Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies

(2015) A. L. Wong et al.   ANNALS OF ONCOLOGY

Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, by down-regulating EGFR expression

(2015) Jingjie Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Osteosarcoma: Current Treatment and a Collaborative Pathway to Success

(2015) Michael S. Isakoff et al.   JOURNAL OF CLINICAL ONCOLOGY

SHP-1 is a negative regulator of epithelial–mesenchymal transition in hepatocellular carcinoma

(2015) L-C Fan et al.   ONCOGENE

RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells

(2014) J.-C. Su et al.   CARCINOGENESIS

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

(2014) U Bharadwaj et al.   ONCOGENE

Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function

(2014) Jia Shen et al.   Cell Reports

Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer

(2014) Tao Zhang et al.   NEOPLASIA

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

(2013) Mi-Jung Kim et al.   CANCER LETTERS

Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

(2013) D. Siolas et al.   CANCER RESEARCH

EMT transcription factors: implication in osteosarcoma

(2013) Guoqiong Yang et al.   MEDICAL ONCOLOGY

Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion

(2012) Tao Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma

(2012) Bing Tu et al.   CANCER LETTERS

Roles of STAT3 and ZEB1 Proteins in E-cadherin Down-regulation and Human Colorectal Cancer Epithelial-Mesenchymal Transition

(2011) Hua Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1-Mediated Inhibition of STAT3

(2011) W.-T. Tai et al.   MOLECULAR CANCER THERAPEUTICS

Silencing of Autocrine Motility Factor Induces Mesenchymal-to-Epithelial Transition and Suppression of Osteosarcoma Pulmonary Metastasis

(2010) Y. Niinaka et al.   CANCER RESEARCH

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway

(2010) Y. Dong et al.   CARCINOGENESIS

Patient-Derived First Generation Xenografts of Non-Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy

(2010) X. Dong et al.   CLINICAL CANCER RESEARCH

Characterization of STAT3 activation and expression in canine and human osteosarcoma

(2009) Stacey L Fossey et al.   BMC CANCER

Osteosarcoma incidence and survival rates from 1973 to 2004

(2009) Lisa Mirabello et al.   CANCER

Establishment and characterization of a new highly metastatic human osteosarcoma cell line

(2009) Yuxi Su et al.   CLINICAL & EXPERIMENTAL METASTASIS

STAT3 as a Central Regulator of Tumor Metastases

(2009) Eswaran Devarajan et al.   CURRENT MOLECULAR MEDICINE

The Role of STAT-3 in the Induction of Apoptosis in Pancreatic Cancer Cells by Benzyl Isothiocyanate

(2009) R. P. Sahu et al.   JNCI-Journal of the National Cancer Institute

Anti-inflammatory Activity of Pectolinarigenin and Pectolinarin Isolated from Cirsium chanroenicum

(2008) Hyun Lim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines

(2008) Marco Bonesi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3

(2007) Rebecka Hellsten et al.   PROSTATE