Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

Neuroimmune cardiovascular interfaces control atherosclerosis

(2022) Sarajo K. Mohanta et al.   NATURE

MicroRNA Biophysically Modulates Cardiac Action Potential via Directly Binding to Ion Channel

(2021) Dandan Yang et al.   CIRCULATION

The cardiac translational landscape reveals that micropeptides are new players involved in cardiomyocyte hypertrophy

(2021) Youchen Yan et al.   MOLECULAR THERAPY

METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells

(2021) Aránzazu Chamorro-Jorganes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types

(2021) Pierre R. Moreau et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

(2021) Susmita Sahoo et al.   CIRCULATION

Evidence That Regulation of Pri-miRNA/miRNA Expression Is Not a General Rule of miPEPs Function in Humans

(2021) Anne Prel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions

(2021) Andreas Schober et al.   CIRCULATION

NORAD-induced Pumilio phase separation is required for genome stability

(2021) Mahmoud M. Elguindy et al.   NATURE

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

(2021) Gaspare La Rocca et al.   eLife

Subcellular Localization of miRNAs and Implications in Cellular Homeostasis

(2021) Minwen Jie et al.   Genes

miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis

(2021) Fang Li et al.   Aging-US

PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Triggers Vascular Smooth Muscle Cell Senescence and Apoptosis: Implication of Its Direct Role in Degenerative Vascular Disease

(2021) Yanan Guo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

microRNA-17-5p downregulation inhibits autophagy and myocardial remodelling after myocardial infarction by targeting STAT3

(2021) Bo Chen et al.   AUTOIMMUNITY

MicroRNA sequence codes for small extracellular vesicle release and cellular retention

(2021) Ruben Garcia-Martin et al.   NATURE

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

HuR (Human Antigen R) Regulates the Contraction of Vascular Smooth Muscle and Maintains Blood Pressure

(2020) Shanshan Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

miR-128-3p Is a Novel Regulator of Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Diseases

(2020) Floriana M Farina et al.   CIRCULATION RESEARCH

A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation

(2020) Liman Niu et al.   Science Advances

MiR-17 Knockdown Promotes Vascular Smooth Muscle Cell Phenotypic Modulation Through Upregulated Interferon Regulator Factor 9 Expression

(2020) Wenyan Li et al.   AMERICAN JOURNAL OF HYPERTENSION

Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy

(2020) Huijie Guo et al.   CELL DEATH AND DIFFERENTIATION

Extracellular vesicular MicroRNA-27a* contributes to cardiac hypertrophy in chronic heart failure

(2020) Changhai Tian et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Position-specific oxidation of miR-1 encodes cardiac hypertrophy

(2020) Heeyoung Seok et al.   NATURE

Partitioning of cancer therapeutics in nuclear condensates

(2020) Isaac A. Klein et al.   SCIENCE

Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis

(2020) Donato Santovito et al.   Science Translational Medicine

Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study

(2020) Wesley Tyler Abplanalp et al.   Nucleic Acid Therapeutics

Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease

(2020) Linsey J. F. Peters et al.   Frontiers in Physiology

Adenosine-to-Inosine editing of vasoactive microRNAs alters their targetome and function in ischemia Van der Kwast. Post-ischemic microRNA A-to-I editing

(2020) Reginald V.C.T. van der Kwast et al.   Molecular Therapy-Nucleic Acids

Differentially expressed lnc‐NOS2P3‐miR‐939‐5p axis in chronic heart failure inhibits myocardial and endothelial cells apoptosis via iNOS/TNFα pathway

(2020) Cuncun Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA

(2020) Min Kang et al.   Molecular Cancer

Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation

(2020) Despoina Kesidou et al.   Frontiers in Physiology

Hematopoietic Deficiency of the Long Non-Coding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation

(2019) Sebastian Cremer et al.   CIRCULATION

mirtronDB: a mirtron knowledge base

(2019) Bruno Henrique Ribeiro Da Fonseca et al.   BIOINFORMATICS

Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2

(2019) Jessica Sheu‐Gruttadauria et al.   EMBO JOURNAL

MiR-451 antagonist protects against cardiac fibrosis in streptozotocin-induced diabetic mouse heart

(2019) Cui Liang et al.   LIFE SCIENCES

MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis

(2019) Yingxue Su et al.   Cell Death & Disease

The Translational Landscape of the Human Heart

(2019) Sebastiaan van Heesch et al.   CELL

Wnt signalling mediates miR-133a nuclear re-localization for the transcriptional control of Dnmt3b in cardiac cells

(2019) Vittoria Di Mauro et al.   Scientific Reports

HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling

(2019) Han Hu et al.   CARDIOVASCULAR RESEARCH

The Different Roles of miRNA-92a-2-5p and let-7b-5p in Mitochondrial Translation in db/db Mice

(2019) Huaping Li et al.   Molecular Therapy-Nucleic Acids

Systematic review of microRNA biomarkers in acute coronary syndrome and stable coronary artery disease

(2019) Amanpreet Kaur et al.   CARDIOVASCULAR RESEARCH

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

(2019) Marcelo A. Mori et al.   Cell Metabolism

MicroRNA-411 and Its 5′-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia

(2019) Reginald V.C.T. van der Kwast et al.   MOLECULAR THERAPY

Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription

(2019) Jiahui Fan et al.   Science China-Life Sciences

Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart

(2019) Huaping Li et al.   CIRCULATION RESEARCH

Identification of ncRNA-Mediated Functions of Nucleus-Localized miR-320 in Cardiomyocytes

(2019) Huaping Li et al.   Molecular Therapy-Nucleic Acids

Endosomal TLR-8 Senses microRNA-1294 Resulting in the Production of NFḱB Dependent Cytokines

(2019) Linda Pluta et al.   Frontiers in Immunology

Serum extracellular vesicles promote proliferation of H9C2 cardiomyocytes by increasing miR-17-3p

(2018) Zhuyuan Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Knockdown of lncRNA MALAT1 attenuates acute myocardial infarction through miR-320-Pten axis

(2018) Hao Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

Phase Transitions in the Assembly and Function of Human miRISC

(2018) Jessica Sheu-Gruttadauria et al.   CELL

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

miR-21 promotes cardiac fibroblast-to-myofibroblast transformation and myocardial fibrosis by targeting Jagged1

(2018) Xue-liang Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

(2018) Indrabahadur Singh et al.   NATURE GENETICS

A brave new world of RNA-binding proteins

(2018) Matthias W. Hentze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus

(2018) Qingjian Han et al.   NEURON

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Autophagic degradation of SQSTM1 inhibits ovarian cancer motility by decreasing DICER1 and AGO2 to induce MIRLET7A-3P

(2018) Chiao-Chun Liao et al.   Autophagy

MiR-320 regulates cardiomyocyte apoptosis induced by ischemia–reperfusion injury by targeting AKIP1

(2018) Zhi-Qiang Tian et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells

(2018) Aishe A. Sarshad et al.   MOLECULAR CELL

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel class of microRNA-recognition elements that function only within open reading frames

(2018) Kai Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MeCP2 interacts with chromosomal microRNAs in brain

(2017) Abdul Waheed Khan et al.   Epigenetics

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

(2017) Wolfgang Poller et al.   EUROPEAN HEART JOURNAL

Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury

(2017) Sergi Guixé-Muntet et al.   JOURNAL OF HEPATOLOGY

Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms

(2017) Yan Feng et al.   JOURNAL OF IMMUNOLOGY

Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase)

(2017) Danielle L. Shepherd et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells

(2017) Lakshmi Sripada et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level

(2017) Dong Wang et al.   NUCLEIC ACIDS RESEARCH

Human Argonaute3 has slicer activity

(2017) Mi Seul Park et al.   NUCLEIC ACIDS RESEARCH

MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting

(2017) Pin Lu et al.   PLoS One

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

(2017) Anne-Clemence Vion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

(2017) Ozlem Tufanli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mining for Micropeptides

(2017) Catherine A. Makarewich et al.   TRENDS IN CELL BIOLOGY

A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction

(2017) Paishiun N. Hsieh et al.   Nature Communications

Region and cell-type resolved quantitative proteomic map of the human heart

(2017) Sophia Doll et al.   Nature Communications

miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury

(2017) Jing Shi et al.   Theranostics

Resolving Subcellular miRNA Trafficking and Turnover at Single-Molecule Resolution

(2017) Sethuramasundaram Pitchiaya et al.   Cell Reports

Viral Infection Identifies Micropeptides Differentially Regulated in smORF-Containing lncRNAs

(2017) Brandon Razooky et al.   Genes

Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization

(2017) Reginald V.C.T. van der Kwast et al.   CIRCULATION RESEARCH

A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme

(2017) Deepanjan Paul et al.   Scientific Reports

Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair

(2016) Farima Zahedi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial TranslationClinical Perspective

(2016) Huaping Li et al.   CIRCULATION

Reversible HuR‐microRNA binding controls extracellular export of miR‐122 and augments stress response

(2016) Kamalika Mukherjee et al.   EMBO REPORTS

MicroRNAs in Cardiovascular Disease

(2016) Temo Barwari et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

(2016) Konstantinos Stellos et al.   NATURE MEDICINE

Structural basis of mRNA-cap recognition by Dcp1–Dcp2

(2016) Jeffrey S Mugridge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DDX6–4E-T interaction mediates translational repression and P-body assembly

(2016) Anastasiia Kamenska et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-27 Prevents Atherosclerosis by Suppressing Lipoprotein Lipase-Induced Lipid Accumulation and Inflammatory Response in Apolipoprotein E Knockout Mice

(2016) Wei Xie et al.   PLoS One

MicroRNAs activate gene transcription epigenetically as an enhancer trigger

(2016) Min Xiao et al.   RNA Biology

Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4

(2016) Petra Hartmann et al.   Nature Communications

Structural basis of mRNA-cap recognition by Dcp1–Dcp2

(2016) Jeffrey S Mugridge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

MicroRNA Mediation of Endothelial Inflammatory Response to Smooth Muscle Cells and Its Inhibition by Atheroprotective Shear StressNovelty and Significance

(2015) Li-Jing Chen et al.   CIRCULATION RESEARCH

Long Noncoding RNAs and MicroRNAs in Cardiovascular Pathophysiology

(2015) T. Thum et al.   CIRCULATION RESEARCH

VEGF-Induced Expression of miR-17–92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates AngiogenesisNovelty and Significance

(2015) Aránzazu Chamorro-Jorganes et al.   CIRCULATION RESEARCH

Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic HeartCLINICAL PERSPECTIVE

(2015) Rajaganapathi Jagannathan et al.   Circulation-Cardiovascular Genetics

Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis

(2015) Johan M. Lorenzen et al.   EUROPEAN HEART JOURNAL

Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor

(2015) Diane Bortolamiol-Becet et al.   MOLECULAR CELL

Primary transcripts of microRNAs encode regulatory peptides

(2015) Dominique Lauressergues et al.   NATURE

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis

(2015) Andreas Schober et al.   Nature Reviews Cardiology

Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity

(2015) Aristeidis G. Telonis et al.   NUCLEIC ACIDS RESEARCH

RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4

(2015) D K Poria et al.   ONCOGENE

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA

(2015) Gaspare La Rocca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic HeartCLINICAL PERSPECTIVE

(2015) Rajaganapathi Jagannathan et al.   Circulation-Cardiovascular Genetics

miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8

(2014) Mengwen Yan et al.   CARDIOVASCULAR RESEARCH

Argonaute-Bound Small RNAs from Promoter-Proximal RNA Polymerase II

(2014) Jesse R. Zamudio et al.   CELL

MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation

(2014) Xiaorong Zhang et al.   CELL

Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice

(2014) L. Goedeke et al.   EMBO Molecular Medicine

A challenge for miRNA: multiple isomiRs in miRNAomics

(2014) Li Guo et al.   GENE

Plasma Exosome MicroRNA Profiling Unravels a New Potential Modulator of Adiponectin Pathway in Diabetes: Effect of Glycemic Control

(2014) Donato Santovito et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1

(2014) Andreas Schober et al.   NATURE MEDICINE

MicroRNAs in myocardial infarction

(2014) Reinier A. Boon et al.   Nature Reviews Cardiology

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

5′ isomiR variation is of functional and evolutionary importance

(2014) Geok Chin Tan et al.   NUCLEIC ACIDS RESEARCH

Differential RISC association of endogenous human microRNAs predicts their inhibitory potential

(2014) Omar Flores et al.   NUCLEIC ACIDS RESEARCH

miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo

(2014) Samarjit Das et al.   PLoS One

Mature MiRNAs Form Secondary Structure, which Suggests Their Function beyond RISC

(2014) Agnieszka Belter et al.   PLoS One

Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs

(2014) Yijun Zhang et al.   RNA

Structural basis for microRNA targeting

(2014) N. T. Schirle et al.   SCIENCE

RNAi Factors Are Present and Active in Human Cell Nuclei

(2014) Keith T. Gagnon et al.   Cell Reports

RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes

(2013) Elmar Wahle et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance

(2013) Monique Ohanian et al.   BMC GENETICS

Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding

(2013) Aleksandra Helwak et al.   CELL

The mitochondrial genome encodes abundant small noncoding RNAs

(2013) Seungil Ro et al.   CELL RESEARCH

mir-17–92 Cluster Is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts

(2013) Jinghai Chen et al.   CIRCULATION RESEARCH

miR-17 targets tissue inhibitor of metalloproteinase 1 and 2 to modulate cardiac matrix remodeling

(2013) Shu-Hong Li et al.   FASEB JOURNAL

A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels

(2013) Kanae Hasegawa et al.   HEART RHYTHM

A Regulatory Role for MicroRNA 33* in Controlling Lipid Metabolism Gene Expression

(2013) L. Goedeke et al.   MOLECULAR AND CELLULAR BIOLOGY

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

(2013) P. Mathiyalagan et al.   NUCLEIC ACIDS RESEARCH

Structural features of Argonaute-GW182 protein interactions

(2013) J. Pfaff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

(2013) Eleonora Leucci et al.   Scientific Reports

Poly(A)-Specific Ribonuclease Mediates 3′-End Trimming of Argonaute2-Cleaved Precursor MicroRNAs

(2013) Mayuko Yoda et al.   Cell Reports

Ago1 Interacts with RNA Polymerase II and Binds to the Promoters of Actively Transcribed Genes in Human Cancer Cells

(2013) Vera Huang et al.   PLoS Genetics

Mirtron MicroRNA-1236 Inhibits VEGFR-3 Signaling During Inflammatory Lymphangiogenesis

(2012) Dennis Jones et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1

(2012) Xiaohong Wang et al.   CARDIOVASCULAR RESEARCH

Nuclear miRNA Regulates the Mitochondrial Genome in the Heart

(2012) Samarjit Das et al.   CIRCULATION RESEARCH

A novel reciprocal loop between microRNA-21 and TGFβRIII is involved in cardiac fibrosis

(2012) Haihai Liang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells

(2012) Jasenka Guduric-Fuchs et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Consistent isomiR expression patterns and 3′ addition events in miRNA gene clusters and families implicate functional and evolutionary relationships

(2012) Li Guo et al.   MOLECULAR BIOLOGY REPORTS

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

(2012) Pradipta Kundu et al.   NUCLEIC ACIDS RESEARCH

Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses

(2012) S. H. Olejniczak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver

(2012) J. R. Androsavich et al.   RNA

Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

(2012) K. Nishi et al.   RNA

Alternative RISC assembly: Binding and repression of microRNA-mRNA duplexes by human Ago proteins

(2012) M. M. Janas et al.   RNA

Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs

(2012) C. Voellenkle et al.   RNA

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A

(2011) C. Urbich et al.   BLOOD

A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1 currents

(2011) T. Hattori et al.   CARDIOVASCULAR RESEARCH

The Human Mitochondrial Transcriptome

(2011) Tim R. Mercer et al.   CELL

Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system

(2011) Rui Tang et al.   CELL RESEARCH

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

(2011) Wei Wu et al.   CIRCULATION

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2011) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin

(2011) Alexander Maxwell Burroughs et al.   RNA Biology

Deep sequencing of microRNA precursors reveals extensive 3' end modification

(2011) M. A. Newman et al.   RNA

Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells

(2010) C. Doebele et al.   BLOOD

MicroRNA profiling during mouse ventricular maturation: a role for miR-27 modulating Mef2c expression

(2010) Ana Chinchilla et al.   CARDIOVASCULAR RESEARCH

Transcriptional Control of Gene Expression by MicroRNAs

(2010) Basel Khraiwesh et al.   CELL

miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

(2010) Anna M. Eiring et al.   CELL

Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes

(2010) Anna Zampetaki et al.   CIRCULATION RESEARCH

Circulating microRNAs are new and sensitive biomarkers of myocardial infarction

(2010) Yuri D'Alessandra et al.   EUROPEAN HEART JOURNAL

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

(2010) H. R. Chiang et al.   GENES & DEVELOPMENT

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3 

(2010) D. M. Patrick et al.   GENES & DEVELOPMENT

Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death

(2010) Xiaowei Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

(2010) Shintaro Iwasaki et al.   MOLECULAR CELL

Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing

(2010) Chanseok Shin et al.   MOLECULAR CELL

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

(2010) Sihem Cheloufi et al.   NATURE

Export of microRNAs and microRNA-protective protein by mammalian cells

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

Dynamic isomiR regulation in Drosophila development

(2010) S. L. Fernandez-Valverde et al.   RNA

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

(2010) D. Cifuentes et al.   SCIENCE

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

(2009) Sashwati Roy et al.   CARDIOVASCULAR RESEARCH

Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs

(2009) Lasse Weinmann et al.   CELL

MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20

(2009) Xiao-Ping Ren et al.   CIRCULATION

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

(2009) Sung Wook Chi et al.   NATURE

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

Conditional Dicer Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling

(2008) Paula A. da Costa Martins et al.   CIRCULATION

miR-126 Regulates Angiogenic Signaling and Vascular Integrity

(2008) Jason E. Fish et al.   DEVELOPMENTAL CELL

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

A Human snoRNA with MicroRNA-Like Functions

(2008) Christine Ender et al.   MOLECULAR CELL

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells

(2008) Thomas Ohrt et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

(2008) T. A. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA