Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc

Prolyl-4-hydroxylase Domain Protein 2 Controls NF-κB/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus

(2015) Jun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

(2015) Makarand V. Risbud et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells

(2014) Yuichiro Hirose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP

(2014) Zariel I. Johnson et al.   MATRIX BIOLOGY

VPA inhibits renal cancer cell migration by targeting HDAC2 and down-regulating HIF-1α

(2014) Feng-qiang Yang et al.   MOLECULAR BIOLOGY REPORTS

The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition

(2014) Darren M. Hutt et al.   PLoS One

Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

(2014) Christophe Merceron et al.   PLoS One

HDAC6 Deacetylase Activity Is Required for Hypoxia-Induced Invadopodia Formation and Cell Invasion

(2013) Dominique Arsenault et al.   PLoS One

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Modulation of Histone Deacetylase 6 (HDAC6) Nuclear Import and Tubulin Deacetylase Activity through Acetylation

(2012) Yuanjing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: Role of Hsp70 in HIF-1α degradation

(2012) Shilpa S Gogate et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Is the spinal motion segment a diarthrodial polyaxial joint: What a nice nucleus like you doing in a joint like this?

(2011) Irving M. Shapiro et al.   BONE

HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia

(2011) Hao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc

(2011) Nobuyuki Fujita et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypoxic Regulation of Nucleus Pulposus Cell Survival

(2010) Makarand V. Risbud et al.   AMERICAN JOURNAL OF PATHOLOGY

Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity

(2009) Younho Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complex Regulation of the Transactivation Function of Hypoxia-inducible Factor-1α by Direct Interaction with Two Distinct Domains of the CREB-binding Protein/p300

(2009) Jorge L. Ruas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo

(2009) Y. A. Minamishima et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

(2009) B. Chen et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc

(2008) Amit Agrawal et al.   ARTHRITIS AND RHEUMATISM

Transcriptional activation of hypoxia-inducible factor-1α by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1

(2008) Hee-Won Seo et al.   FEBS LETTERS