Regulation of microRNA function in animals

Phase Transitions in the Assembly and Function of Human miRISC

(2018) Jessica Sheu-Gruttadauria et al.   CELL

A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain

(2018) Benjamin Kleaveland et al.   CELL

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA degradation by a conserved target RNA regulates animal behavior

(2018) Angelo Bitetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5′ end from the cellular pyrophosphatases, DOM3Z and DUSP11

(2018) Yalena Amador-Cañizares et al.   NUCLEIC ACIDS RESEARCH

MicroRNA degradation by a conserved target RNA regulates animal behavior

(2018) Angelo Bitetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterizing isomiR variants within the microRNA-34/449 family

(2017) Olivier Mercey et al.   FEBS LETTERS

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

(2017) Yumeng Wang et al.   GENOME RESEARCH

A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

(2017) Masataka Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Foundations of RNA Silencing by Argonaute

(2017) Jessica Sheu-Gruttadauria et al.   JOURNAL OF MOLECULAR BIOLOGY

Comprehensive Identification of Nuclear and Cytoplasmic TNRC6A-Associating Proteins

(2017) Masataka Suzawa et al.   JOURNAL OF MOLECULAR BIOLOGY

Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates

(2017) Baekgyu Kim et al.   MOLECULAR CELL

Multivalent Recruitment of Human Argonaute by GW182

(2017) Elad Elkayam et al.   MOLECULAR CELL

A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis

(2017) Carlos Gorbea et al.   NATURE

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

(2017) Ryan J. Golden et al.   NATURE

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AUF1 facilitates microRNA-mediated gene silencing

(2017) Kyung-Won Min et al.   NUCLEIC ACIDS RESEARCH

A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing

(2017) Mathieu N. Flamand et al.   NUCLEIC ACIDS RESEARCH

Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types

(2017) Aristeidis G. Telonis et al.   NUCLEIC ACIDS RESEARCH

Naturally existing isoforms of miR-222 have distinct functions

(2017) Feng Yu et al.   NUCLEIC ACIDS RESEARCH

Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy

(2017) Zihui Zheng et al.   PLANT PHYSIOLOGY

3′ Uridylation controls mature microRNA turnover during CD4 T-cell activation

(2017) Cristina Gutiérrez-Vázquez et al.   RNA

Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition

(2017) Reyad A. Elbarbary et al.   SCIENCE

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

(2017) Monika Piwecka et al.   SCIENCE

Resolving Subcellular miRNA Trafficking and Turnover at Single-Molecule Resolution

(2017) Sethuramasundaram Pitchiaya et al.   Cell Reports

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

(2017) Katherine S. Bridge et al.   Cell Reports

Structure of Human DROSHA

(2016) S. Chul Kwon et al.   CELL

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration

(2016) Troels K.H. Scheel et al.   Cell Host & Microbe

Circular RNAs: analysis, expression and potential functions

(2016) Steven P. Barrett et al.   DEVELOPMENT

miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

(2016) Duygu Kuzuoğlu‐Öztürk et al.   EMBO JOURNAL

Degradation dynamics of microRNAs revealed by a novel pulse-chase approach

(2016) Matteo J. Marzi et al.   GENOME RESEARCH

Hepatitis B virus-human chimeric transcript HBx-LINE1 promotes hepatic injury via sequestering cellular microRNA-122

(2016) Hong-Wei Liang et al.   JOURNAL OF HEPATOLOGY

Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

(2016) Rémy Denzler et al.   MOLECULAR CELL

Pairing beyond the Seed Supports MicroRNA Targeting Specificity

(2016) James P. Broughton et al.   MOLECULAR CELL

General rules for functional microRNA targeting

(2016) Doyeon Kim et al.   NATURE GENETICS

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

A network-biology perspective of microRNA function and dysfunction in cancer

(2016) Cameron P. Bracken et al.   NATURE REVIEWS GENETICS

Large-scale analysis of microRNA expression, epi-transcriptomic features and biogenesis

(2016) Dimitrios M. Vitsios et al.   NUCLEIC ACIDS RESEARCH

High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs

(2016) Marianthi Karali et al.   NUCLEIC ACIDS RESEARCH

microRNA editing in seed region aligns with cellular changes in hypoxic conditions

(2016) Giovanni Nigita et al.   NUCLEIC ACIDS RESEARCH

Identification of factors involved in target RNA-directed microRNA degradation

(2016) Gabrielle Haas et al.   NUCLEIC ACIDS RESEARCH

Re-evaluation of the roles ofDROSHA,Exportin 5, andDICERin microRNA biogenesis

(2016) Young-Kook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress

(2016) Deepika Ahuja et al.   RNA Biology

Gld2-catalyzed 3′ monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior

(2016) Fernanda Mansur et al.   RNA

The APOBEC Protein Family: United by Structure, Divergent in Function

(2016) Jason D. Salter et al.   TRENDS IN BIOCHEMICAL SCIENCES

miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage

(2016) David W. Salzman et al.   Nature Communications

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes

(2016) Alireza Ahadi et al.   Scientific Reports

SUMOylation of Argonaute-2 regulates RNA interference activity

(2015) Fernando Josa-Prado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo

(2015) Florian A. Karreth et al.   CELL

Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides

(2015) William E. Salomon et al.   CELL

A Dynamic Search Process Underlies MicroRNA Targeting

(2015) Stanley D. Chandradoss et al.   CELL

Functional Anatomy of the Human Microprocessor

(2015) Tuan Anh Nguyen et al.   CELL

Hepatitis C Virus RNA Functionally Sequesters miR-122

(2015) Joseph M. Luna et al.   CELL

Potent degradation of neuronal miRNAs induced by highly complementary targets

(2015) M. de la Mata et al.   EMBO REPORTS

miR-122 – A key factor and therapeutic target in liver disease

(2015) Simonetta Bandiera et al.   JOURNAL OF HEPATOLOGY

Hepatitis C

(2015) Daniel P Webster et al.   LANCET

Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis

(2015) Ross C. Wilson et al.   MOLECULAR CELL

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Swiss army knives: non-canonical functions of nuclear Drosha and Dicer

(2015) Kaspar Burger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The expanding world of small RNAs in plants

(2015) Filipe Borges et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of the mammalian miRNA turnover landscape

(2015) Yanwen Guo et al.   NUCLEIC ACIDS RESEARCH

Altered expression and editing of miRNA-100 regulates iTreg differentiation

(2015) Vinny Negi et al.   NUCLEIC ACIDS RESEARCH

Destabilization of microRNAs in human cells by 3′ deadenylation mediated by PARN and CUGBP1

(2015) Takayuki Katoh et al.   NUCLEIC ACIDS RESEARCH

Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity

(2015) Aristeidis G. Telonis et al.   NUCLEIC ACIDS RESEARCH

RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4

(2015) D K Poria et al.   ONCOGENE

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA

(2015) Gaspare La Rocca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional analyses of phosphorylation events in human Argonaute 2

(2015) Joaquin Lopez-Orozco et al.   RNA

Divergent target recognition by coexpressed 5′-isomiRs of miR-142-3p and selective viral mimicry

(2015) Mark Manzano et al.   RNA

The Whereabouts of microRNA Actions: Cytoplasm and Beyond

(2015) Anthony K.L. Leung   TRENDS IN CELL BIOLOGY

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets

(2015) Nicole T Schirle et al.   eLife

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma

(2015) Sara Tomaselli et al.   GENOME BIOLOGY

Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression

(2014) Chi-Chiu Lau et al.   CANCER CELL

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Hepatitis C Virus Subverts Liver-Specific miR-122 to Protect the Viral Genome from Exoribonuclease Xrn2

(2014) Cecilia D. Sedano et al.   Cell Host & Microbe

Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting

(2014) Jin-Wu Nam et al.   MOLECULAR CELL

Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence

(2014) Ming Yang et al.   MOLECULAR CELL

Unambiguous Identification of miRNA:Target Site Interactions by Different Types of Ligation Reactions

(2014) Stefanie Grosswendt et al.   MOLECULAR CELL

A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer

(2014) Yuan Tian et al.   MOLECULAR CELL

MicroRNAs Block Assembly of eIF4F Translation Initiation Complex in Drosophila

(2014) Takashi Fukaya et al.   MOLECULAR CELL

MicroRNAs Trigger Dissociation of eIF4AI and eIF4AII from Target mRNAs in Humans

(2014) Akira Fukao et al.   MOLECULAR CELL

Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance

(2014) Rémy Denzler et al.   MOLECULAR CELL

Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition

(2014) Andrew D. Bosson et al.   MOLECULAR CELL

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

(2014) Stephen W. Eichhorn et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Clinical relevance of circulating cell-free microRNAs in cancer

(2014) Heidi Schwarzenbach et al.   Nature Reviews Clinical Oncology

Competition between target sites of regulators shapes post-transcriptional gene regulation

(2014) Marvin Jens et al.   NATURE REVIEWS GENETICS

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The evolutionary journey of Argonaute proteins

(2014) Daan C Swarts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

5′ isomiR variation is of functional and evolutionary importance

(2014) Geok Chin Tan et al.   NUCLEIC ACIDS RESEARCH

ADAR2 induces reproducible changes in sequence and abundance of mature microRNAs in the mouse brain

(2014) Cornelia Vesely et al.   NUCLEIC ACIDS RESEARCH

ADAR mediates differential expression of polycistronic microRNAs

(2014) Geetanjali Chawla et al.   NUCLEIC ACIDS RESEARCH

miRDB: an online resource for microRNA target prediction and functional annotations

(2014) Nathan Wong et al.   NUCLEIC ACIDS RESEARCH

TRIM65 regulates microRNA activity by ubiquitination of TNRC6

(2014) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease

(2014) J. Boele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for microRNA targeting

(2014) N. T. Schirle et al.   SCIENCE

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

(2014) Danijela Koppers-Lalic et al.   Cell Reports

Deletion of Human tarbp2 Reveals Cellular MicroRNA Targets and Cell-Cycle Function of TRBP

(2014) Yoosik Kim et al.   Cell Reports

Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding

(2013) Aleksandra Helwak et al.   CELL

Selective Degradation of Host MicroRNAs by an Intergenic HCMV Noncoding RNA Accelerates Virus Production

(2013) Sanghyun Lee et al.   Cell Host & Microbe

Reciprocal Inhibition between Intracellular Antiviral Signaling and the RNAi Machinery in Mammalian Cells

(2013) Gil Ju Seo et al.   Cell Host & Microbe

A transient reversal of miRNA-mediated repression controls macrophage activation

(2013) Anup Mazumder et al.   EMBO REPORTS

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire

(2013) Yelena Bronevetsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly Complementary Target RNAs Promote Release of Guide RNAs from Human Argonaute2

(2013) Nabanita De et al.   MOLECULAR CELL

Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets

(2013) Shane R. Horman et al.   MOLECULAR CELL

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Homeostatic control of Argonaute stability by microRNA availability

(2013) Peter Smibert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

(2013) Ho Young Lee et al.   NUCLEIC ACIDS RESEARCH

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs

(2013) K. Rogers et al.   PLANT CELL

Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate

(2013) K.-L. Huang et al.   RNA

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Ribonuclease III mechanisms of double-stranded RNA cleavage

(2013) Allen W. Nicholson   Wiley Interdisciplinary Reviews-RNA

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

(2012) Ryuya Fukunaga et al.   CELL

Quantitative functions of Argonaute proteins in mammalian development

(2012) D. Wang et al.   GENES & DEVELOPMENT

Evolution of Animal and Plant Dicers: Early Parallel Duplications and Recurrent Adaptation of Antiviral RNA Binding in Plants

(2012) Krishanu Mukherjee et al.   MOLECULAR BIOLOGY AND EVOLUTION

Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer

(2012) Stefan Uhlmann et al.   Molecular Systems Biology

Structure of yeast Argonaute with guide RNA

(2012) Kotaro Nakanishi et al.   NATURE

Autoregulation of microRNA biogenesis by let-7 and Argonaute

(2012) Dimitrios G. Zisoulis et al.   NATURE

The molecular architecture of human Dicer

(2012) Pick-Wei Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5′ exonucleolytic degradation

(2012) Joerg E Braun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

microRNAs associated with the different human Argonaute proteins

(2012) A. Dueck et al.   NUCLEIC ACIDS RESEARCH

Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex

(2012) T. Shimakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm

(2012) Anthony K.L. Leung et al.   RNA Biology

TRBP alters human precursor microRNA processing in vitro

(2012) H. Y. Lee et al.   RNA

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

MicroRNA turnover: when, how, and why

(2012) Stefan Rüegger et al.   TRENDS IN BIOCHEMICAL SCIENCES

IsomiRs – the overlooked repertoire in the dynamic microRNAome

(2012) Corine T. Neilsen et al.   TRENDS IN GENETICS

Specific miRNA Stabilization by Gld2-Catalyzed Monoadenylation

(2012) Andrea D’Ambrogio et al.   Cell Reports

An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma

(2011) Pavel Sumazin et al.   CELL

Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs

(2011) Yvonne Tay et al.   CELL

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

(2011) Florian A. Karreth et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity

(2011) S. K. Wyman et al.   GENOME RESEARCH

MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes

(2011) Olivia S. Rissland et al.   MOLECULAR CELL

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation

(2011) David M. Burns et al.   NATURE

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

(2011) Jong-Eun Park et al.   NATURE

Evolution of microRNA diversity and regulation in animals

(2011) Eugene Berezikov   NATURE REVIEWS GENETICS

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Non-coding RNAs as regulators of embryogenesis

(2011) Andrea Pauli et al.   NATURE REVIEWS GENETICS

Recognition of the pre-miRNA structure by Drosophila Dicer-1

(2011) Akihisa Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2011) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target

(2011) V. Libri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin

(2011) Alexander Maxwell Burroughs et al.   RNA Biology

Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing

(2011) J. A. Broderick et al.   RNA

MicroRNAs and their isomiRs function cooperatively to target common biological pathways

(2011) Nicole Cloonan et al.   GENOME BIOLOGY

Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs

(2010) Jacek Krol et al.   CELL

Canonical and alternate functions of the microRNA biogenesis machinery

(2010) M. M. W. Chong et al.   GENES & DEVELOPMENT

A comprehensive survey of 3' animal miRNA modification events and a possible role for 3' adenylation in modulating miRNA targeting effectiveness

(2010) A. M. Burroughs et al.   GENOME RESEARCH

Diverse Endonucleolytic Cleavage Sites in the Mammalian Transcriptome Depend upon MicroRNAs, Drosha, and Additional Nucleases

(2010) Fedor V. Karginov et al.   MOLECULAR CELL

The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

(2010) Pieter Mestdagh et al.   MOLECULAR CELL

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

(2010) Sihem Cheloufi et al.   NATURE

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

(2010) Martijn Kedde et al.   NATURE CELL BIOLOGY

Phosphorylation of human Argonaute proteins affects small RNA binding

(2010) Sabine Rüdel et al.   NUCLEIC ACIDS RESEARCH

Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection

(2010) A. H. Buck et al.   RNA

Dynamic isomiR regulation in Drosophila development

(2010) S. L. Fernandez-Valverde et al.   RNA

Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA

(2010) D. Cazalla et al.   SCIENCE

Target RNA-Directed Trimming and Tailing of Small Silencing RNAs

(2010) S. L. Ameres et al.   SCIENCE

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

(2010) D. Cifuentes et al.   SCIENCE

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

(2010) Doron Betel et al.   GENOME BIOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2

(2009) T. Katoh et al.   GENES & DEVELOPMENT

Zcchc11-dependent uridylation of microRNA directs cytokine expression

(2009) Matthew R. Jones et al.   NATURE CELL BIOLOGY

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

(2009) Chyi-Ying A Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

(2009) C. Okada et al.   SCIENCE

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

(2008) Yan Zeng et al.   BIOCHEMICAL JOURNAL

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

(2008) Catherine L. Jopling et al.   Cell Host & Microbe

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells

(2008) R. D. Morin et al.   GENOME RESEARCH

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Prolyl 4-hydroxylation regulates Argonaute 2 stability

(2008) Hank H. Qi et al.   NATURE

Structure of the guide-strand-containing argonaute silencing complex

(2008) Yanli Wang et al.   NATURE

Frequency and fate of microRNA editing in human brain

(2008) Y. Kawahara et al.   NUCLEIC ACIDS RESEARCH

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA