Article
Chemistry, Medicinal
Zhongwei Zhang, Caiping Song, Tao Wang, Lei Sun, Ling Qin, Jianghua Ju
Summary: The study found that miR-139-5p promotes retinal neovascularization by suppressing PTEN expression. High glucose treatment increases miR-139-5p levels, leading to enhanced cell migration, tube formation, and VEGF protein levels.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Colin Carlock, Yunpeng Bai, Allison Paige-Hood, Qinglin Li, Frederick Nguele Meke, Zhong-Yin Zhang
Summary: Overexpression of PRL2 and reduced PTEN protein are frequently observed in patients with acute myeloid leukemia (AML). Inhibiting PRL2 can prolong animal survival and slow the accumulation of leukemia blasts in the bone marrow niche. This study provides evidence for the viability of PRL2 inhibition as a therapeutic strategy for improving clinical outcomes in AML and other PTEN-deficient cancers.
Article
Biotechnology & Applied Microbiology
Zhenze Lu, Ling Li, Lei Wei, Jifu Cai, Jun Wu
Summary: This study revealed that LOC366613 plays a crucial role in cerebral I/R injury by regulating the miR-532-5p/PTEN axis, mediating biological functions such as cell apoptosis, cell survival, and LDH release.
Article
Medicine, Research & Experimental
Yonghua Lei, Ming Yang, Hong Li, Rongjuan Xu, Junbao Liu
Summary: The study revealed that miR-130b is downregulated in diabetic encephalopathy, and exerts a protective effect against oxidative stress injury by activating the PI3K/Akt signaling pathway through regulating PTEN.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Shang-Yeh Lu, Wei-Zhi Hong, Bruce Chi-Kang Tsai, Yu-Chun Chang, Chia-Hua Kuo, Thomas G. Mhone, Ray-Jade Chen, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study investigated the effects of Ang II on cardiac injury and found that it can lead to cardiac apoptosis by attenuating the IGF1R-PI3K-AKT pathway and activating miR-320-3p transcription. Furthermore, a reduction in IGF1R survival pathway activation was observed in the heart tissue of spontaneously hypertensive rats.
JOURNAL OF HYPERTENSION
(2022)
Article
Medical Laboratory Technology
Lina Wu, Xinpeng Zhang, Lin Luo, Xiaoying Li, Yong Liu, Xiaosong Qin
Summary: The study found that miR-106a, miR-19b, miR-17, and PTEN are involved in the pathogenesis of IMN and may serve as new biomarkers for the diagnosis of IMN.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biotechnology & Applied Microbiology
Nianxue Wang, Bin Yang, Jiao Jin, Yu He, Xijun Wu, Yichen Yang, Weijun Zhou, Zhixu He
Summary: This study identified circ_0040823/miR-516b/PTEN as a new therapeutic target for AML, as circ_0040823 inhibited proliferation and induced apoptosis of AML cells by sponging miR-516b, thereby diminishing the regulatory effect of miR-516b on PTEN.
JOURNAL OF GENE MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Miao-Miao Lu, Yue Ren, Yu-Wei Zhou, Ling-Ling Xu, Meng-Meng Zhang, Lin-Ping Ding, Wei-Xin Cheng, Xi Jin
Summary: Obesity is closely related to the occurrence and development of non-alcoholic steatohepatitis (NASH). The study found that miR-103 derived from adipose tissue may aggravate NASH by interacting with PTEN and inhibiting autophagy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Clinical Neurology
Jiaxu Wang, Meng Li, Jing Zhang, Qing Gao, Zhaoxi Ding, Jinhao Sun
Summary: The aim of this animal study was to investigate the mechanisms underlying the efficacy of paliperidone, an antipsychotic drug approved by the US FDA for the treatment of schizophrenia. The results showed that paliperidone alleviated neuronal damage induced by MK-801 through the PP2A/PTEN pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, Research & Experimental
Gefei Wu, Jiasheng Hu, Hongmin Zhu, Shuhua Wu, Sheng Huang, Zhisheng Liu
Summary: The study demonstrated the therapeutic effect of melatonin (MT) on febrile convulsion (FC) by modulating the MEG3/miR-223/PTEN/AKT pathway, suggesting MT as a novel strategy for FC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Engineering, Mechanical
Nan Liu, Hongli Yang, Shasha Li, Danni Wang, Liangui Yang
Summary: The team constructed a coupling model involving p53-Mdm2 negative feedback loop and p53-PTEN-Mdm2 positive feedback loop, finding that PTEN is crucial for p53 oscillation or bistable switching dynamic behaviors, and the positive feedback loop may enrich the dynamic behaviors of the p53 system.
ACTA MECHANICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Yueli Zhang, Xinchun Wang, Shuyun Wang, Jia Liu, Ruijia Li, Xiaoxia Li, Rui Zhang
Summary: In this study, researchers found that upregulation of circ-ERBB2 promoted the malignancy of colorectal cancer (CRC) cells and reduced their resistance to 5-FU. They identified miR-181a-5p as the target of circ-ERBB2 and verified phosphatase and tensin homolog (PTEN) as miR-181a-5p's downstream target. Circ-ERBB2 activated the Akt pathway and inhibited cell apoptosis by modulating miR-181a-5p/PTEN. The findings suggest that circ-ERBB2 could serve as a valuable biomarker for the diagnosis and treatment of CRC.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Jiayi Huang, Chunshuai Wu, Guanhua Xu, Yue Sun, Chao Gui, Jiawei Fu, Zhiming Cui, Haiming Huang
Summary: The study revealed that the decreased expression of miR-429 in SCI rat plasma exosomes promotes neuronal apoptosis, possibly through the interaction of miR-429 with the downstream target gene PTEN, thereby affecting the PI3K/Akt pathway.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Ziyan Zhao, Jiajie Zhang
Summary: The study found that a lower baseline expression of miR-26a in PBMCs was associated with a higher risk of early-onset neonatal sepsis. Additionally, there was a linear relationship between miR-26a levels and inflammatory markers in septic newborns at baseline. Moreover, the study showed a reverse linear relationship between the expressions of miR-26a and PTEN at baseline.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian'an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang
Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.
Article
Cardiac & Cardiovascular Systems
Jiahui Fan, Huaping Li, Rong Xie, Xudong Zhang, Xiang Nie, Xiaolu Shi, Jiabing Zhan, Zhongwei Yin, Yanru Zhao, Beibei Dai, Shuai Yuan, Zheng Wen, Chen Chen, Dao Wen Wang
Summary: This study aimed to elucidate the role of lncRNA in dilated cardiomyopathy (DCM) and heart failure, with a focus on the ZNF593-AS molecule. Through a series of experiments and observations, the research demonstrated the critical function of ZNF593-AS in improving cardiac function in DCM, potentially offering a new avenue for therapeutic interventions in the future.
CIRCULATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Liyuan Peng, Bei Sun, Yajin Liu, Jing Huang, Guangzhi Chen, Xu Zhang, Chen Chen, Daowen Wang, Gang Wang
Summary: This study found that the increased level of lipoxygenase (LOX) metabolites and decreased levels of eicosanoids derived from cytochrome P450s (CYP450) were significantly correlated with the incidence of diabetic nephropathy (DN) in type 2 diabetes (T2D) patients. LOX and CYP450 metabolites could be potential treatment targets for DN in T2D patients.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Cell Biology
Shuai Yuan, Huaping Li, Chen Chen, Feng Wang, Dao Wen Wang
Summary: The study found that HbAlc levels in COVID-19 patients were significantly associated with overall mortality, as well as correlated with certain biochemical markers. Newly diagnosed diabetes patients with COVID-19 had higher mortality rates, while those with a history of diabetes showed decreased mortality when treated with anti-hyperglycemic drugs.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Physiology
Jinsheng Lai, Chen Chen
Summary: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid produced by cytochrome P450 (CYP) epoxygenases, with beneficial effects against inflammation, fibrosis, and apoptosis in cardiovascular diseases. Studies have shown that increasing EET levels can protect against cardiovascular diseases such as hypertension, myocardial infarction, and heart failure. Therefore, upregulation of EETs may be a potential therapeutic strategy for cardiovascular diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang
Summary: The COVID-19 pandemic has resulted in a large number of deaths globally, with endothelial dysfunction playing a key role in the pathogenesis and anti-inflammation therapy showing effectiveness. There is a call for more attention to be paid to endothelial dysfunction in order to reveal the pathogenic mechanism of COVID-19 and adjust clinical intervention strategies appropriately.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chene Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang
Summary: The study showed that the combination of Shuanghuanglian (SHL) and standard care was safe and partially effective for treating COVID-19, with higher negative conversion rates of SARS-CoV-2 and promoted absorption of pneumonia inflammatory focus. No serious adverse events were reported in the SHL groups.
FRONTIERS OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Hengzhi Du, Yanru Zhao, Huaping Li, Dao Wen Wang, Chen Chen
Summary: miRNAs play a crucial role in heart development and pathological processes, regulating cardiovascular processes and nutrient metabolism. Maintaining cardiac glucose and lipid metabolism balance may benefit patients with cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chao Liu, Zhongqin Wang, Kengquan Chen, Guanglin Cui, Chen Chen, Luyun Wang, Jiangang Jiang
Summary: In patients with fulminant myocarditis, most survivors experienced a decline in hs-cTnI within 24 hours, while the absolute and relative changes in hs-cTnI within 24 and 48 hours were strong predictors of in-hospital mortality.
BMC CARDIOVASCULAR DISORDERS
(2021)
Review
Oncology
Jiabing Zhan, Chen Chen, Dao Wen Wang, Huaping Li
Summary: Cardiovascular diseases are the leading cause of death in individuals with diabetes, with diabetic cardiomyopathy as a major complication. Hyperglycemia triggers multiple pathways leading to pathological changes in the heart. Intensive glycemic control does not reduce hospitalization and mortality in heart failure patients with diabetes, indicating a persistent hyperglycemic stress known as the hyperglycemic memory phenomenon.
FRONTIERS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yan Zhuang, Jin Wang, Huihui Li, Yanghui Chen, Chen Chen, Dao Wen Wang
Summary: The study identified plasma Siglec-5 and CD163 as valuable novel biomarkers for the early diagnosis of fulminant myocarditis (FM).
Article
Biochemistry & Molecular Biology
Lei Yang, Chen Chen, Bingya Lv, Yi Gao, Guangping Li
Summary: The study revealed that EETs can prevent LPS-induced inflammation and cardiomyocyte apoptosis via A(2A)R activation, offering potential cardioprotective effects in treating LPS-induced septic cardiac dysfunction.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2021)
Article
Biochemistry & Molecular Biology
Xudong Zhang, Shuai Yuan, Huaping Li, Jiabing Zhan, Feng Wang, Jiahui Fan, Xiang Nie, Yan Wang, Zheng Wen, Yanghui Chen, Chen Chen, Dao Wen Wang
Summary: This study revealed that miR-320 functions differently in various cell types of the heart during the progression of heart failure, with overexpression in CMs exacerbating cardiac dysfunction, and in CFs alleviating cardiac fibrosis and hypertrophy. The effects of miR-320 were mediated through targeting different downstream signaling pathways in CMs and CFs, and could be influenced by upstream regulators such as Ago2 and cell-type-specific transcription factors.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Hengzhi Du, Yanru Zhao, Zhongwei Yin, Dao Wen Wang, Chen Chen
Summary: Glucose and lipids are essential nutrients for maintaining body's energy balance, with metabolic disorders like diabetes on the rise globally. miR-320 plays a role in glucose and lipid metabolism, and is involved in diabetes-induced cardiac damage by activating fatty acid metabolism genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biology
Jin Wang, Shenglan Yang, Xingfa Liu, Yemao Zhang, Lijian Ding, Xiong Wu, Mengying He, Guoran Ruan, Jinsheng Lai, Chen Chen
Summary: Exposure to ELF-EMF at 1 mT for 24 weeks did not affect hematologic and biochemical indexes in adult rats, and no morphological changes were observed in the liver and kidney.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2021)