Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates

Vorinostat in autophagic cell death: A critical insight into autophagy-mediated, -associated and -dependent cell death for cancer prevention

(2021) Srimanta Patra et al.   DRUG DISCOVERY TODAY

Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets

(2021) Nasreddine El Omari et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Health beneficial and pharmacological properties of p-cymene

(2021) Abdelaali Balahbib et al.   FOOD AND CHEMICAL TOXICOLOGY

Health Benefits and Pharmacological Properties of Hinokitiol

(2021) Naoufal El Hachlafi et al.   Processes

Sources, health benefits, and biological properties of zeaxanthin

(2021) Abdelhakim Bouyahya et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates

(2021) Nasreddine El Omari et al.   Nutrients

Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells

(2021) Abdelhakim Bouyahya et al.   Antioxidants

Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms

(2021) Nasreddine El Omari et al.   Separations

SAHA and EGCG Promote Apoptosis in Triple-negative Breast Cancer Cells, Possibly Through the Modulation of cIAP2

(2020) KAYLA L. STEED et al.   ANTICANCER RESEARCH

Molecular mechanisms underlying eicosapentaenoic acid inhibition of HDAC1 and DNMT expression and activity in carcinoma cells

(2020) Veronica Ceccarelli et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Downregulation of serum exosomal miR‐320d predicts poor prognosis in hepatocellular carcinoma

(2020) Wenxiao Li et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

LY6K Promotes Glioblastoma Tumorigenicity via CAV-1-Mediated ERK1/2 Signaling Enhancement

(2020) Namratha G Sastry et al.   NEURO-ONCOLOGY

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically

(2020) Zhibin Yu et al.   ONCOGENE

SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms

(2020) Jing He et al.   ONCOGENE

RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice

(2020) Antje M. Richter et al.   ONCOGENE

Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells

(2020) Oskar Ciesielski et al.   MOLECULES

Therapeutic Effects of Curcumol in Several Diseases; An Overview

(2020) Sheema Hashem et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC

(2020) Xiaomei Liu et al.   Frontiers in Oncology

Regulation of DNA methylation machinery by epi-miRNAs in human cancer: emerging new targets in cancer therapy

(2020) Mohammad Reza Karimzadeh et al.   CANCER GENE THERAPY

HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation

(2020) Koji Nishimoto et al.   MOLECULAR CANCER RESEARCH

Exosomal miR-638 Inhibits Hepatocellular Carcinoma Progression by Targeting SP1

(2020) Jing Yang et al.   OncoTargets and Therapy

Elevated microRNA-7 inhibits proliferation and tumor angiogenesis and promotes apoptosis of gastric cancer cells via repression of Raf-1

(2020) Jing Lin et al.   CELL CYCLE

Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment

(2020) Xiaopeng Peng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparation of the phytotoxicity between chemically and green synthesized silver nanoparticles

(2020) Huiling Zhang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase

(2019) Ming-Jen Lee et al.   PHYTOMEDICINE

Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives

(2019) Danielle Q Calcagno et al.   Epigenomics

Identifying CYR 61 as a Potential Anti‐fibrotic and Pro‐angiogenic Mediator in Scleroderma

(2019) Pei‐Suen Tsou et al.   Arthritis & Rheumatology

Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer

(2019) Helai P. Mohammad et al.   NATURE MEDICINE

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

Green tea-induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase-3 suppresses prostate cancer progression through histone-modifying enzymes

(2019) Gauri Deb et al.   MOLECULAR CARCINOGENESIS

Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling

(2019) Jian Guo et al.   CIRCULATION RESEARCH

Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway

(2019) Hsiao-Chen Dina Kuo et al.   AAPS Journal

Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy

(2019) Srimanta Patra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells

(2019) Madhumitha Kedhari Sundaram et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding

(2019) Joshua J. Gruber et al.   MOLECULAR CELL

Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma

(2019) Giada Juli et al.   Cancers

Pelargonidin reduces the TPA induced transformation of mouse epidermal cells –potential involvement of Nrf2 promoter demethylation

(2019) Shanyi Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Current role of mammalian sirtuins in DNA repair

(2019) Francisco Alejandro Lagunas-Rangel   DNA REPAIR

Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms

(2019) Eduardo Izquierdo-Torres et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1

(2019) Riya Gupta et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress

(2019) Richa Garva et al.   Frontiers in Oncology

RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial–mesenchymal transition and promotes metastasis of colorectal cancer

(2019) Chao Xiao et al.   Cell Death & Disease

Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

(2019) Patrick L. Leslie et al.   Nature Communications

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

(2019) Priscillia Lhoumaud et al.   Nature Communications

Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells

(2019) Patrick Wellington da Silva dos Santos et al.   FOOD AND CHEMICAL TOXICOLOGY

microRNA-181 serves as a dual-role regulator in the development of human cancers

(2019) Tayebeh Rezaei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genistein Induces Alterations of Epigenetic Modulatory Signatures in Human Cervical Cancer Cells

(2018) Madhumitha Kedhari Sundaram et al.   Anti-Cancer Agents in Medicinal Chemistry

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines

(2018) Fiona R. Kolbinger et al.   ARCHIVES OF TOXICOLOGY

Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms

(2018) Yuanyuan Li et al.   Cancer Prevention Research

The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation

(2018) Bidisha Paul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemical Compositions of Walnut (Juglans regia L.) Oils from Different Cultivated Regions in China

(2018) Pan Gao et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

Correction: Role of novel histone modifications in cancer

(2018) Muthu K. Shanmugam et al.   Oncotarget

Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression

(2018) Xiao Chen et al.   Theranostics

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

(2018) Dong Fang et al.   eLife

Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation

(2018) Zheng Peng et al.   MEDICAL SCIENCE MONITOR

Combinational Proanthocyanidins and Resveratrol Synergistically Inhibit Human Breast Cancer Cells and Impact Epigenetic–Mediating Machinery

(2018) Yifeng Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells

(2018) Qian Zuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Synergistic activity of imatinib and AR-42 against chronic myeloid leukemia cells mainly through HDAC1 inhibition

(2018) Danna Wei et al.   LIFE SCIENCES

Depsidone Derivatives and a Cyclopeptide Produced by Marine Fungus Aspergillus unguis under Chemical Induction and by Its Plasma Induced Mutant

(2018) Wen-Cong Yang et al.   MOLECULES

HDAC inhibition improves autophagic and lysosomal function to prevent loss of subcutaneous fat in a mouse model of Cockayne syndrome

(2018) Marc Majora et al.   Science Translational Medicine

HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27

(2018) Carrie Draney et al.   BIOCHEMICAL JOURNAL

Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

(2018) Jon D. Larson et al.   CANCER CELL

SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer

(2018) Liang Shi et al.   Molecular Oncology

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resveratrol: A miraculous natural compound for diseases treatment

(2018) Mehdi Koushki et al.   Food Science & Nutrition

Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism

(2017) Igor Hrgovic et al.   EXPERIMENTAL DERMATOLOGY

Exploring the epigenetic drug discovery landscape

(2017) Veda Prachayasittikul et al.   Expert Opinion on Drug Discovery

Taxifolin Activates the Nrf2 Anti-Oxidative Stress Pathway in Mouse Skin Epidermal JB6 P+ Cells through Epigenetic Modifications

(2017) Haixue Kuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

(2017) Kendra Royston et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells

(2017) Veronika Borutinskaitė et al.   LEUKEMIA & LYMPHOMA

Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes

(2017) Chengyue Zhang et al.   MOLECULAR PHARMACEUTICS

Marked for death: targeting epigenetic changes in cancer

(2017) Sophia Xiao Pfister et al.   NATURE REVIEWS DRUG DISCOVERY

Z-ligustilide restores tamoxifen sensitivity of ERα negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERα

(2017) Hui Ma et al.   Oncotarget

MiR-29b/TET1/ZEB2 signaling axis regulates metastatic properties and epithelial-mesenchymal transition in breast cancer cells

(2017) Hua Wang et al.   Oncotarget

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

(2017) Jung Eun Park et al.   Scientific Reports

Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity

(2016) Li-Li Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth

(2016) R. Pathania et al.   CANCER RESEARCH

Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1expression

(2016) Tsui-Hwa Tseng et al.   ENVIRONMENTAL TOXICOLOGY

Dysregulation of TET2 in hematologic malignancies

(2016) Shigeru Chiba   INTERNATIONAL JOURNAL OF HEMATOLOGY

Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc

(2016) Zachary R Schoepflin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells

(2016) Hyuck Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells

(2016) Yue Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma

(2016) Ioannis Anestopoulos et al.   MOLECULES

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition

(2016) Siming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

(2016) D. Fang et al.   SCIENCE

Berberine acts as a putative epigenetic modulator by affecting the histone code

(2016) Zhixiang Wang et al.   TOXICOLOGY IN VITRO

Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition

(2016) Tao Zhang et al.   Cell Death & Disease

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

(2016) Cristina Florean et al.   Oncotarget

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

(2016) Michael Van Meter et al.   Cell Reports

SIRT5 regulation of ammonia-induced autophagy and mitophagy

(2015) Lucia Polletta et al.   Autophagy

Green tea polyphenol EGCG reverse cisplatin resistance of A549/DDP cell line through candidate genes demethylation

(2015) Youwei Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer

(2015) Rishabh Kala et al.   BMC CANCER

Ten things you should know about protein kinases: IUPHAR Review 14

(2015) Doriano Fabbro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis

(2015) S. Shukla et al.   Cancer Prevention Research

AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol

(2015) Shuyang Chen et al.   CELL CYCLE

Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1

(2015) Gaurav Parashar et al.   CLINICAL AND EXPERIMENTAL MEDICINE

FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma

(2015) H.-Z. Lee et al.   CLINICAL CANCER RESEARCH

Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells

(2015) MIN YOUNG KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Synergistic Effect of SAHA and Parthenolide in MDA-MB231 Breast Cancer Cells

(2015) Daniela Carlisi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells

(2015) H. Zeng et al.   NEUROSCIENCE

(−)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells

(2015) MUNAWWAR ALI KHAN et al.   ONCOLOGY REPORTS

Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells

(2015) Da Liu et al.   PLoS One

Downregulation of miR-329 promotes cell invasion by regulating BRD4 and predicts poor prognosis in hepatocellular carcinoma

(2015) Jianping Zhou et al.   TUMOR BIOLOGY

Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway

(2014) Ling Wang et al.   AAPS Journal

Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications

(2014) Ximena Paredes-Gonzalez et al.   AAPS Journal

Aberrant Epigenetic Alteration in Eca9706 Cells Modulated by Nanoliposomal Quercetin Combined with Butyrate Mediated via Epigenetic-NF-κB Signaling

(2014) Nai-Gang Zheng et al.   Asian Pacific Journal of Cancer Prevention

Overexpression of p300 correlates with poor prognosis in patients with cutaneous squamous cell carcinoma

(2014) M.-K. Chen et al.   BRITISH JOURNAL OF DERMATOLOGY

Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate

(2014) Sabita N. Saldanha et al.   EXPERIMENTAL CELL RESEARCH

Diet is a major factor governing the fecal butyrate-producing community structure across Mammalia, Aves and Reptilia

(2014) Marius Vital et al.   ISME Journal

Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification

(2014) Inhae Kang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells

(2014) Gauri Deb et al.   MOLECULAR CARCINOGENESIS

HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

(2014) Mu Zhang et al.   MOLECULAR CELL

HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels

(2014) Yindi Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress

(2014) Xuan Ou et al.   STEM CELLS

Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents

(2014) Prakash Tiwari et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development

(2013) Yukun Zhang et al.   CARCINOGENESIS

Phase I Study of Panobinostat plus Everolimus in Patients with Relapsed or Refractory Lymphoma

(2013) Y. Oki et al.   CLINICAL CANCER RESEARCH

Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3

(2013) FANLIANG MENG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins

(2013) Sameer Mirza et al.   Journal of Breast Cancer

Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma

(2013) Ping Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

(2013) Yuanyuan Li et al.   Molecular Cancer

Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric

(2013) Bharat B. Aggarwal et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Histone deacetylase 10 promotes autophagy-mediated cell survival

(2013) I. Oehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic effects of the natural flavonolignan silibinin on colon adenocarcinoma cells and their derived metastatic cells

(2013) HENRIETTE KAUNTZ et al.   Oncology Letters

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Inhibition of Tumor Promotion by Parthenolide: Epigenetic Modulation of p21

(2012) A. Ghantous et al.   Cancer Prevention Research

miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma

(2012) A. L. Kasinski et al.   CANCER RESEARCH

Aberrant DNA Methylation and Prostate Cancer

(2012) Sunipa Majumdar et al.   CURRENT GENOMICS

Cancer epigenomics: beyond genomics

(2012) Juan Sandoval et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Results From a Pivotal, Open-Label, Phase II Study of Romidepsin in Relapsed or Refractory Peripheral T-Cell Lymphoma After Prior Systemic Therapy

(2012) Bertrand Coiffier et al.   JOURNAL OF CLINICAL ONCOLOGY

Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets

(2012) Matthias G. J. Baud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases

(2012) Alexander Berger et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

(2012) Hacer Karatas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system

(2012) D.G. Machado et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells

(2012) S. Kubicek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice

(2012) V. Moresi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells

(2011) Limin Shu et al.   AAPS Journal

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

(2011) Seung Joon Lee et al.   BMC CANCER

CpG island methylation profiling in human salivary gland adenoid cystic carcinoma

(2011) Achim Bell et al.   CANCER

A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells

(2011) S. M. Meeran et al.   Cancer Prevention Research

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

(2011) V. Nandakumar et al.   CARCINOGENESIS

Aberrations of EZH2 in Cancer

(2011) A. Chase et al.   CLINICAL CANCER RESEARCH

Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin

(2011) David Kaluza et al.   EMBO JOURNAL

Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells

(2011) Miwako Kondo et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study

(2011) Mitali Pandey et al.   MOLECULAR CARCINOGENESIS

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE

The Flavonoid Quercetin Modulates the Hallmark Capabilities of Hamster Buccal Pouch Tumors

(2011) Ramamurthi Vidya Priyadarsini et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer

(2011) ShanShan He et al.   PLoS One

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1α to reverse HRE site in the promoter

(2010) Kyung Ju Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Arsenic trioxide — An old drug rediscovered

(2010) Ashkan Emadi et al.   BLOOD REVIEWS

The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells

(2010) Yun Dai et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells

(2010) Samir Attoub et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigenetics and cancer

(2010) Rajnee Kanwal et al.   JOURNAL OF APPLIED PHYSIOLOGY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone deacetylases and epigenetic therapies of hematological malignancies

(2010) Ciro Mercurio et al.   PHARMACOLOGICAL RESEARCH

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

(2010) Syed M. Meeran et al.   PLoS One

Hypomethylation of repeated DNA sequences in cancer

(2010) Jason P Ross et al.   Epigenomics

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies

(2009) Gamze Bora-Tatar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells

(2009) C. Urbich et al.   BLOOD

Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer

(2009) Shahana Majid et al.   CANCER

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

(2009) J. M. Friedman et al.   CANCER RESEARCH

The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

(2009) T. Liu et al.   CANCER RESEARCH

Histone Deacetylase Inhibitors

(2009) Xujun Ma et al.   DRUGS

Epigenetics and cancer treatment

(2009) Lasse Sommer Kristensen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

(2009) Johannes von Burstin et al.   GASTROENTEROLOGY

Epigenetic regulation of microRNA expression in colorectal cancer

(2009) Eva Bandres et al.   INTERNATIONAL JOURNAL OF CANCER

Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators

(2009) Samiha Mateen et al.   MOLECULAR CARCINOGENESIS

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors

(2008) Jung-Hyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes

(2008) M. Inomata et al.   BLOOD

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

(2008) Y.-S. Lee et al.   CANCER RESEARCH

Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo

(2008) W. Weichert et al.   CLINICAL CANCER RESEARCH

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

(2008) I. Oehme et al.   CLINICAL CANCER RESEARCH

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

(2008) Francesco Cecconi et al.   DEVELOPMENTAL CELL

Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases

(2008) Audrey Vincent et al.   FASEB JOURNAL

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

(2008) Srividya Bhaskara et al.   MOLECULAR CELL

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

(2008) D Mottet et al.   ONCOGENE

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE

A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells

(2007) Mee Young Ahn et al.   GYNECOLOGIC ONCOLOGY