL OF MOLECULAR BIOLOGY
- Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9
- (2016) Carolin Anders et al. MOLECULAR CELL
- Current Progress in Therapeutic Gene Editing for Monogenic Diseases
- (2016) Versha Prakash et al. MOLECULAR THERAPY
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
- (2016) Christopher D Richardson et al. NATURE BIOTECHNOLOGY
- Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia
- (2016) Francis P. Pankowicz et al. Nature Communications
- Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair
- (2016) Tony Gutschner et al. Cell Reports
- Sequence features associated with the cleavage efficiency of CRISPR/Cas9 system
- (2016) Xiaoxi Liu et al. Scientific Reports
- Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing
- (2015) Nicolas Wyvekens et al. HUMAN GENE THERAPY
- BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations
- (2015) Anindita Basak et al. JOURNAL OF CLINICAL INVESTIGATION
- Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
- (2015) Takeshi Maruyama et al. NATURE BIOTECHNOLOGY
- Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
- (2015) Benjamin P Kleinstiver et al. NATURE BIOTECHNOLOGY
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing
- (2015) Francis Robert et al. Genome Medicine
- Off-target Effects in CRISPR/Cas9-mediated Genome Engineering
- (2015) Xiao-Hui Zhang et al. Molecular Therapy-Nucleic Acids
- Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
- (2014) S. Kim et al. GENOME RESEARCH
- Programmable RNA recognition and cleavage by CRISPR/Cas9
- (2014) Mitchell R. O’Connell et al. NATURE
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
- (2014) Bin Shen et al. NATURE METHODS
- E-CRISP: fast CRISPR target site identification
- (2014) Florian Heigwer et al. NATURE METHODS
- Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
- (2014) Lin Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Disruption of HPV16-E7 by CRISPR/Cas System Induces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical Cancer Cells
- (2014) Zheng Hu et al. Biomed Research International
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Targeted gene therapies: tools, applications, optimization
- (2012) Olivier Humbert et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Fetal hemoglobin in sickle cell anemia
- (2011) I. Akinsheye et al. BLOOD
- CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
- (2011) Elitza Deltcheva et al. NATURE
- Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence
- (2011) E. Semenova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gammaretroviral Vectors: Biology, Technology and Application
- (2011) Tobias Maetzig et al. Viruses-Basel
- Regulation of Homologous Recombination in Eukaryotes
- (2010) Wolf-Dietrich Heyer et al. Annual Review of Genetics
- Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways
- (2010) Yulia Komarova et al. Annual Review of Physiology
- Gene Therapy for SCID-X1: Round 2
- (2010) Roland W Herzog MOLECULAR THERAPY
- Progress and prospects: immune responses to viral vectors
- (2009) S Nayak et al. GENE THERAPY
- The biology of CCR5 and CXCR4
- (2009) Ghalib Alkhatib Current Opinion in HIV and AIDS
- Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes
- (2008) S. J. J. Brouns et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search