Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide

(2011) J Chang et al.   BRITISH JOURNAL OF CANCER

Epigenetics in Alternative Pre-mRNA Splicing

(2011) Reini F. Luco et al.   CELL

How epigenetics can explain human metastasis: A new role for microRNAs

(2011) Amaia Lujambio et al.   CELL CYCLE

SRSF2 is required for sodium butyrate-mediated p21WAF1 induction and premature senescence in human lung carcinoma cell lines

(2011) Valerie Edmond et al.   CELL CYCLE

Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis

(2011) Jennifer Jurkin et al.   CELL CYCLE

MicroRNAs and epigenetics

(2011) Fumiaki Sato et al.   FEBS Journal

The central role of RNA in human development and cognition

(2011) John S. Mattick   FEBS LETTERS

SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing

(2011) Y. Chen et al.   GENES & DEVELOPMENT

HDAC6 α-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases

(2011) Guoyi Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly

(2011) Praveen Rajendran et al.   Molecular Cancer

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Histone Deacetylase Activity Modulates Alternative Splicing

(2011) Jarmila Hnilicová et al.   PLoS One

Quantitative Proteomics Identify Novel miR-155 Target Proteins

(2011) Christopher Lößner et al.   PLoS One

Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner

(2011) H.-L. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic histone acetylation is critical for cotranscriptional spliceosome assembly and spliceosomal rearrangements

(2011) Felizza Q. Gunderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease

(2010) K.F. Chung et al.   Annals of the New York Academy of Sciences

Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

(2010) Srividya Bhaskara et al.   CANCER CELL

Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs

(2010) Susana Gonzalez et al.   CELL CYCLE

Deacetylase Inhibitors Dissociate the Histone-Targeting ING2 Subunit from the Sin3 Complex

(2010) Karen T. Smith et al.   CHEMISTRY & BIOLOGY

Regulatory signal transduction pathways for class IIa histone deacetylases

(2010) Maribel Parra et al.   CURRENT OPINION IN PHARMACOLOGY

Chromatin: The Final Frontier in Splicing Regulation?

(2010) Kristi Fox-Walsh et al.   DEVELOPMENTAL CELL

Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

(2010) Sabine Lagger et al.   EMBO JOURNAL

Inside HDAC with HDAC inhibitors

(2010) Philippe Bertrand   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HDACi - going through the mechanisms

(2010) Malgorzata Wanczyk   Frontiers in Bioscience-Landmark

Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression

(2010) T. Yamaguchi et al.   GENES & DEVELOPMENT

A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors

(2010) Elisabeth Simboeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mammalian Complex Containing Sin3B Mitigates Histone Acetylation and RNA Polymerase II Progression within Transcribed Loci

(2010) P. Jelinic et al.   MOLECULAR AND CELLULAR BIOLOGY

Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans

(2010) Ryan J Taft et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex

(2010) Bojan Drobic et al.   NUCLEIC ACIDS RESEARCH

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

(2010) Julia M. Wagner et al.   Clinical Epigenetics

Histone deacetylases: salesmen and customers in the post-translational modification market

(2009) André Brandl et al.   BIOLOGY OF THE CELL

Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation

(2009) Xiaoqing Li et al.   BRITISH JOURNAL OF HAEMATOLOGY

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Inhibition of Histone Deacetylases: A Pharmacological Approach to the Treatment of Non-Cancer Disorders

(2009) Norbert Wiech et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Transcriptional Regulation by Promoter Targeted RNAs

(2009) Kazuo Suzuki et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Epigenetic regulation of microRNA expression in colorectal cancer

(2009) Eva Bandres et al.   INTERNATIONAL JOURNAL OF CANCER

Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation

(2009) Reinhard Brunmeir et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Class IIa histone deacetylases: conducting development and differentiation

(2009) Maud Martin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Trans-regulation of Histone Deacetylase Activities through Acetylation

(2009) Yi Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

(2009) E J Noonan et al.   ONCOGENE

Histone deacetylases and the immunological network: implications in cancer and inflammation

(2009) A Villagra et al.   ONCOGENE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Role of HDAC2 in the Pathophysiology of COPD

(2008) Peter J. Barnes   Annual Review of Physiology

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis

(2008) J. Datta et al.   CANCER RESEARCH

Eloquent silence: developmental functions of Class I histone deacetylases

(2008) Vincent T Cunliffe   CURRENT OPINION IN GENETICS & DEVELOPMENT

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development

(2008) Jessica L. MacDonald et al.   DEVELOPMENTAL DYNAMICS

Histone deacetylase inhibitors: Anticancer compounds

(2008) Karen T. Smith et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Closed Chromatin Architecture Is Induced by an RNA Duplex Targeting the HIV-1 Promoter Region

(2008) Kazuo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

(2008) Xiang-Jiao Yang et al.   MOLECULAR CELL

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

(2008) Jiancong Liang et al.   NATURE CELL BIOLOGY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

(2008) Agustín Valenzuela-Fernández et al.   TRENDS IN CELL BIOLOGY