Subcellular Localization of miRNAs and Implications in Cellular Homeostasis

Hypoxia downregulated miR-4521 suppresses gastric carcinoma progression through regulation of IGF2 and FOXM1

(2021) Shan Xing et al.   Molecular Cancer

Global miRNA dosage control of embryonic germ layer specification

(2021) Yingzi Cui et al.   NATURE

Axonal precursor mi RNA s hitchhike on endosomes and locally regulate the development of neural circuits

(2020) Eloina Corradi et al.   EMBO JOURNAL

MicroRNA and Cardiovascular Diseases

(2020) Hüseyin Altuğ Çakmak et al.   Balkan Medical Journal

ncRNAs: New Players in Mitochondrial Health and Disease?

(2020) Mirjana Gusic et al.   Frontiers in Genetics

Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA

(2020) Alexander C. Partin et al.   MOLECULAR CELL

The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs

(2020) Wang-Xia Wang et al.   MOLECULAR NEUROBIOLOGY

Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy

(2020) Huijie Guo et al.   CELL DEATH AND DIFFERENTIATION

An Endoplasmic Reticulum Stress‐MicroRNA‐26a Feedback Circuit in Nonalcoholic Fatty Liver Disease

(2020) Haixia Xu et al.   HEPATOLOGY

Endoplasmic reticulum stress‐induced exosomal miR‐27a‐3p promotes immune escape in breast cancer via regulating PD‐L1 expression in macrophages

(2020) Xiaoli Yao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Partitioning of cancer therapeutics in nuclear condensates

(2020) Isaac A. Klein et al.   SCIENCE

Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke

(2020) Wenwen Si et al.   Frontiers in Molecular Neuroscience

MicroRNAs: From Mechanism to Organism

(2020) Philipp J. Dexheimer et al.   Frontiers in Cell and Developmental Biology

miR-328-3p overexpression attenuates the malignant proliferation and invasion of liver cancer via targeting Endoplasmic Reticulum Metallo Protease 1 to inhibit AKT phosphorylation

(2020) Hua Lu et al.   Annals of Translational Medicine

Circ_002117 binds to microRNA-370 and promotes endoplasmic reticulum stress-induced apoptosis in gastric cancer

(2020) Nan Zhou et al.   Cancer Cell International

Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA

(2020) Min Kang et al.   Molecular Cancer

MAC5, an RNA-binding protein, protects pri-miRNAs from SERRATE-dependent exoribonuclease activities

(2020) Shengjun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Mediated Feedback Control of Transcriptional Condensates

(2020) Jonathan E. Henninger et al.   CELL

Functional Atlas of Primary miRNA Maturation by the Microprocessor

(2020) Greggory M. Rice et al.   MOLECULAR CELL

Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis

(2020) Dongqi Xie et al.   NATURE CELL BIOLOGY

Mitochondrial miRNA determines chemoresistance by reprogramming metabolism and regulating mitochondrial transcription

(2019) Song Fan et al.   CANCER RESEARCH

miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke

(2019) Wenwen Si et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Endoplasmic Reticulum Stress Promotes Liver Cancer Cells to Release Exosomal miR-23a-3p and Up-regulate PD-L1 Expression in Macrophages

(2019) Jiatao Liu et al.   HEPATOLOGY

Interplay between miRNAs and host genes and their role in cancer

(2019) Baohong Liu et al.   Briefings in Functional Genomics

Mitochondrial DNA: Distribution, Mutations, and Elimination

(2019) Yan et al.   Cells

Stress granule: a promising target for cancer treatment

(2019) Xiaomeng Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

MicroRNAs: Turning the Tide in Testicular Cancer

(2019) Nirmish Singla et al.   EUROPEAN UROLOGY

m6A enhances the phase separation potential of mRNA

(2019) Ryan J. Ries et al.   NATURE

Chromatin-associated RNAs as facilitators of functional genomic interactions

(2019) Xiao Li et al.   NATURE REVIEWS GENETICS

Mitochondrial miR-762 regulates apoptosis and myocardial infarction by impairing ND2

(2019) Kaowen Yan et al.   Cell Death & Disease

Wnt signalling mediates miR-133a nuclear re-localization for the transcriptional control of Dnmt3b in cardiac cells

(2019) Vittoria Di Mauro et al.   Scientific Reports

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

(2019) Tiia A. Turunen et al.   Scientific Reports

RNA Interactions Are Essential for CTCF-Mediated Genome Organization

(2019) Ricardo Saldaña-Meyer et al.   MOLECULAR CELL

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

(2019) Yang Eric Guo et al.   NATURE

ncRNA-Encoded Peptides or Proteins and Cancer

(2019) Jizhong Wang et al.   MOLECULAR THERAPY

Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription

(2019) Jiahui Fan et al.   Science China-Life Sciences

Biomolecular condensates in neurodegeneration and cancer

(2019) Stephanie Spannl et al.   TRAFFIC

The Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation

(2019) Christiaan J. Stavast et al.   Cells

Nuclear miR-320 Controls Lipotoxicity

(2019) Mingming Tong et al.   CIRCULATION RESEARCH

Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart

(2019) Huaping Li et al.   CIRCULATION RESEARCH

Identification of ncRNA-Mediated Functions of Nucleus-Localized miR-320 in Cardiomyocytes

(2019) Huaping Li et al.   Molecular Therapy-Nucleic Acids

A microRNA's Journey to the Center of the Mitochondria

(2018) Anne M Macgregor-Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phase Transitions in the Assembly and Function of Human miRISC

(2018) Jessica Sheu-Gruttadauria et al.   CELL

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

MicroRNAs in endothelial cell homeostasis and vascular disease

(2018) Carlos Fernández-Hernando et al.   CURRENT OPINION IN HEMATOLOGY

miRNA targeting and alternative splicing in the stress response – events hosted by membrane-less compartments

(2018) Mariya M. Kucherenko et al.   JOURNAL OF CELL SCIENCE

miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin

(2018) Sujith Rajan et al.   JOURNAL OF ENDOCRINOLOGY

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

(2018) Indrabahadur Singh et al.   NATURE GENETICS

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Phase separation of a yeast prion protein promotes cellular fitness

(2018) Titus M. Franzmann et al.   SCIENCE

SnapShot: Unconventional miRNA Functions

(2018) Mihnea Paul Dragomir et al.   CELL

Phase Separation in Biology and Disease

(2018) Julie D. Forman-Kay et al.   JOURNAL OF MOLECULAR BIOLOGY

Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells

(2018) Aishe A. Sarshad et al.   MOLECULAR CELL

SWI2/SNF2 ATPase CHR2 remodels pri-miRNAs via Serrate to impede miRNA production

(2018) Zhiye Wang et al.   NATURE

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

miRBase: from microRNA sequences to function

(2018) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC

(2018) Young-Jun Jeon et al.   Nature Communications

Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase)

(2017) Danielle L. Shepherd et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells

(2017) Lakshmi Sripada et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level

(2017) Dong Wang et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1

(2017) Modar Kassan et al.   Scientific Reports

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

(2016) Caterina Catalanotto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNAs activate gene transcription epigenetically as an enhancer trigger

(2016) Min Xiao et al.   RNA Biology

TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

(2016) Mohamed Fareh et al.   Nature Communications

miRNA Deregulation in Cancer Cells and the Tumor Microenvironment

(2016) R. Rupaimoole et al.   Cancer Discovery

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

Circulating cell-free miRNAs as biomarker for triple-negative breast cancer

(2015) V Y Shin et al.   BRITISH JOURNAL OF CANCER

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

(2015) A. Emde et al.   EMBO JOURNAL

Primary transcripts of microRNAs encode regulatory peptides

(2015) Dominique Lauressergues et al.   NATURE

R loops regulate promoter-proximal chromatin architecture and cellular differentiation

(2015) Poshen B Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

R loops regulate promoter-proximal chromatin architecture and cellular differentiation

(2015) Poshen B Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation

(2014) Xiaorong Zhang et al.   CELL

Identification of nuclear-enriched miRNAs during mouse granulopoiesis

(2014) Justin JL Wong et al.   Journal of Hematology & Oncology

Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs

(2014) Yijun Zhang et al.   RNA

The mitochondrial genome encodes abundant small noncoding RNAs

(2013) Seungil Ro et al.   CELL RESEARCH

MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor δ in human monocytes during the inflammatory response

(2013) PETRA THULIN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis

(2013) Jia-Xing Zhang et al.   LANCET ONCOLOGY

Functionally Diverse MicroRNA Effector Complexes Are Regulated by Extracellular Signaling

(2013) Pei-Hsuan Wu et al.   MOLECULAR CELL

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

(2013) Eleonora Leucci et al.   Scientific Reports

Transcriptional and epigenetic regulation of human microRNAs

(2012) Zifeng Wang et al.   CANCER LETTERS

Nuclear miRNA Regulates the Mitochondrial Genome in the Heart

(2012) Samarjit Das et al.   CIRCULATION RESEARCH

Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma

(2012) OSAMU DOHI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation

(2012) C. L. Lin et al.   NUCLEIC ACIDS RESEARCH

Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

(2012) K. Nishi et al.   RNA

The Human Mitochondrial Transcriptome

(2011) Tim R. Mercer et al.   CELL

Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system

(2011) Rui Tang et al.   CELL RESEARCH

Upregulation of Cyclin B1 by miRNA and its implications in cancer

(2011) Vera Huang et al.   NUCLEIC ACIDS RESEARCH

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

(2010) Dieter Edbauer et al.   NEURON

Silencing by small RNAs is linked to endosomal trafficking

(2009) Young Sik Lee et al.   NATURE CELL BIOLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

(2008) Yan Zeng et al.   BIOCHEMICAL JOURNAL

Antisense transcripts are targets for activating small RNAs

(2008) Jacob C Schwartz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY