Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

Atherosclerotic Conditions Promote the Packaging of Functional MicroRNA-92a-3p into Endothelial Microvesicles

(2019) Yangyang Liu et al.   CIRCULATION RESEARCH

Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells

(2019) Min Cheng et al.   Nature Communications

Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection

(2019) Zuoxu Hou et al.   CIRCULATION RESEARCH

exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids

(2019) Oscar D. Murillo et al.   CELL

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

(2019) Li Qiao et al.   JOURNAL OF CLINICAL INVESTIGATION

exceRpt: A Comprehensive Analytic Platform for Extracellular RNA Profiling

(2019) Joel Rozowsky et al.   Cell Systems

Insight into the Role of Extracellular Vesicles in Lysosomal Storage Disorders

(2019) Brunella Tancini et al.   Genes

Long noncoding RNA-enriched vesicles secreted by hypoxic cardiomyocytes drive cardiac fibrosis

(2019) Franziska Kenneweg et al.   Molecular Therapy-Nucleic Acids

Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories

(2019) Ahmed G. E. Ibrahim et al.   Nature Biomedical Engineering

FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair

(2018) Prabhu Mathiyalagan et al.   CIRCULATION

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial InfarctionNovelty and Significance

(2018) Xavier Loyer et al.   CIRCULATION RESEARCH

Extracellular vesicles and their content in bioactive lipid mediators: more than a sack of microRNA

(2018) Eric Boilard   JOURNAL OF LIPID RESEARCH

Exosomes in Myocardial Repair: Advances and Challenges in the Development of Next-Generation Therapeutics

(2018) Marta Adamiak et al.   MOLECULAR THERAPY

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients

(2018) Damiana Pieragostino et al.   Scientific Reports

Coronary Serum Exosomes Derived from Patients with Myocardial Ischemia Regulate Angiogenesis through the miR-939-mediated Nitric Oxide Signaling Pathway

(2018) Hao Li et al.   Theranostics

miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN

(2018) Xiang Nie et al.   Molecular Therapy-Nucleic Acids

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Exosomal Mst1 transfer from cardiac microvascular endothelial cells to cardiomyocytes deteriorates diabetic cardiomyopathy

(2018) Jianqiang Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Soluble Factors from Human Mesenchymal Stem Cells

(2018) Shohei Yoshida et al.   MOLECULAR THERAPY

Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics

(2018) Kenneth P. Hough et al.   Scientific Reports

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning

(2018) Sean M. Davidson et al.   Scientific Reports

Engineered Exosomes With Ischemic Myocardium‐Targeting Peptide for Targeted Therapy in Myocardial Infarction

(2018) Xu Wang et al.   Journal of the American Heart Association

MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction

(2018) Teng Ma et al.   Stem Cells International

Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

(2018) Gabriella Andriolo et al.   Frontiers in Physiology

Circulating blood cells and extracellular vesicles in acute cardioprotection

(2018) Sean M Davidson et al.   CARDIOVASCULAR RESEARCH

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes for Angiogenesis

(2018) Chengwei Ju et al.   Journal of Cardiovascular Translational Research

Extracellular Vesicles Released by Human Induced-Pluripotent Stem Cell-Derived Cardiomyocytes Promote Angiogenesis

(2018) Julie A. Dougherty et al.   Frontiers in Physiology

Manufacturing of Human Extracellular Vesicle-Based Therapeutics for Clinical Use

(2017) Mario Gimona et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Imaging flow cytometry for the characterization of extracellular vesicles

(2017) Joanne Lannigan et al.   METHODS

Pericardial Fluid Exosomes: A New Material to Treat Cardiovascular Disease

(2017) Susmita Sahoo et al.   MOLECULAR THERAPY

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis

(2017) Cristina Beltrami et al.   MOLECULAR THERAPY

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

(2017) Chunxiao Wang et al.   MOLECULAR THERAPY

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

(2017) Jan Van Deun et al.   NATURE METHODS

Viral effects on the content and function of extracellular vesicles

(2017) Nancy Raab-Traub et al.   NATURE REVIEWS MICROBIOLOGY

Extracellular vesicles from activated platelets: a semiquantitative cryo-electron microscopy and immuno-gold labeling study

(2017) Alain R. Brisson et al.   PLATELETS

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

(2017) Matthew J. Shurtleff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Exosome and Microvesicle-Enriched Fractions Isolated from Mesenchymal Stem Cells by Gradient Separation Showed Different Molecular Signatures and Functions on Renal Tubular Epithelial Cells

(2017) Federica Collino et al.   Stem Cell Reviews and Reports

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

(2017) Zhiyun Wei et al.   Nature Communications

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting

(2017) Georgia K. Atkin-Smith et al.   Scientific Reports

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

(2017) Agnes T. Reiner et al.   Stem Cells Translational Medicine

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

(2017) Jinyun Zhu et al.   Artificial Cells Nanomedicine and Biotechnology

Exosome and Microvesicle-Enriched Fractions Isolated from Mesenchymal Stem Cells by Gradient Separation Showed Different Molecular Signatures and Functions on Renal Tubular Epithelial Cells

(2017) Federica Collino et al.   Stem Cell Reviews and Reports

Potential Role of Exosomes in Mending a Broken Heart: Nanoshuttles Propelling Future Clinical Therapeutics Forward

(2017) Julie A. Dougherty et al.   Stem Cells International

Induced Pluripotent Stem Cell (iPSC)–Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs

(2017) Marta Adamiak et al.   CIRCULATION RESEARCH

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Experimental, Systems, and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell–Derived Exosomes From Pediatric PatientsNovelty and Significance

(2016) Udit Agarwal et al.   CIRCULATION RESEARCH

Erratum: Exosome-associated AAV vector as a robust and convenient neuroscience tool

(2016) E Hudry et al.   GENE THERAPY

Exosome-associated AAV vector as a robust and convenient neuroscience tool

(2016) E Hudry et al.   GENE THERAPY

Extracellular vesicle isolation and characterization: toward clinical application

(2016) Rong Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes derived from dendritic cells improve cardiac function via activation of CD4+ T lymphocytes after myocardial infarction

(2016) Haibo Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR

(2016) Xavier Gallart-Palau et al.   Molecular Neurodegeneration

Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm

(2016) Benjamin H. Wunsch et al.   Nature Nanotechnology

Development of a magnetic bead-based method for the collection of circulating extracellular vesicles

(2016) Chun-Liang Shih et al.   New Biotechnology

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing

(2016) Cecilia Lässer et al.   RNA Biology

Generation of a novel transgenic rat model for tracing extracellular vesicles in body fluids

(2016) Aya Yoshimura et al.   Scientific Reports

Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway

(2016) Jieyuan Zhang et al.   Stem Cell Research & Therapy

Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21

(2016) Kan Wang et al.   Stem Cells Translational Medicine

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Acoustic Purification of Extracellular Microvesicles

(2015) Kyungheon Lee et al.   ACS Nano

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

(2015) G. Pironti et al.   CIRCULATION

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics

(2015) Sybren L.N. Maas et al.   JOURNAL OF CONTROLLED RELEASE

A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes

(2015) Linmao Lyu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exosomes Explosion for Cardiac Resuscitation∗

(2015) Yaxuan Liang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fibroblasts Rendered Antifibrotic, Antiapoptotic, and Angiogenic by Priming With Cardiosphere-Derived Extracellular Membrane Vesicles

(2015) Eleni Tseliou et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

(2015) Jose M. Vicencio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles

(2015) E. van der Pol et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Driving the Hypoxia-Inducible Pathway in Human Pericytes Promotes Vascular Density in an Exosome-Dependent Manner

(2015) Jamie N. Mayo et al.   MICROCIRCULATION

Improved Characterization of EV Preparations Based on Protein to Lipid Ratio and Lipid Properties

(2015) Xabier Osteikoetxea et al.   PLoS One

The composition and daily variation of microparticles in whole blood in stable coronary artery disease

(2015) Christina Christersson et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

EVpedia: A community web resource for prokaryotic and eukaryotic extracellular vesicles research

(2015) Dae-Kyum Kim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes

(2015) Shivakumar Keerthikumar et al.   Oncotarget

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

(2015) Ana Rosa Soares et al.   Scientific Reports

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Isolation of High-Purity Extracellular Vesicles by Extracting Proteins Using Aqueous Two-Phase System

(2015) Jongmin Kim et al.   PLoS One

Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

(2015) Seiji Yamamoto et al.   Scientific Reports

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo

(2014) Bence György et al.   BIOMATERIALS

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

(2014) L. H. Boudreau et al.   BLOOD

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

The Ether Lipid Precursor Hexadecylglycerol Stimulates the Release and Changes the Composition of Exosomes Derived from PC-3 Cells

(2014) Santosh Phuyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benchtop isolation and characterization of functional exosomes by sequential filtration

(2014) Mitja L. Heinemann et al.   JOURNAL OF CHROMATOGRAPHY A

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing

(2014) E. van der Pol et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes

(2014) Shailender Singh Kanwar et al.   LAB ON A CHIP

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

(2014) Danijela Koppers-Lalic et al.   Cell Reports

Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells

(2014) Mario Leonardo Squadrito et al.   Cell Reports

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

Exosomes from breast milk inhibit HIV-1 infection of dendritic cells and subsequent viral transfer to CD4+ T cells

(2013) Tanja I. Näslund et al.   AIDS

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

(2013) Alicia Llorente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

(2013) B. W. M. van Balkom et al.   BLOOD

Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction

(2013) Sen Matsumoto et al.   CIRCULATION RESEARCH

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

(2013) Julie Halkein et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct lipid compositions of two types of human prostasomes

(2013) Jos F. Brouwers et al.   PROTEOMICS

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Tumor-exosomes and leukocyte activation: an ambivalent crosstalk

(2012) Daniela Zech et al.   Cell Communication and Signaling

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death

(2012) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: Initiated by hypoxia inducible factor 1α, presented by exosomes

(2012) Xian Yu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

(2012) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

(2012) Casey A Maguire et al.   MOLECULAR THERAPY

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry

(2012) Els J van der Vlist et al.   Nature Protocols

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Human Pericytes for Ischemic Heart Repair

(2012) Chien-Wen Chen et al.   STEM CELLS

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Exosomes From Human CD34 + Stem Cells Mediate Their Proangiogenic Paracrine Activity

(2011) Susmita Sahoo et al.   CIRCULATION RESEARCH

Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage

(2011) Yasuhide Kuwabara et al.   Circulation-Cardiovascular Genetics

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells

(2011) Nicole C Dubois et al.   NATURE BIOTECHNOLOGY

A high-throughput label-free nanoparticle analyser

(2011) Jean-Luc Fraikin et al.   Nature Nanotechnology

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

(2010) Nobuyoshi Kosaka et al.   CANCER SCIENCE

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Exosomes/microvesicles as a mechanism of cell-to-cell communication

(2010) Giovanni Camussi et al.   KIDNEY INTERNATIONAL

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

ExoCarta: A compendium of exosomal proteins and RNA

(2009) Suresh Mathivanan et al.   PROTEOMICS

Flow cytometric measurement of microparticles: Pitfalls and protocol modifications

(2008) Mona D. Shah et al.   PLATELETS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE